PET as a Translational Tool in Drug Development for Neuroscience Compounds

por Varrone, Andrea, Bundgaard, Christoffer, Bang‐Andersen, Benny
Publicado 2022

Brexpiprazole Alters Monoaminergic Systems following Repeated Administration: an in Vivo Electrophysiological Study

por Oosterhof, Chris A., Mansari, Mostafa El, Bundgaard, Christoffer, Blier, Pierre
Publicado 2015

Oral dosing of rodents using a palatable tablet

por Dhawan, Sandeep S., Xia, Shuang, Tait, David S., Bundgaard, Christoffer, Bowman, Ellen, Brown, Verity J.
Publicado 2018

From Pan-Reactive K(V)7 Channel Opener to Subtype Selective Opener/Inhibitor by Addition of a Methyl Group

por Blom, Sigrid Marie, Rottländer, Mario, Kehler, Jan, Bundgaard, Christoffer, Schmitt, Nicole, Jensen, Henrik Sindal
Publicado 2014

Target-Mediated Brain Tissue Binding for Small Molecule Inhibitors of Heat Shock Protein 90

por Badolo, Lassina, Thirstrup, Kenneth, Nielsen, Søren Møller, Püschl, Ask, Jensen, Thomas, Watson, Steve, Bundgaard, Christoffer
Publicado 2020

Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABA(A) receptors

por Falk-Petersen, Christina Birkedahl, Tsonkov, Tsonko M., Nielsen, Malene Sofie, Harpsøe, Kasper, Bundgaard, Christoffer, Frølund, Bente, Kristiansen, Uffe, Gloriam, David E., Wellendorph, Petrine
Publicado 2020

Characterization of [(11)C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain

por Yang, Kai-Chun, Stepanov, Vladimir, Amini, Nahid, Martinsson, Stefan, Takano, Akihiro, Nielsen, Jacob, Bundgaard, Christoffer, Bang-Andersen, Benny, Grimwood, Sarah, Halldin, Christer, Farde, Lars, Finnema, Sjoerd J.
Publicado 2016

Systemic administration of ivabradine, a hyperpolarization‐activated cyclic nucleotide‐gated channel inhibitor, blocks spontaneous absence seizures

por Iacone, Yasmine, Morais, Tatiana P., David, François, Delicata, Francis, Sandle, Joanna, Raffai, Timea, Parri, Harri Rheinallt, Weisser, Johan Juhl, Bundgaard, Christoffer, Klewe, Ib Vestergaard, Tamás, Gábor, Thomsen, Morten Skøtt, Crunelli, Vincenzo, Lőrincz, Magor L.
Publicado 2021

Unbound Brain-to-Plasma Partition Coefficient, K(p,uu,brain)—a Game Changing Parameter for CNS Drug Discovery and Development

por Loryan, Irena, Reichel, Andreas, Feng, Bo, Bundgaard, Christoffer, Shaffer, Christopher, Kalvass, Cory, Bednarczyk, Dallas, Morrison, Denise, Lesuisse, Dominique, Hoppe, Edmund, Terstappen, Georg C., Fischer, Holger, Di, Li, Colclough, Nicola, Summerfield, Scott, Buckley, Stephen T., Maurer, Tristan S., Fridén, Markus
Publicado 2022

Bitopic Binding Mode of an M(1) Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes

por Bradley, Sophie J., Molloy, Colin, Bundgaard, Christoffer, Mogg, Adrian J., Thompson, Karen J., Dwomoh, Louis, Sanger, Helen E., Crabtree, Michael D., Brooke, Simon M., Sexton, Patrick M., Felder, Christian C., Christopoulos, Arthur, Broad, Lisa M., Tobin, Andrew B., Langmead, Christopher J.
Publicado 2018

DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs in Vitro and in Vivo

por Thompson, Karen J., Khajehali, Elham, Bradley, Sophie J., Navarrete, Jovana S., Huang, Xi Ping, Slocum, Samuel, Jin, Jian, Liu, Jing, Xiong, Yan, Olsen, Reid H. J., Diberto, Jeffrey F., Boyt, Kristen M., Pina, Melanie M., Pati, Dipanwita, Molloy, Colin, Bundgaard, Christoffer, Sexton, Patrick M., Kash, Thomas L., Krashes, Michael J., Christopoulos, Arthur, Roth, Bryan L., Tobin, Andrew B.
Publicado 2018