Structure–Activity Studies Reveal the Oxazinone Ring Is a Determinant of Cytochrome P450 2B6 Activity Toward Efavirenz

por Cox, Philip M., Bumpus, Namandjé N.
Publicado 2014

Insights into protein post-translational modification landscapes of individual human cells by trapped ion mobility time-of-flight mass spectrometry

por Orsburn, Benjamin C., Yuan, Yuting, Bumpus, Namandjé N.
Publicado 2022

Biotransformation of Efavirenz and Proteomic Analysis of Cytochrome P450s and UDP-Glucuronosyltransferases in Mouse, Macaque, and Human Brain-Derived In Vitro Systems

por Wheeler, Abigail M., Orsburn, Benjamin C., Bumpus, Namandjé N.
Publicado 2023

Twelfth-Position Deuteration of Nevirapine Reduces 12-Hydroxy-Nevirapine Formation and Nevirapine-Induced Hepatocyte Death

por Heck, Carley J. S., Seneviratne, Herana Kamal, Bumpus, Namandjé N.
Publicado 2020

Naturally Occurring Mutations to Muscle-Type Creatine Kinase Impact Its Canonical and Pharmacological Activities in a Substrate-Dependent Manner In Vitro

por Mosher, Eric P., Eberhard, Colten D., Bumpus, Namandjé N.
Publicado 2021

Discovery of Genetic Variants of the Kinases That Activate Tenofovir in a Compartment-specific Manner

por Lade, Julie M., To, Elaine E., Hendrix, Craig W., Bumpus, Namandjé N.
Publicado 2015

Tenofovir Activation is Diminished in the Brain and Liver of Creatine Kinase Brain-Type Knockout Mice

por Eberhard, Colten D., Mosher, Eric P., Bumpus, Namandjé N., Orsburn, Benjamin C.
Publicado 2023

Spatial Distribution Profiles of Emtricitabine, Tenofovir, Efavirenz, and Rilpivirine in Murine Tissues Following In Vivo Dosing Correlate with Their Safety Profiles in Humans

por Seneviratne, Herana Kamal, Hamlin, Allyson N., Heck, Carley J. S., Bumpus, Namandjé N.
Publicado 2020

The SAGA HAT module is tethered by its SWIRM domain and modulates activity of the SAGA DUB module

por Haile, Sara T., Rahman, Sanim, Fields, James K., Orsburn, Benjamin C., Bumpus, Namandjé N., Wolberger, Cynthia
Publicado 2023

A Mechanistic In Vivo/Ex Vivo Pharmacokinetic‐Pharmacodynamic Model of Tenofovir for HIV Prevention

por Jayachandran, Priya, Garcia-Cremades, Maria, Vučićević, Katarina, Bumpus, Namandjé N., Anton, Peter, Hendrix, Craig, Savić, Radojka
Publicado 2021

Human Cyclophilin B Nuclease Activity Revealed via Nucleic Acid‐Based Electrochemical Sensors

por Clark, Vincent, Waters, Kelly, Orsburn, Ben, Bumpus, Namandjé N., Kundu, Nandini, Sczepanski, Jonathan T., Ray, Partha, Arroyo‐Currás, Netzahualcóyotl
Publicado 2022

Small Molecule Inhibition of SAMHD1 dNTPase by Tetramer Destabilization

por Seamon, Kyle J., Hansen, Erik C., Kadina, Anastasia P., Kashemirov, Boris A., McKenna, Charles E., Bumpus, Namandjé N., Stivers, James T.
Publicado 2014

Achieving a Deeper Understanding of Drug Metabolism and Responses Using Single-Cell Technologies

por Wheeler, Abigail M., Eberhard, Colten D., Mosher, Eric P., Yuan, Yuting, Wilkins, Hannah N., Seneviratne, Herana Kamal, Orsburn, Benjamin C., Bumpus, Namandjé N.
Publicado 2023

Utility of Different Adherence Measures for PrEP: Patterns and Incremental Value

por Abaasa, Andrew, Hendrix, Craig, Gandhi, Monica, Anderson, Peter, Kamali, Anatoli, Kibengo, Freddie, Sanders, Eduard J., Mutua, Gaudensia, Bumpus, Namandjé N., Priddy, Frances, Haberer, Jessica E.
Publicado 2017

HIV Protective Efficacy and Correlates of Tenofovir Blood Concentrations in a Clinical Trial of PrEP for HIV Prevention

por Donnell, Deborah, Baeten, Jared M., Bumpus, Namandjé N., Brantley, Justin, Bangsberg, David R., Haberer, Jessica E., Mujugira, Andrew, Mugo, Nelly, Ndase, Patrick, Hendrix, Craig, Celum, Connie
Publicado 2014

Transgender women on oral HIV pre‐exposure prophylaxis have significantly lower tenofovir and emtricitabine concentrations when also taking oestrogen when compared to cisgender men...

por Shieh, Eugenie, Marzinke, Mark A, Fuchs, Edward J, Hamlin, Allyson, Bakshi, Rahul, Aung, Wutyi, Breakey, Jennifer, Poteat, Tonia, Brown, Todd, Bumpus, Namandjé N, Hendrix, Craig W
Publicado 2019

Correlation between Compartmental Tenofovir Concentrations and an Ex Vivo Rectal Biopsy Model of Tissue Infectibility in the RMP-02/MTN-006 Phase 1 Study

por Richardson-Harman, Nicola, Hendrix, Craig W., Bumpus, Namandjé N., Mauck, Christine, Cranston, Ross D., Yang, Kuo, Elliott, Julie, Tanner, Karen, McGowan, Ian, Kashuba, Angela, Anton, Peter A.
Publicado 2014

Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism

por McGuire, Meredith R., Mukhopadhyay, Debaditya, Myers, Stephanie L., Mosher, Eric P., Brookheart, Rita T., Kammers, Kai, Sehgal, Alfica, Selen, Ebru S., Wolfgang, Michael J., Bumpus, Namandjé N., Espenshade, Peter J.
Publicado 2021

A mevalonate bypass system facilitates elucidation of plastid biology in malaria parasites

por Swift, Russell P., Rajaram, Krithika, Liu, Hans B., Dziedzic, Amanda, Jedlicka, Anne E., Roberts, Aleah D., Matthews, Krista A., Jhun, Hugo, Bumpus, Namandje N., Tewari, Shivendra G., Wallqvist, Anders, Prigge, Sean T.
Publicado 2020

MTN-001: Randomized Pharmacokinetic Cross-Over Study Comparing Tenofovir Vaginal Gel and Oral Tablets in Vaginal Tissue and Other Compartments

por Hendrix, Craig W., Chen, Beatrice A., Guddera, Vijayanand, Hoesley, Craig, Justman, Jessica, Nakabiito, Clemensia, Salata, Robert, Soto-Torres, Lydia, Patterson, Karen, Minnis, Alexandra M., Gandham, Sharavi, Gomez, Kailazarid, Richardson, Barbra A., Bumpus, Namandje N.
Publicado 2013