The SCF(FBW7) ubiquitin ligase complex as a tumor suppressor in T cell leukemia

por Thompson, Benjamin J., Buonamici, Silvia, Sulis, Maria Luisa, Palomero, Teresa, Vilimas, Tomas, Basso, Giuseppe, Ferrando, Adolfo, Aifantis, Iannis
Publicado 2007

Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7

por Thompson, Benjamin J., Jankovic, Vladimir, Gao, Jie, Buonamici, Silvia, Vest, Alan, Lee, Jennifer May, Zavadil, Jiri, Nimer, Stephen D., Aifantis, Iannis
Publicado 2008

Intron retention is a hallmark and spliceosome represents a therapeutic vulnerability in aggressive prostate cancer

por Zhang, Dingxiao, Hu, Qiang, Liu, Xiaozhuo, Ji, Yibing, Chao, Hsueh-Ping, Liu, Yan, Tracz, Amanda, Kirk, Jason, Buonamici, Silvia, Zhu, Ping, Wang, Jianmin, Liu, Song, Tang, Dean G.
Publicado 2020

The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action

por Finci, Lorenzo I., Zhang, Xiaofeng, Huang, Xiuliang, Zhou, Qiang, Tsai, Jennifer, Teng, Teng, Agrawal, Anant, Chan, Betty, Irwin, Sean, Karr, Craig, Cook, Andrew, Zhu, Ping, Reynolds, Dominic, Smith, Peter G., Fekkes, Peter, Buonamici, Silvia, Larsen, Nicholas A.
Publicado 2018

A novel tumor suppressor function for the Notch pathway in myeloid leukemia

por Klinakis, Apostolos, Lobry, Camille, Abdel-Wahab, Omar, Oh, Philmo, Haeno, Hiroshi, Buonamici, Silvia, van De Walle, Inge, Cathelin, Severine, Trimarchi, Thomas, Araldi, Elisa, Liu, Cynthia, Ibrahim, Sherif, Beran, Miroslav, Zavadil, Jiri, Efstratiadis, Argiris, Taghon, Tom, Michor, Franziska, Levine, Ross L., Aifantis, Iannis
Publicado 2011

Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators

por Aird, Daniel, Teng, Teng, Huang, Chia-Ling, Pazolli, Ermira, Banka, Deepti, Cheung-Ong, Kahlin, Eifert, Cheryl, Furman, Craig, Wu, Zhenhua Jeremy, Seiler, Michael, Buonamici, Silvia, Fekkes, Peter, Karr, Craig, Palacino, James, Park, Eunice, Smith, Peter G., Yu, Lihua, Mizui, Yoshiharu, Warmuth, Markus, Chicas, Agustin, Corson, Laura, Zhu, Ping
Publicado 2019

Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma

por Sciarrillo, Rocco, Wojtuszkiewicz, Anna, El Hassouni, Btissame, Funel, Niccola, Gandellini, Paolo, Lagerweij, Tonny, Buonamici, Silvia, Blijlevens, Maxime, Zeeuw van der Laan, Eveline A., Zaffaroni, Nadia, Deraco, Marcello, Kusamura, Shigeki, Würdinger, Tom, Peters, Godefridus J., Molthoff, Carla F.M., Jansen, Gerrit, Kaspers, Gertjan J.L., Cloos, Jacqueline, Giovannetti, Elisa
Publicado 2018

Modulation of splicing catalysis for therapeutic targeting of leukemias with spliceosomal mutations

por Lee, Stanley Chun-Wei, Dvinge, Heidi, Kim, Eunhee, Cho, Hana, Micol, Jean-Baptiste, Chung, Young Rock, Durham, Benjamin H., Yoshimi, Akihide, Kim, Young Joon, Thomas, Michael, Lobry, Camille, Chen, Chun-Wei, Pastore, Alessandro, Taylor, Justin, Wang, Xujun, Krivtsov, Andrei, Armstrong, Scott A., Palacino, James, Buonamici, Silvia, Smith, Peter G., Bradley, Robert K., Abdel-Wahab, Omar
Publicado 2016

Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex

por Teng, Teng, Tsai, Jennifer HC, Puyang, Xiaoling, Seiler, Michael, Peng, Shouyong, Prajapati, Sudeep, Aird, Daniel, Buonamici, Silvia, Caleb, Benjamin, Chan, Betty, Corson, Laura, Feala, Jacob, Fekkes, Peter, Gerard, Baudouin, Karr, Craig, Korpal, Manav, Liu, Xiang, T. Lowe, Jason, Mizui, Yoshiharu, Palacino, James, Park, Eunice, Smith, Peter G., Subramanian, Vanitha, Wu, Zhenhua Jeremy, Zou, Jian, Yu, Lihua, Chicas, Agustin, Warmuth, Markus, Larsen, Nicholas, Zhu, Ping
Publicado 2017

Sex-Biased ZRSR2 Mutations in Myeloid Malignancies Impair Plasmacytoid Dendritic Cell Activation and Apoptosis

por Togami, Katsuhiro, Chung, Sun Sook, Madan, Vikas, Booth, Christopher A.G., Kenyon, Christopher M., Cabal-Hierro, Lucia, Taylor, Justin, Kim, Sunhee S., Griffin, Gabriel K., Ghandi, Mahmoud, Li, Jia, Li, Yvonne Y., Angelot-Delettre, Fanny, Biichle, Sabeha, Seiler, Michael, Buonamici, Silvia, Lovitch, Scott B., Louissaint, Abner, Morgan, Elizabeth A., Jardin, Fabrice, Piccaluga, Pier Paolo, Weinstock, David M., Hammerman, Peter S., Yang, Henry, Konopleva, Marina, Pemmaraju, Naveen, Garnache-Ottou, Francine, Abdel-Wahab, Omar, Koeffler, H. Phillip, Lane, Andrew A.
Publicado 2022

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4

por Tzelepis, Konstantinos, De Braekeleer, Etienne, Aspris, Demetrios, Barbieri, Isaia, Vijayabaskar, M. S., Liu, Wen-Hsin, Gozdecka, Malgorzata, Metzakopian, Emmanouil, Toop, Hamish D., Dudek, Monika, Robson, Samuel C., Hermida-Prado, Francisco, Yang, Yu Hsuen, Babaei-Jadidi, Roya, Garyfallos, Dimitrios A., Ponstingl, Hannes, Dias, Joao M. L., Gallipoli, Paolo, Seiler, Michael, Buonamici, Silvia, Vick, Binje, Bannister, Andrew J., Rad, Roland, Prinjha, Rab K., Marioni, John C., Huntly, Brian, Batson, Jennifer, Morris, Jonathan C., Pina, Cristina, Bradley, Allan, Jeremias, Irmela, Bates, David O., Yusa, Kosuke, Kouzarides, Tony, Vassiliou, George S.
Publicado 2018