Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit

por Fish, Paul V., Filippakopoulos, Panagis, Bish, Gerwyn, Brennan, Paul E., Bunnage, Mark E., Cook, Andrew S., Federov, Oleg, Gerstenberger, Brian S., Jones, Hannah, Knapp, Stefan, Marsden, Brian, Nocka, Karl, Owen, Dafydd R., Philpott, Martin, Picaud, Sarah, Primiano, Michael J., Ralph, Michael J., Sciammetta, Nunzio, Trzupek, John D.
Publicado 2012

Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains

por Hay, Duncan A., Fedorov, Oleg, Martin, Sarah, Singleton, Dean C., Tallant, Cynthia, Wells, Christopher, Picaud, Sarah, Philpott, Martin, Monteiro, Octovia P., Rogers, Catherine M., Conway, Stuart J., Rooney, Timothy P. C., Tumber, Anthony, Yapp, Clarence, Filippakopoulos, Panagis, Bunnage, Mark E., Müller, Susanne, Knapp, Stefan, Schofield, Christopher J., Brennan, Paul E.
Publicado 2014

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance

por Fedorov, Oleg, Castex, Josefina, Tallant, Cynthia, Owen, Dafydd R., Martin, Sarah, Aldeghi, Matteo, Monteiro, Octovia, Filippakopoulos, Panagis, Picaud, Sarah, Trzupek, John D., Gerstenberger, Brian S., Bountra, Chas, Willmann, Dominica, Wells, Christopher, Philpott, Martin, Rogers, Catherine, Biggin, Philip C., Brennan, Paul E., Bunnage, Mark E., Schüle, Roland, Günther, Thomas, Knapp, Stefan, Müller, Susanne
Publicado 2015

Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists

por Liu, Shenping, Dakin, Leslie A., Xing, Li, Withka, Jane M., Sahasrabudhe, Parag V., Li, Wei, Banker, Mary Ellen, Balbo, Paul, Shanker, Suman, Chrunyk, Boris A., Guo, Zuojun, Chen, Jinshan M., Young, Jennifer A., Bai, Guoyun, Starr, Jeremy T., Wright, Stephen W., Bussenius, Joerg, Tan, Sheng, Gopalsamy, Ariamala, Lefker, Bruce A., Vincent, Fabien, Jones, Lyn H., Xu, Hua, Hoth, Lise R., Geoghegan, Kieran F., Qiu, Xiayang, Bunnage, Mark E., Thorarensen, Atli
Publicado 2016

Donated chemical probes for open science

por Müller, Susanne, Ackloo, Suzanne, Arrowsmith, Cheryl H, Bauser, Marcus, Baryza, Jeremy L, Blagg, Julian, Böttcher, Jark, Bountra, Chas, Brown, Peter J, Bunnage, Mark E, Carter, Adrian J, Damerell, David, Dötsch, Volker, Drewry, David H, Edwards, Aled M, Edwards, James, Elkins, Jon M, Fischer, Christian, Frye, Stephen V, Gollner, Andreas, Grimshaw, Charles E, IJzerman, Adriaan, Hanke, Thomas, Hartung, Ingo V, Hitchcock, Steve, Howe, Trevor, Hughes, Terry V, Laufer, Stefan, Li, Volkhart MJ, Liras, Spiros, Marsden, Brian D, Matsui, Hisanori, Mathias, John, O'Hagan, Ronan C, Owen, Dafydd R, Pande, Vineet, Rauh, Daniel, Rosenberg, Saul H, Roth, Bryan L, Schneider, Natalie S, Scholten, Cora, Singh Saikatendu, Kumar, Simeonov, Anton, Takizawa, Masayuki, Tse, Chris, Thompson, Paul R, Treiber, Daniel K, Viana, Amélia YI, Wells, Carrow I, Willson, Timothy M, Zuercher, William J, Knapp, Stefan, Mueller-Fahrnow, Anke
Publicado 2018