Brd2 haploinsufficiency extends lifespan and healthspan in C57B6/J mice

por Pathak, Shilpa, Stewart, William C. L., Burd, Christin E., Hester, Mark E., Greenberg, David A.
Publicado 2020

Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk

por Burd, Christin E., Jeck, William R., Liu, Yan, Sanoff, Hanna K., Wang, Zefeng, Sharpless, Norman E.
Publicado 2010

Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms

por Burd, Christin E., Gill, Matthew S., Niedernhofer, Laura J., Robbins, Paul D., Austad, Steven N., Barzilai, Nir, Kirkland, James L.
Publicado 2016

Melanoma-associated mutants within the serine-rich domain of PAK5 direct kinase activity to mitogenic pathways

por LaPak, Kyle M., Vroom, Dennis C., Garg, Ayush A., Guan, Xiangnan, Hays, John L., Song, Jonathan W., Burd, Christin E.
Publicado 2018

INK4/ARF Transcript Expression Is Associated with Chromosome 9p21 Variants Linked to Atherosclerosis

por Liu, Yan, Sanoff, Hanna K., Cho, Hyunsoon, Burd, Christin E., Torrice, Chad, Mohlke, Karen L., Ibrahim, Joseph G., Thomas, Nancy E., Sharpless, Norman E.
Publicado 2009

Selinexor, a selective inhibitor of nuclear export (SINE), shows enhanced activity in combination with PD-1/PD-L1 blockade in syngeneic murine models of colon cancer and melanoma

por Farren, Matthew R, Shakya, Reena, Hennessey, Rebecca, Mace, Thomas, Yang, Jennifer, Elnaggar, Omar, Young, Gregory, Landesman, Yosef, Carlson, Robert, Elloul, Sivan, Crochiere, Marsha, Burd, Christin, Lesinski, Gregory
Publicado 2015

An oncogenic Ezh2 mutation cooperates with particular genetic alterations to induce tumors in mice and redistributes H3K27 trimethylation throughout the genome

por Souroullas, George P., Jeck, William R., Parker, Joel S., Simon, Jeremy M., Liu, Jie-Yu, Paulk, Joshiawa, Xiong, Jessie, Clark, Kelly S., Fedoriw, Yuri, Qi, Jun, Burd, Christin E., Bradner, James E., Sharpless, Norman E.
Publicado 2016

Ran Binding Protein 9 (RanBP9) is a novel mediator of cellular DNA damage response in lung cancer cells

por Palmieri, Dario, Scarpa, Mario, Tessari, Anna, Uka, Rexhep, Amari, Foued, Lee, Cindy, Richmond, Timothy, Foray, Claudia, Sheetz, Tyler, Braddom, Ashley, Burd, Christin E., Parvin, Jeffrey D., Ludwig, Thomas, Croce, Carlo M., Coppola, Vincenzo
Publicado 2016

UVB mutagenesis differs in Nras- and Braf-mutant mouse models of melanoma

por Bowman, Robert L, Hennessey, Rebecca C, Weiss, Tirzah J, Tallman, David A, Crawford, Emma R, Murphy, Brandon M, Webb, Amy, Zhang, Souhui, La Perle, Krista MD, Burd, Craig J, Levine, Ross L, Shain, A Hunter, Burd, Christin E
Publicado 2021

Cell‐intrinsic melanin fails to protect melanocytes from ultraviolet‐mutagenesis in the absence of epidermal melanin

por Weiss, Tirzah J., Crawford, Emma R., Posada, Valentina, Rahman, Hafeez, Liu, Tong, Murphy, Brandon M., Arnold, Tiffany E., Gray, Shannon, Hu, Zhexuan, Hennessey, Rebecca C., Yu, Lianbo, D'Orazio, John A., Burd, Craig J., Zippin, Jonathan H., Grossman, Douglas, Burd, Christin E.
Publicado 2022

Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice

por Yousefzadeh, Matthew J., Zhao, Jing, Bukata, Christina, Wade, Erin A., McGowan, Sara J., Angelini, Luise A., Bank, Michael P., Gurkar, Aditi U., McGuckian, Collin A., Calubag, Mariah F., Kato, Jonathan I., Burd, Christin E., Robbins, Paul D., Niedernhofer, Laura J.
Publicado 2020

Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation

por Murphy, Brandon M., Terrell, Elizabeth M., Chirasani, Venkat R., Weiss, Tirzah J., Lew, Rachel E., Holderbaum, Andrea M., Dhakal, Aastha, Posada, Valentina, Fort, Marie, Bodnar, Michael S., Carey, Leiah M., Chen, Min, Burd, Craig J., Coppola, Vincenzo, Morrison, Deborah K., Campbell, Sharon L., Burd, Christin E.
Publicado 2022

Fisetin is a senotherapeutic that extends health and lifespan

por Yousefzadeh, Matthew J., Zhu, Yi, McGowan, Sara J., Angelini, Luise, Fuhrmann-Stroissnigg, Heike, Xu, Ming, Ling, Yuan Yuan, Melos, Kendra I., Pirtskhalava, Tamar, Inman, Christina L., McGuckian, Collin, Wade, Erin A., Kato, Jonathon I., Grassi, Diego, Wentworth, Mark, Burd, Christin E., Arriaga, Edgar A., Ladiges, Warren L., Tchkonia, Tamara, Kirkland, James L., Robbins, Paul D., Niedernhofer, Laura J.
Publicado 2018

Co‐targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor‐resistant melanoma

por Echevarría‐Vargas, Ileabett M, Reyes‐Uribe, Patricia I, Guterres, Adam N, Yin, Xiangfan, Kossenkov, Andrew V, Liu, Qin, Zhang, Gao, Krepler, Clemens, Cheng, Chaoran, Wei, Zhi, Somasundaram, Rajasekharan, Karakousis, Giorgos, Xu, Wei, Morrissette, Jennifer JD, Lu, Yiling, Mills, Gordon B, Sullivan, Ryan J, Benchun, Miao, Frederick, Dennie T, Boland, Genevieve, Flaherty, Keith T, Weeraratna, Ashani T, Herlyn, Meenhard, Amaravadi, Ravi, Schuchter, Lynn M, Burd, Christin E, Aplin, Andrew E, Xu, Xiaowei, Villanueva, Jessie
Publicado 2018

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging

por Robinson, Andria R., Yousefzadeh, Matthew J., Rozgaja, Tania A., Wang, Jin, Li, Xuesen, Tilstra, Jeremy S., Feldman, Chelsea H., Gregg, Siobhán Q., Johnson, Caroline H., Skoda, Erin M., Frantz, Marie-Céline, Bell-Temin, Harris, Pope-Varsalona, Hannah, Gurkar, Aditi U., Nasto, Luigi A., Robinson, Renã A.S., Fuhrmann-Stroissnigg, Heike, Czerwinska, Jolanta, McGowan, Sara J., Cantu-Medellin, Nadiezhda, Harris, Jamie B., Maniar, Salony, Ross, Mark A., Trussoni, Christy E., LaRusso, Nicholas F., Cifuentes-Pagano, Eugenia, Pagano, Patrick J., Tudek, Barbara, Vo, Nam V., Rigatti, Lora H., Opresko, Patricia L., Stolz, Donna B., Watkins, Simon C., Burd, Christin E., Croix, Claudette M. St., Siuzdak, Gary, Yates, Nathan A., Robbins, Paul D., Wang, Yinsheng, Wipf, Peter, Kelley, Eric E., Niedernhofer, Laura J.
Publicado 2018