Identification of deubiquitinase inhibitors via high-throughput screening using a fluorogenic ubiquitin-rhodamine assay

por Varca, Anthony C., Casalena, Dominick, Auld, Douglas, Buhrlage, Sara J.
Publicado 2021

Integrating multi-omics data reveals function and therapeutic potential of deubiquitinating enzymes

por Doherty, Laura M, Mills, Caitlin E, Boswell, Sarah A, Liu, Xiaoxi, Hoyt, Charles Tapley, Gyori, Benjamin, Buhrlage, Sara J, Sorger, Peter K
Publicado 2022

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases

por Banerjee, Sourav, Buhrlage, Sara J., Huang, Hai-Tsang, Deng, Xianming, Zhou, Wenjun, Wang, Jinhua, Traynor, Ryan, Prescott, Alan R., Alessi, Dario R., Gray, Nathanael S.
Publicado 2013

Repurposing of Kinase Inhibitors for Treatment of COVID-19

por Weisberg, Ellen, Parent, Alexander, Yang, Priscilla L., Sattler, Martin, Liu, Qingsong, Liu, Qingwang, Wang, Jinhua, Meng, Chengcheng, Buhrlage, Sara J., Gray, Nathanael, Griffin, James D.
Publicado 2020

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

por Ritorto, Maria Stella, Ewan, Richard, Perez-Oliva, Ana B., Knebel, Axel, Buhrlage, Sara J., Wightman, Melanie, Kelly, Sharon M., Wood, Nicola T., Virdee, Satpal, Gray, Nathanael S., Morrice, Nicholas A., Alessi, Dario R., Trost, Matthias
Publicado 2014

Effects of the multi‐kinase inhibitor midostaurin in combination with chemotherapy in models of acute myeloid leukaemia

por Weisberg, Ellen, Meng, Chengcheng, Case, Abigail E., Tiv, Hong L., Gokhale, Prafulla C., Buhrlage, Sara J., Yang, Jing, Liu, Xiaoxi, Wang, Jinhua, Gray, Nathanael, Adamia, Sophia, Sattler, Martin, Stone, Richard, Griffin, James D.
Publicado 2020

Akkermansia muciniphila phospholipid induces homeostatic immune responses

por Bae, Munhyung, Cassilly, Chelsi D., Liu, Xiaoxi, Park, Sung-Moo, Tusi, Betsabeh Khoramian, Chen, Xiangjun, Kwon, Jaeyoung, Filipčík, Pavel, Bolze, Andrew S., Liu, Zehua, Vlamakis, Hera, Graham, Daniel B., Buhrlage, Sara J., Xavier, Ramnik J., Clardy, Jon
Publicado 2022

Characterization of midostaurin as a dual inhibitor of FLT3 and SYK and potentiation of FLT3 inhibition against FLT3-ITD-driven leukemia harboring activated SYK kinase

por Weisberg, Ellen L., Puissant, Alexandre, Stone, Richard, Sattler, Martin, Buhrlage, Sara J., Yang, Jing, Manley, Paul W., Meng, Chengcheng, Buonopane, Michael, Daley, John F., Lazo, Suzan, Wright, Renee, Weinstock, David M., Christie, Amanda L., Stegmaier, Kimberly, Griffin, James D.
Publicado 2017

Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma

por Stolte, Björn, Iniguez, Amanda Balboni, Dharia, Neekesh V., Robichaud, Amanda L., Conway, Amy Saur, Morgan, Ann M., Alexe, Gabriela, Schauer, Nathan J., Liu, Xiaoxi, Bird, Gregory H., Tsherniak, Aviad, Vazquez, Francisca, Buhrlage, Sara J., Walensky, Loren D., Stegmaier, Kimberly
Publicado 2018

Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2)

por Tan, Li, Nomanbhoy, Tyzoon, Gurbani, Deepak, Patricelli, Matthew, Hunter, John, Geng, Jiefei, Herhaus, Lina, Zhang, Jianming, Pauls, Eduardo, Ham, Youngjin, Choi, Hwan Geun, Xie, Ting, Deng, Xianming, Buhrlage, Sara J., Sim, Taebo, Cohen, Philip, Sapkota, Gopal, Westover, Kenneth D., Gray, Nathanael S.
Publicado 2014

Inhibiting Fungal Multidrug Resistance by Disrupting an Activator-Mediator Interaction

por Nishikawa, Joy L., Boeszoermenyi, Andras, Vale-Silva, Luis A., Torelli, Riccardo, Posteraro, Brunella, Sohn, Yoo-Jin, Ji, Fei, Gelev, Vladimir, Sanglard, Dominique, Sanguinetti, Maurizio, Sadreyev, Ruslan I., Mukherjee, Goutam, Bhyravabhotla, Jayaram, Buhrlage, Sara J., Gray, Nathanael S., Wagner, Gerhard, Näär, Anders M., Arthanari, Haribabu
Publicado 2016

Accelerating inhibitor discovery for deubiquitinating enzymes

por Chan, Wai Cheung, Liu, Xiaoxi, Magin, Robert S., Girardi, Nicholas M., Ficarro, Scott B., Hu, Wanyi, Tarazona Guzman, Maria I., Starnbach, Cara A., Felix, Alejandra, Adelmant, Guillaume, Varca, Anthony C., Hu, Bin, Bratt, Ariana S., DaSilva, Ethan, Schauer, Nathan J., Jaen Maisonet, Isabella, Dolen, Emma K., Ayala, Anthony X., Marto, Jarrod A., Buhrlage, Sara J.
Publicado 2023

