Overexpression of Cancer-Associated Stem Cell Gene OLFM4 in the Colonic Epithelium of Patients With Primary Sclerosing Cholangitis

por Neyazi, Mastura, Bharadwaj, Sraddha S, Bullers, Samuel, Varenyiova, Zofia, Travis, Simon, Arancibia-Cárcamo, Carolina V, Powrie, Fiona, Geremia, Alessandra
Publicado 2021

A Large Polysaccharide Produced by Helicobacter hepaticus Induces an Anti-inflammatory Gene Signature in Macrophages

por Danne, Camille, Ryzhakov, Grigory, Martínez-López, Maria, Ilott, Nicholas Edward, Franchini, Fanny, Cuskin, Fiona, Lowe, Elisabeth C., Bullers, Samuel J., Arthur, J. Simon C., Powrie, Fiona
Publicado 2017

Foxp3(+) T reg cells control psoriasiform inflammation by restraining an IFN-I–driven CD8(+) T cell response

por Stockenhuber, Krista, Hegazy, Ahmed N., West, Nathaniel R., Ilott, Nicholas E., Stockenhuber, Alexander, Bullers, Samuel J., Thornton, Emily E., Arnold, Isabelle C., Tucci, Andrea, Waldmann, Herman, Ogg, Graham S., Powrie, Fiona
Publicado 2018

Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation

por Ryzhakov, Grigory, Almuttaqi, Hannah, Corbin, Alastair L., Berthold, Dorothée L., Khoyratty, Tariq, Eames, Hayley L., Bullers, Samuel, Pearson, Claire, Ai, Zhichao, Zec, Kristina, Bonham, Sarah, Fischer, Roman, Jostins-Dean, Luke, Travis, Simon P. L., Kessler, Benedikt M., Udalova, Irina A.
Publicado 2021

Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis

por Ryzhakov, Grigory, West, Nathaniel R., Franchini, Fanny, Clare, Simon, Ilott, Nicholas E., Sansom, Stephen N., Bullers, Samuel J., Pearson, Claire, Costain, Alice, Vaughan-Jackson, Alun, Goettel, Jeremy A., Ermann, Joerg, Horwitz, Bruce H., Buti, Ludovico, Lu, Xin, Mukhopadhyay, Subhankar, Snapper, Scott B., Powrie, Fiona
Publicado 2018

A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice

por Hackstein, Carl-Philipp, Costigan, Dana, Drexhage, Linnea, Pearson, Claire, Bullers, Samuel, Ilott, Nicholas, Akther, Hossain Delowar, Gu, Yisu, FitzPatrick, Michael E. B., Harrison, Oliver J., Garner, Lucy C., Mann, Elizabeth H., Pandey, Sumeet, Friedrich, Matthias, Provine, Nicholas M., Uhlig, Holm H., Marchi, Emanuele, Powrie, Fiona, Klenerman, Paul, Thornton, Emily E.
Publicado 2022

Oncostatin M drives intestinal inflammation in mice and its abundance predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease

por West, Nathaniel R., Hegazy, Ahmed N., Owens, Benjamin M. J., Bullers, Samuel J., Linggi, Bryan, Buonocore, Sofia, Coccia, Margherita, Görtz, Dieter, This, Sébastien, Stockenhuber, Krista, Pott, Johanna, Friedrich, Matthias, Ryzhakov, Grigory, Baribaud, Frédéric, Brodmerkel, Carrie, Cieluch, Constanze, Rahman, Nahid, Müller-Newen, Gerhard, Owens, Raymond J., Kühl, Anja A., Maloy, Kevin J., Plevy, Scott E., Keshav, Satish, Travis, Simon P. L., Powrie, Fiona
Publicado 2017

IL-1-driven stromal–neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies

por Friedrich, Matthias, Pohin, Mathilde, Jackson, Matthew A., Korsunsky, Ilya, Bullers, Samuel J., Rue-Albrecht, Kevin, Christoforidou, Zoe, Sathananthan, Dharshan, Thomas, Tom, Ravindran, Rahul, Tandon, Ruchi, Peres, Raphael Sanches, Sharpe, Hannah, Wei, Kevin, Watts, Gerald F. M., Mann, Elizabeth H., Geremia, Alessandra, Attar, Moustafa, McCuaig, Sarah, Thomas, Lloyd, Collantes, Elena, Uhlig, Holm H., Sansom, Stephen N., Easton, Alistair, Raychaudhuri, Soumya, Travis, Simon P., Powrie, Fiona M.
Publicado 2021

Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice

por Wang, Lin, Aschenbrenner, Dominik, Zeng, Zhiyang, Cao, Xiya, Mayr, Daniel, Mehta, Meera, Capitani, Melania, Warner, Neil, Pan, Jie, Wang, Liren, Li, Qi, Zuo, Tao, Cohen-Kedar, Sarit, Lu, Jiawei, Ardy, Rico Chandra, Mulder, Daniel J., Dissanayake, Dilan, Peng, Kaiyue, Huang, Zhiheng, Li, Xiaoqin, Wang, Yuesheng, Wang, Xiaobing, Li, Shuchao, Bullers, Samuel, Gammage, Anís N., Warnatz, Klaus, Schiefer, Ana-Iris, Krivan, Gergely, Goda, Vera, Kahr, Walter H.A., Lemaire, Mathieu, Lu, Chien-Yi, Siddiqui, Iram, Surette, Michael G., Kotlarz, Daniel, Engelhardt, Karin R., Griffin, Helen R., Rottapel, Robert, Decaluwe, Hélène, Laxer, Ronald M., Proietti, Michele, Hambleton, Sophie, Elcombe, Suzanne, Guo, Cong-Hui, Grimbacher, Bodo, Dotan, Iris, Ng, Siew C., Freeman, Spencer A., Snapper, Scott B., Klein, Christoph, Boztug, Kaan, Huang, Ying, Li, Dali, Uhlig, Holm H., Muise, Aleixo M.
Publicado 2021