Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158

por Grobben, Yvonne, Uitdehaag, Joost C.M., Willemsen-Seegers, Nicole, Tabak, Werner W.A., de Man, Jos, Buijsman, Rogier C., Zaman, Guido J.R.
Publicado 2019

Identification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase

por Michels, Helen, Seinstra, Renée I., Uitdehaag, Joost C. M., Koopman, Mandy, van Faassen, Martijn, Martineau, Céline N., Kema, Ido P., Buijsman, Rogier, Nollen, Ellen A. A.
Publicado 2016

Screening of predicted synergistic multi-target therapies in glioblastoma identifies new treatment strategies

por Houweling, Megan, Giczewska, Anna, Abdul, Kulsoom, Nieuwenhuis, Ninke, Küçükosmanoglu, Asli, Pastuszak, Krzysztof, Buijsman, Rogier C, Wesseling, Pieter, Wedekind, Laurine, Noske, David, Supernat, Anna, Bailey, David, Watts, Colin, Wurdinger, Thomas, Westerman, Bart A
Publicado 2023

Comparison of the Cancer Gene Targeting and Biochemical Selectivities of All Targeted Kinase Inhibitors Approved for Clinical Use

por Uitdehaag, Joost C. M., de Roos, Jeroen A. D. M., van Doornmalen, Antoon M., Prinsen, Martine B. W., de Man, Jos, Tanizawa, Yoshinori, Kawase, Yusuke, Yoshino, Kohichiro, Buijsman, Rogier C., Zaman, Guido J. R.
Publicado 2014

Chemotherapy sensitivity testing on ovarian cancer cells isolated from malignant ascites

por den Ouden, Judith E., Zaman, Guido J.R., Dylus, Jelle, van Doornmalen, Antoon M., Mulder, Winfried R., Grobben, Yvonne, van Riel, Wilhelmina E., de Hullu, Joanne A., Buijsman, Rogier C., van Altena, Anne M.
Publicado 2020

Selective Targeting of CTNNB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs

por Uitdehaag, Joost C. M., de Roos, Jeroen A. D. M., van Doornmalen, Antoon M., Prinsen, Martine B. W., Spijkers-Hagelstein, Jill A. P., de Vetter, Judith R. F., de Man, Jos, Buijsman, Rogier C., Zaman, Guido J. R.
Publicado 2015

Stable aneuploid tumors cells are more sensitive to TTK inhibition than chromosomally unstable cell lines

por Libouban, Marion A.A., de Roos, Jeroen A.D.M., Uitdehaag, Joost C.M., Willemsen-Seegers, Nicole, Mainardi, Sara, Dylus, Jelle, de Man, Jos, Tops, Bastiaan, Meijerink, Jules P.P., Storchová, Zuzana, Buijsman, Rogier C., Medema, René H., Zaman, Guido J.R.
Publicado 2017

IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study

por Li, Yunlei, Buijs-Gladdines, Jessica G. C. A. M., Canté-Barrett, Kirsten, Stubbs, Andrew P., Vroegindeweij, Eric M., Smits, Willem K., van Marion, Ronald, Dinjens, Winand N. M., Horstmann, Martin, Kuiper, Roland P., Buijsman, Rogier C., Zaman, Guido J. R., van der Spek, Peter J., Pieters, Rob, Meijerink, Jules P. P.
Publicado 2016

Pharmacological validation of TDO as a target for Parkinson’s disease

por Perez‐Pardo, Paula, Grobben, Yvonne, Willemsen‐Seegers, Nicole, Hartog, Mitch, Tutone, Michaela, Muller, Michelle, Adolfs, Youri, Pasterkamp, Ronald Jeroen, Vu‐Pham, Diep, van Doornmalen, Antoon M., van Cauter, Freek, de Wit, Joeri, Gerard Sterrenburg, Jan, Uitdehaag, Joost C.M., de Man, Jos, Buijsman, Rogier C., Zaman, Guido J.R., Kraneveld, Aletta D.
Publicado 2021

Targeting Indoleamine 2,3-Dioxygenase in Cancer Models Using the Novel Small Molecule Inhibitor NTRC 3883-0

por Grobben, Yvonne, de Man, Jos, van Doornmalen, Antoon M., Muller, Michelle, Willemsen-Seegers, Nicole, Vu-Pham, Diep, Mulder, Winfried R., Prinsen, Martine B. W., de Wit, Joeri, Sterrenburg, Jan Gerard, van Cauter, Freek, den Ouden, Judith E., van Altena, Anne M., Massuger, Leon F., Uitdehaag, Joost C. M., Buijsman, Rogier C., Zaman, Guido J. R.
Publicado 2021