TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation

por Magno, Lorenza, Bunney, Tom D., Mead, Emma, Svensson, Fredrik, Bictash, Magda N.
Publicado 2021

Targeting the Src Pathway Enhances the Efficacy of Selective FGFR Inhibitors in Urothelial Cancers with FGFR3 Alterations

por Lima, Nadia Carvalho, Atkinson, Eliza, Bunney, Tom D., Katan, Matilda, Huang, Paul H.
Publicado 2020

Dynamic Allostery in PLCγ1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMR

por Koss, Hans, Bunney, Tom D., Esposito, Diego, Martins, Marta, Katan, Matilda, Driscoll, Paul C.
Publicado 2018

Crystal Structure of the Human, FIC-Domain Containing Protein HYPE and Implications for Its Functions

por Bunney, Tom D., Cole, Ambrose R., Broncel, Malgorzata, Esposito, Diego, Tate, Edward W., Katan, Matilda
Publicado 2014

Characterization of the membrane interactions of phospholipase Cγ reveals key features of the active enzyme

por Le Huray, Kyle I. P., Bunney, Tom D., Pinotsis, Nikos, Kalli, Antreas C., Katan, Matilda
Publicado 2022

NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 3 in apo state and in complex with inhibitor PD173074

por Sanfelice, Domenico, Koss, Hans, Bunney, Tom D., Thompson, Gary S., Farrell, Brendan, Katan, Matilda, Breeze, Alexander L.
Publicado 2018

Time-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCγ1

por Perdios, Louis, Bunney, Tom D., Warren, Sean C., Dunsby, Christopher, French, Paul M.W., Tate, Edward W., Katan, Matilda
Publicado 2016

Structural and Functional Integration of the PLCγ Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation

por Bunney, Tom D., Esposito, Diego, Mas-Droux, Corine, Lamber, Ekatarina, Baxendale, Rhona W., Martins, Marta, Cole, Ambrose, Svergun, Dmitri, Driscoll, Paul C., Katan, Matilda
Publicado 2012

Rac Regulates Its Effector Phospholipase Cγ(2) through Interaction with a Split Pleckstrin Homology Domain

por Walliser, Claudia, Retlich, Michael, Harris, Richard, Everett, Katy L., Josephs, Michelle B., Vatter, Petra, Esposito, Diego, Driscoll, Paul C., Katan, Matilda, Gierschik, Peter, Bunney, Tom D.
Publicado 2008

The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study

por Bunney, Tom D., Wan, Shunzhou, Thiyagarajan, Nethaji, Sutto, Ludovico, Williams, Sarah V., Ashford, Paul, Koss, Hans, Knowles, Margaret A., Gervasio, Francesco L., Coveney, Peter V., Katan, Matilda
Publicado 2015

Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET

por Perdios, Louis, Lowe, Alan R., Saladino, Giorgio, Bunney, Tom D., Thiyagarajan, Nethaji, Alexandrov, Yuriy, Dunsby, Christopher, French, Paul M. W., Chin, Jason W., Gervasio, Francesco Luigi, Tate, Edward W., Katan, Matilda
Publicado 2017

Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System

por Bunney, Tom D., Inglis, Alison J., Sanfelice, Domenico, Farrell, Brendan, Kerr, Christopher J., Thompson, Gary S., Masson, Glenn R., Thiyagarajan, Nethaji, Svergun, Dmitri I., Williams, Roger L., Breeze, Alexander L., Katan, Matilda
Publicado 2018

Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes

por Liu, Yang, Bunney, Tom D., Khosa, Sakshi, Macé, Kévin, Beckenbauer, Katharina, Askwith, Trevor, Maslen, Sarah, Stubbs, Christopher, de Oliveira, Taiana M., Sader, Kasim, Skehel, Mark, Gavin, Anne-Claude, Phillips, Christopher, Katan, Matilda
Publicado 2020