Discovery of a Potent, Covalent BTK Inhibitor for B-Cell Lymphoma

por Wu, Hong, Wang, Wenchao, Liu, Feiyang, Weisberg, Ellen L., Tian, Bei, Chen, Yongfei, Li, Binhua, Wang, Aoli, Wang, Beilei, Zhao, Zheng, McMillin, Douglas W., Hu, Chen, Li, Hong, Wang, Jinhua, Liang, Yanke, Buhrlage, Sara J., Liang, Junting, Liu, Jing, Yang, Guang, Brown, Jennifer R., Treon, Steven P., Mitsiades, Constantine S., Griffin, James D., Liu, Qingsong, Gray, Nathanael S.
Publicado 2014

SYK is activated by mutated MYD88 and drives pro-survival signaling in MYD88 driven B-cell lymphomas

por Munshi, Manit, Liu, Xia, Chen, Jiaji G., Xu, Lian, Tsakmaklis, Nickolas, Demos, Maria G., Kofides, Amanda, Guerrera, Maria Luisa, Jimenez, Cristina, Chan, Gloria G., Hunter, Zachary R., Palomba, M. Lia, Argyropoulos, Kimon V., Meid, Kirsten, Keezer, Andrew, Gustine, Joshua, Dubeau, Toni, Castillo, Jorge J., Patterson, Christopher J., Wang, Jinhua, Buhrlage, Sara J., Gray, Nathanael S., Treon, Steven P., Yang, Guang
Publicado 2020

A new role for the SRC family kinase HCK as a driver of SYK activation in MYD88 mutated lymphomas

por Munshi, Manit, Liu, Xia, Kofides, Amanda, Tsakmaklis, Nickolas, Guerrera, Maria Luisa, Hunter, Zachary R., Palomba, M. Lia, Argyropoulos, Kimon V., Patterson, Christopher J., Canning, Alexa G., Meid, Kirsten, Gustine, Joshua, Branagan, Andrew R., Flynn, Catherine A., Sarosiek, Shayna, Castillo, Jorge J., Wang, Jinhua, Buhrlage, Sara J., Gray, Nathanael S., Munshi, Nikhil C., Anderson, Kenneth C., Treon, Steven P., Yang, Guang
Publicado 2022

Targeting oncoproteins with a positive selection assay for protein degraders

por Koduri, Vidyasagar, Duplaquet, Leslie, Lampson, Benjamin L., Wang, Adam C., Sabet, Amin H., Ishoey, Mette, Paulk, Joshiawa, Teng, Mingxing, Harris, Isaac S., Endress, Jennifer E., Liu, Xiaoxi, Dasilva, Ethan, Paulo, Joao A., Briggs, Kimberly J., Doench, John G., Ott, Christopher J., Zhang, Tinghu, Donovan, Katherine A., Fischer, Eric S., Gygi, Steven P., Gray, Nathanael S., Bradner, James, Medin, Jeffrey A., Buhrlage, Sara J., Oser, Matthew G., Kaelin, William G.
Publicado 2021

Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability

por Paolella, Brenton R, Gibson, William J, Urbanski, Laura M, Alberta, John A, Zack, Travis I, Bandopadhayay, Pratiti, Nichols, Caitlin A, Agarwalla, Pankaj K, Brown, Meredith S, Lamothe, Rebecca, Yu, Yong, Choi, Peter S, Obeng, Esther A, Heckl, Dirk, Wei, Guo, Wang, Belinda, Tsherniak, Aviad, Vazquez, Francisca, Weir, Barbara A, Root, David E, Cowley, Glenn S, Buhrlage, Sara J, Stiles, Charles D, Ebert, Benjamin L, Hahn, William C, Reed, Robin, Beroukhim, Rameen
Publicado 2017

Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism

por Schauer, Nathan J., Liu, Xiaoxi, Magin, Robert S., Doherty, Laura M., Chan, Wai Cheung, Ficarro, Scott B., Hu, Wanyi, Roberts, Rebekka M., Iacob, Roxana E., Stolte, Björn, Giacomelli, Andrew O., Perera, Sumner, McKay, Kyle, Boswell, Sarah A., Weisberg, Ellen L., Ray, Arghya, Chauhan, Dharminder, Dhe-Paganon, Sirano, Anderson, Ken C., Griffin, James D., Li, Jianing, Hahn, William C., Sorger, Peter K., Engen, John R., Stegmaier, Kimberly, Marto, Jarrod A., Buhrlage, Sara J.
Publicado 2020

Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma

por Lee, Patrick C., Klaeger, Susan, Le, Phuong M., Korthauer, Keegan, Cheng, Jingwei, Ananthapadmanabhan, Varsha, Frost, Thomas C., Stevens, Jonathan D., Wong, Alan Y.L., Iorgulescu, J. Bryan, Tarren, Anna Y., Chea, Vipheaviny A., Carulli, Isabel P., Lemvigh, Camilla K., Pedersen, Christina B., Gartin, Ashley K., Sarkizova, Siranush, Wright, Kyle T., Li, Letitia W., Nomburg, Jason, Li, Shuqiang, Huang, Teddy, Liu, Xiaoxi, Pomerance, Lucas, Doherty, Laura M., Apffel, Annie M., Wallace, Luke J., Rachimi, Suzanna, Felt, Kristen D., Wolff, Jacquelyn O., Witten, Elizabeth, Zhang, Wandi, Neuberg, Donna, Lane, William J., Zhang, Guanglan, Olsen, Lars R., Thakuria, Manisha, Rodig, Scott J., Clauser, Karl R., Starrett, Gabriel J., Doench, John G., Buhrlage, Sara J., Carr, Steven A., DeCaprio, James A., Wu, Catherine J., Keskin, Derin B.
Publicado 2022