Deletion of PKCε Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse β-Cells

por Cantley, James, Burchfield, James G., Pearson, Gemma L., Schmitz-Peiffer, Carsten, Leitges, Michael, Biden, Trevor J.
Publicado 2009

Autoencoder-based cluster ensembles for single-cell RNA-seq data analysis

por Geddes, Thomas A., Kim, Taiyun, Nan, Lihao, Burchfield, James G., Yang, Jean Y. H., Tao, Dacheng, Yang, Pengyi
Publicado 2019

SnapKin: a snapshot deep learning ensemble for kinase-substrate prediction from phosphoproteomics data

por Xiao, Di, Lin, Michael, Liu, Chunlei, Geddes, Thomas A, Burchfield, James G, Parker, Benjamin L, Humphrey, Sean J, Yang, Pengyi
Publicado 2023

The Role of the Niemann-Pick Disease, Type C1 Protein in Adipocyte Insulin Action

por Fletcher, Rachael, Gribben, Christopher, Ma, Xuiquan, Burchfield, James G., Thomas, Kristen C., Krycer, James R., James, David E., Fazakerley, Daniel J.
Publicado 2014

Deep Proteome Profiling of White Adipose Tissue Reveals Marked Conservation and Distinct Features Between Different Anatomical Depots

por Madsen, Søren, Nelson, Marin E., Deshpande, Vinita, Humphrey, Sean J., Cooke, Kristen C., Howell, Anna, Diaz-Vegas, Alexis, Burchfield, James G., Stöckli, Jacqueline, James, David E.
Publicado 2023

Signaling Heterogeneity is Defined by Pathway Architecture and Intercellular Variability in Protein Expression

por Norris, Dougall, Yang, Pengyi, Shin, Sung-Young, Kearney, Alison L., Kim, Hani Jieun, Geddes, Thomas, Senior, Alistair M., Fazakerley, Daniel J., Nguyen, Lan K., James, David E., Burchfield, James G.
Publicado 2021

Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation

por Fazakerley, Daniel J., Minard, Annabel Y., Krycer, James R., Thomas, Kristen C., Stöckli, Jacqueline, Harney, Dylan. J., Burchfield, James G., Maghzal, Ghassan J., Caldwell, Stuart T., Hartley, Richard C., Stocker, Roland, Murphy, Michael P., James, David E.
Publicado 2018

Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate

por Duan, Xiaowen, Norris, Dougall M., Humphrey, Sean J., Yang, Pengyi, Cooke, Kristen C., Bultitude, Will P., Parker, Benjamin L., Conway, Olivia J., Burchfield, James G., Krycer, James R., Brodsky, Frances M., James, David E., Fazakerley, Daniel J.
Publicado 2022

Glucose Homeostasis in Mice Is Transglutaminase 2 Independent

por Iismaa, Siiri E., Aplin, Mark, Holman, Sara, Yiu, Ting W., Jackson, Kristy, Burchfield, James G., Mitchell, Christopher J., O’Reilly, Liam, Davenport, Aimee, Cantley, James, Schmitz-Peiffer, Carsten, Biden, Trevor J., Cooney, Gregory J., Graham, Robert M.
Publicado 2013

Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumor Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes

por Fazakerley, Daniel J., Naghiloo, Sheyda, Chaudhuri, Rima, Koumanov, Françoise, Burchfield, James G., Thomas, Kristen C., Krycer, James R., Prior, Matthew J., Parker, Ben L., Murrow, Beverley A., Stöckli, Jacqueline, Meoli, Christopher C., Holman, Geoffrey D., James, David E.
Publicado 2015

Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis

por Kearney, Alison L, Norris, Dougall M, Ghomlaghi, Milad, Kin Lok Wong, Martin, Humphrey, Sean J, Carroll, Luke, Yang, Guang, Cooke, Kristen C, Yang, Pengyi, Geddes, Thomas A, Shin, Sungyoung, Fazakerley, Daniel J, Nguyen, Lan K, James, David E, Burchfield, James G
Publicado 2021

A high-content endogenous GLUT4 trafficking assay reveals new aspects of adipocyte biology

por Diaz-Vegas, Alexis, Norris, Dougall M, Jall-Rogg, Sigrid, Cooke, Kristen C, Conway, Olivia J, Shun-Shion, Amber S, Duan, Xiaowen, Potter, Meg, van Gerwen, Julian, Baird, Harry JM, Humphrey, Sean J, James, David E, Fazakerley, Daniel J, Burchfield, James G
Publicado 2022

Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance

por Fazakerley, Daniel J., van Gerwen, Julian, Cooke, Kristen C., Duan, Xiaowen, Needham, Elise J., Díaz-Vegas, Alexis, Madsen, Søren, Norris, Dougall M., Shun-Shion, Amber S., Krycer, James R., Burchfield, James G., Yang, Pengyi, Wade, Mark R., Brozinick, Joseph T., James, David E., Humphrey, Sean J.
Publicado 2023

Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle

por Diaz-Vegas, Alexis, Madsen, Soren, Cooke, Kristen C., Carroll, Luke, Khor, Jasmine X. Y., Turner, Nigel, Lim, Xin Ying, Astore, Miro A., Morris, Jonathan, Don, Anthony, Garfield, Amanda, Zarini, Simona, Zemski Berry, Karin A., Ryan, Andrew, Bergman, Bryan C., Brozinick, Joseph T., James, David E., Burchfield, James G.
Publicado 2023

Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2

por Aji, Gulibositan, Huang, Yu, Ng, Mei Li, Wang, Wei, Lan, Tian, Li, Min, Li, Yufei, Chen, Qi, Li, Rui, Yan, Sishan, Tran, Collin, Burchfield, James G., Couttas, Timothy A., Chen, Jinbiao, Chung, Long Hoa, Liu, Da, Wadham, Carol, Hogg, Philip J., Gao, Xin, Vadas, Mathew A., Gamble, Jennifer R., Don, Anthony S., Xia, Pu, Qi, Yanfei
Publicado 2020

Global redox proteome and phosphoproteome analysis reveals redox switch in Akt

por Su, Zhiduan, Burchfield, James G., Yang, Pengyi, Humphrey, Sean J., Yang, Guang, Francis, Deanne, Yasmin, Sabina, Shin, Sung-Young, Norris, Dougall M., Kearney, Alison L., Astore, Miro A., Scavuzzo, Jonathan, Fisher-Wellman, Kelsey H., Wang, Qiao-Ping, Parker, Benjamin L., Neely, G. Gregory, Vafaee, Fatemeh, Chiu, Joyce, Yeo, Reichelle, Hogg, Philip J., Fazakerley, Daniel J., Nguyen, Lan K., Kuyucak, Serdar, James, David E.
Publicado 2019

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance

por Fazakerley, Daniel J, Chaudhuri, Rima, Yang, Pengyi, Maghzal, Ghassan J, Thomas, Kristen C, Krycer, James R, Humphrey, Sean J, Parker, Benjamin L, Fisher-Wellman, Kelsey H, Meoli, Christopher C, Hoffman, Nolan J, Diskin, Ciana, Burchfield, James G, Cowley, Mark J, Kaplan, Warren, Modrusan, Zora, Kolumam, Ganesh, Yang, Jean YH, Chen, Daniel L, Samocha-Bonet, Dorit, Greenfield, Jerry R, Hoehn, Kyle L, Stocker, Roland, James, David E
Publicado 2018