New strategies to inhibit KEAP1 and the Cul3-based E3 ubiquitin ligases

por Canning, Peter, Bullock, Alex N.
Publicado 2014

Targeting RIPK1,2,3 to combat inflammation

por Bullock, Alex N., Degterev, Alexei
Publicado 2015

Structural basis for the potent and selective binding of LDN-212854 to the BMP receptor kinase ALK2

por Williams, Eleanor, Bullock, Alex N.
Publicado 2018

Structural Basis for ASPP2 Recognition by the Tumor Suppressor p73

por Canning, Peter, von Delft, Frank, Bullock, Alex N.
Publicado 2012

Structural basis of Keap1 interactions with Nrf2

por Canning, Peter, Sorrell, Fiona J., Bullock, Alex N.
Publicado 2015

ALK2 Receptor Kinase Association with FKBP12.6 Is Structurally Conserved with the ALK2-FKBP12 Complex

por Williams, Eleanor, Riesebos, Elise, Kerr, Georgina, Bullock, Alex N.
Publicado 2021

Structural consequences of BMPR2 kinase domain mutations causing pulmonary arterial hypertension

por Chaikuad, Apirat, Thangaratnarajah, Chancievan, von Delft, Frank, Bullock, Alex N.
Publicado 2019

Fostering open collaboration in drug development for paediatric brain tumours

por Wong, Jong Fu, Brown, Elizabeth J., Williams, Eleanor, Bullock, Alex N.
Publicado 2019

Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase

por Chen, Zhuoyao, Picaud, Sarah, Filippakopoulos, Panagis, D'Angiolella, Vincenzo, Bullock, Alex N.
Publicado 2019

Structure of the SOCS4-ElonginB/C Complex Reveals a Distinct SOCS Box Interface and the Molecular Basis for SOCS-Dependent EGFR Degradation

por Bullock, Alex N., Rodriguez, Maria C., Debreczeni, Judit É., Songyang, Zhou, Knapp, Stefan
Publicado 2007

Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly

por Adamson, Roslin J., Payne, N Connor, Bartual, Sergio G., Mazitschek, Ralph, Bullock, Alex N.
Publicado 2023

Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation

por Schumacher, Frances-Rose, Sorrell, Fiona J., Alessi, Dario R., Bullock, Alex N., Kurz, Thimo
Publicado 2014

Structural Mechanisms Determining Inhibition of the Collagen Receptor DDR1 by Selective and Multi-Targeted Type II Kinase Inhibitors

por Canning, Peter, Tan, Li, Chu, Kiki, Lee, Sam W., Gray, Nathanael S., Bullock, Alex N.
Publicado 2014

Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding

por Dixon-Clarke, Sarah E., Elkins, Jonathan M., Cheng, S.-W. Grace, Morin, Gregg B., Bullock, Alex N.
Publicado 2015

A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis

por Kerr, Georgina, Sheldon, Helen, Chaikuad, Apirat, Alfano, Ivan, von Delft, Frank, Bullock, Alex N., Harris, Adrian L.
Publicado 2015

Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12

por Chen, Zhuoyao, Wasney, Gregory A., Picaud, Sarah, Filippakopoulos, Panagis, Vedadi, Masoud, D'Angiolella, Vincenzo, Bullock, Alex N.
Publicado 2020

Novel Quinazolinone Inhibitors of ALK2 Flip between Alternate Binding Modes: Structure–Activity Relationship, Structural Characterization, Kinase Profiling, and Cellular Proof of C...

por Hudson, Liam, Mui, James, Vázquez, Santiago, Carvalho, Diana M., Williams, Eleanor, Jones, Chris, Bullock, Alex N., Hoelder, Swen
Publicado 2018

Challenges and Opportunities for Drug Repositioning in Fibrodysplasia Ossificans Progressiva

por Ventura, Francesc, Williams, Eleanor, Ikeya, Makoto, Bullock, Alex N., ten Dijke, Peter, Goumans, Marie-José, Sanchez-Duffhues, Gonzalo
Publicado 2021

Molecular Architecture of the Ankyrin SOCS Box Family of Cul5-Dependent E3 Ubiquitin Ligases

por Muniz, João R.C., Guo, Kunde, Kershaw, Nadia J., Ayinampudi, Vikram, von Delft, Frank, Babon, Jeffrey J., Bullock, Alex N.
Publicado 2013

Small Molecules Dorsomorphin and LDN-193189 Inhibit Myostatin/GDF8 Signaling and Promote Functional Myoblast Differentiation

por Horbelt, Daniel, Boergermann, Jan H., Chaikuad, Apirat, Alfano, Ivan, Williams, Eleanor, Lukonin, Ilya, Timmel, Tobias, Bullock, Alex N., Knaus, Petra
Publicado 2015