Safety, pharmacokinetics and quantitative EEG modulation of TAK‐071, a novel muscarinic M1 receptor positive allosteric modulator, in healthy subjects

por Yin, Wei, Mamashli, Fahimeh, Buhl, Derek L., Khudyakov, Polyna, Volfson, Dmitri, Martenyi, Ferenc, Gevorkyan, Hakop, Rosen, Laura, Simen, Arthur A.
Publicado 2021

Central nervous system effects of TAK-653, an investigational alpha-amino-3-hydroxy-5-methyl-4-isoxazole receptor (AMPAR) positive allosteric modulator in healthy volunteers

por Dijkstra, Francis, O’Donnell, Patricio, Klaassen, Erica, Buhl, Derek, Asgharnejad, Mahnaz, Rosen, Laura, Zuiker, Rob, van Gerven, Joop, Jacobs, Gabriël
Publicado 2022

A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists

por Stroebel, David, Buhl, Derek L., Knafels, John D., Chanda, Pranab K., Green, Michael, Sciabola, Simone, Mony, Laetitia, Paoletti, Pierre, Pandit, Jayvardhan
Publicado 2016

Schizophrenia-associated SLC39A8 polymorphism is a loss-of-function allele altering glutamate receptor and innate immune signaling

por Tseng, Wei Chou, Reinhart, Veronica, Lanz, Thomas A., Weber, Mark L., Pang, Jincheng, Le, Kevin Xuong Vinh, Bell, Robert D., O’Donnell, Patricio, Buhl, Derek L.
Publicado 2021

Hyperactivity and Hypermotivation Associated With Increased Striatal mGluR1 Signaling in a Shank2 Rat Model of Autism

por Modi, Meera E., Brooks, Julie M., Guilmette, Edward R., Beyna, Mercedes, Graf, Radka, Reim, Dominik, Schmeisser, Michael J., Boeckers, Tobias M., O’Donnell, Patricio, Buhl, Derek L.
Publicado 2018

Peripheral Administration of a Long-Acting Peptide Oxytocin Receptor Agonist Inhibits Fear-Induced Freezing

por Modi, Meera E., Majchrzak, Mark J., Fonseca, Kari R., Doran, Angela, Osgood, Sarah, Vanase-Frawley, Michelle, Feyfant, Eric, McInnes, Heather, Darvari, Ramin, Buhl, Derek L., Kablaoui, Natasha M.
Publicado 2016

GluN2D-mediated excitatory drive onto medial prefrontal cortical PV+ fast-spiking inhibitory interneurons

por Garst-Orozco, Jonathan, Malik, Ruchi, Lanz, Thomas A., Weber, Mark L., Xi, Hualin, Arion, Dominique, Enwright, John F., Lewis, David A., O’Donnell, Patricio, Sohal, Vikaas S., Buhl, Derek L.
Publicado 2020

The D-amino acid oxidase inhibitor luvadaxistat improves mismatch negativity in patients with schizophrenia in a randomized trial

por O’Donnell, Patricio, Dong, Cheng, Murthy, Venkatesha, Asgharnejad, Mahnaz, Du, Xiaoming, Summerfelt, Ann, Lu, Hong, Xu, Lin, Wendland, Jens R., Dunayevich, Eduardo, Buhl, Derek L., Litman, Robert, Hetrick, William P., Hong, L. Elliot, Rosen, Laura B.
Publicado 2023

Reproducibility via coordinated standardization: a multi-center study in a Shank2 genetic rat model for Autism Spectrum Disorders

por Arroyo-Araujo, María, Graf, Radka, Maco, Martine, van Dam, Elsbeth, Schenker, Esther, Drinkenburg, Wilhelmus, Koopmans, Bastijn, de Boer, Sietse F., Cullum-Doyle, Michaela, Noldus, Lucas P. J. J., Loos, Maarten, van Dommelen, Wil, Spooren, Will, Biemans, Barbara, Buhl, Derek L., Kas, Martien J.
Publicado 2019

Transcranial magnetic stimulation as a translational biomarker for AMPA receptor modulation

por O’Donnell, Patricio, Dijkstra, Francis M., Damar, Ugur, Quanhong, Lei, de Goede, Annika A., Xu, Lin, Pascual-Leone, Andres, Buhl, Derek L., Zuiker, Rob, Ruijs, Titia Q., Heuberger, Jules A. A. C., MacMullin, Paul, Lubell, Martin, Asgharnejad, Mahnaz, Murthy, Venkatesha, Rotenberg, Alexander, Jacobs, Gabriel E., Rosen, Laura
Publicado 2021