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use

por Patani, Harshnira, Bunney, Tom D., Thiyagarajan, Nethaji, Norman, Richard A., Ogg, Derek, Breed, Jason, Ashford, Paul, Potterton, Andrew, Edwards, Mina, Williams, Sarah V., Thomson, Gary S., Pang, Camilla S.M., Knowles, Margaret A., Breeze, Alexander L., Orengo, Christine, Phillips, Chris, Katan, Matilda
Publicado 2016

Severe Autoinflammatory Manifestations and Antibody Deficiency Due to Novel Hypermorphic PLCG2 Mutations

por Martín-Nalda, Andrea, Fortuny, Claudia, Rey, Lourdes, Bunney, Tom D., Alsina, Laia, Esteve-Solé, Ana, Bull, Daniel, Anton, Maria Carmen, Basagaña, María, Casals, Ferran, Deyá, Angela, García-Prat, Marina, Gimeno, Ramon, Juan, Manel, Martinez-Banaclocha, Helios, Martinez-Garcia, Juan J, Mensa-Vilaró, Anna, Rabionet, Raquel, Martin-Begue, Nieves, Rudilla, Francesc, Yagüe, Jordi, Estivill, Xavier, García-Patos, Vicente, Pujol, Ramon M., Soler-Palacín, Pere, Katan, Matilda, Pelegrín, Pablo, Colobran, Roger, Vicente, Asun, Arostegui, Juan I.
Publicado 2020

A small molecule PI3Kα activator for cardioprotection and neuroregeneration

por Gong, Grace Q, Bilanges, Benoit, Allsop, Ben, Masson, Glenn R, Roberton, Victoria, Askwith, Trevor, Oxenford, Sally, Madsen, Ralitsa R, Conduit, Sarah E, Bellini, Dom, Fitzek, Martina, Collier, Matt, Najam, Osman, He, Zhenhe, Wahab, Ben, McLaughlin, Stephen H, Chan, AW Edith, Feierberg, Isabella, Madin, Andrew, Morelli, Daniele, Bhamra, Amandeep, Vinciauskaite, Vanesa, Anderson, Karen E., Surinova, Silvia, Pinotsis, Nikos, Lopez-Guadamillas, Elena, Wilcox, Matthew, Hooper, Alice, Patel, Chandni, Whitehead, Maria A, Bunney, Tom D, Stephens, Len R, Hawkins, Phillip T, Katan, Matilda, Yellon, Derek M, Davidson, Sean M, Smith, David M, Phillips, James B, Angell, Richard, Williams, Roger L, Vanhaesebroeck, Bart
Publicado 2023

Recurrent PTPRB and PLCG1 mutations in angiosarcoma

por Behjati, Sam, Tarpey, Patrick S, Sheldon, Helen, Martincorena, Inigo, Van Loo, Peter, Gundem, Gunes, Wedge, David C, Ramakrishna, Manasa, Cooke, Susanna L, Pillay, Nischalan, Vollan, Hans Kristian M, Papaemmanuil, Elli, Koss, Hans, Bunney, Tom D, Hardy, Claire, Joseph, Olivia R, Martin, Sancha, Mudie, Laura, Butler, Adam, Teague, Jon W, Patil, Meena, Steers, Graham, Cao, Yu, Gumbs, Curtis, Ingram, Davis, Lazar, Alexander J, Little, Latasha, Mahadeshwar, Harshad, Protopopov, Alexei, Al Sannaa, Ghadah A, Seth, Sahil, Song, Xingzhi, Tang, Jiabin, Zhang, Jianhua, Ravi, Vinod, Torres, Keila E, Khatri, Bhavisha, Halai, Dina, Roxanis, Ioannis, Baumhoer, Daniel, Tirabosco, Roberto, Amary, M Fernanda, Boshoff, Chris, McDermott, Ultan, Katan, Matilda, Stratton, Michael R, Futreal, P Andrew, Flanagan, Adrienne M, Harris, Adrian, Campbell, Peter J
Publicado 2014