DIPG-37. TRANSCRIPTIONAL, EPIGENETIC, AND IMMUNOLOGICAL FEATURES OF PAEDIATRIC-TYPE H3 K27-ALTERED DIFFUSE MIDLINE GLIOMAS ORIGINATING FROM DIFFERENT BRAIN LOCATIONS

por Grabovska, Yura, Mackay, Alan, Pereira, Rita, Sejdiu, Drenusha, Burford, Anna, Temelso, Sara, Clarke, Matt, Jones, Chris
Publicado 2023

DIPG-63. LOSS OF THE H4 LYSINE METHYLTRANSFERASE KMT5B DRIVES INVASION / MIGRATION BY DEPLETING H3K27me3 AT LOCI OTHERWISE RETAINED IN H3K27M MUTANT DIPG CELLS

por Kessler, Ketty, Mackay, Alan, Molinari, Valeria, Tari, Haider, Burford, Anna, Sottoriva, Andrea, Vinci, Maria, Jones, Chris
Publicado 2020

Distinct Phenotypic Differences Associated with Differential Amplification of Receptor Tyrosine Kinase Genes at 4q12 in Glioblastoma

por Burford, Anna, Little, Suzanne E., Jury, Alexa, Popov, Sergey, Laxton, Ross, Doey, Lawrence, Al-Sarraj, Safa, Jürgensmeier, Juliane M., Jones, Chris
Publicado 2013

The ten-year evolutionary trajectory of a highly recurrent paediatric high grade neuroepithelial tumour with MN1:BEND2 fusion

por Burford, Anna, Mackay, Alan, Popov, Sergey, Vinci, Maria, Carvalho, Diana, Clarke, Matthew, Izquierdo, Elisa, Avery, Aimee, Jacques, Thomas S., Ingram, Wendy J., Moore, Andrew S., Frawley, Kieran, Hassall, Timothy E., Robertson, Thomas, Jones, Chris
Publicado 2018

HGG-42. Evolutionary selection of key oncogenic alterations in patient-derived models of paediatric diffuse high grade glioma (PDHGG) subtypesin vitro andin vivo

por Mackay, Alan, Temelso, Sara, Carvalho, Diana, Kessler, Ketty, Boult, Jessica, Izquierdo, Elisa, Pereira, Rita, Potente, Elisabet Fernandez, Burford, Anna, Molinari, Valeria, Bjerke, Lynn, Grabovska, Yura, Rogers, Rebecca, Crampsie, Shauna, Das, Molina, Robinson, Simon, Clarke, Matthew, Jones, Chris
Publicado 2022

DIPG-29. A CONNECT CONSORTIUM PRECLINICAL STUDY IDENTIFIES MEK INHIBITION AND RADIATION AS POTENTIAL COMBINATION PARTNERS FOR THE ALK2 INHIBITOR TP-0184 IN ACVR1-MUTANT DMG

por Rogers, Rebecca, Tsoli, Maria, Kumar, Shiva Senthil, Potente, Elisabet Fernandez, Biery, Matt, Grabovska, Yura, Mackay, Alan, Carvalho, Diana, Pereria, Rita, Burford, Anna, Sejdiu, Drenusha, Ruddle, Ruth, Gabel, Florian, Raynaud, Florence, Yadavilli, Sridevi, Mizoguchi, Sean, Subramaniam, Bavani, Kilburn, Lindsey, Hwang, Eugene, Nazarian, Javad, Vitanza, Nicholas, Ziegler, David, Drissi, Rachid, Jones, Chris
Publicado 2023

Inhibition of exosome biogenesis affects cell motility in heterogeneous sub-populations of paediatric-type diffuse high-grade gliomas

por Pericoli, Giulia, Galardi, Angela, Paolini, Alessandro, Petrilli, Lucia Lisa, Pepe, Gerardo, Palma, Alessandro, Colletti, Marta, Ferretti, Roberta, Giorda, Ezio, Levi Mortera, Stefano, Burford, Anna, Carai, Andrea, Mastronuzzi, Angela, Mackay, Alan, Putignani, Lorenza, Jones, Chris, Pascucci, Luisa, Peinado, Hector, Helmer-Citterich, Manuela, de Billy, Emmanuel, Masotti, Andrea, Locatelli, Franco, Di Giannatale, Angela, Vinci, Maria
Publicado 2023

MODL-20. A BIOBANK OF ~100 PATIENT-DERIVED MODELS REPRESENTING BIOLOGICAL HETEROGENEITY AND DISTINCT THERAPEUTIC DEPENDENCIES IN PAEDIATRIC HIGH GRADE GLIOMA AND DIPG

por Carvalho, Diana, Mackay, Alan, Temelso, Sara, Izquierdo, Elisa, Fernandez, Elisabet Potente, Rogers, Rebecca, Boult, Jessica, Salom, Janat Fazal, Simon, Natalie, Clarke, Matthew, Molinari, Valeria, Kessler, Ketty, Burford, Anna, Bjerke, Lynn, Fofana, Mariama, Hubank, Michael, Pears, Jane, Moore, Andrew, Carcaboso, Angel Montero, Marshall, Lynley, Carceller, Fernando, Robinson, Simon, Hargrave, Darren, Vinci, Maria, Jones, Chris
Publicado 2020

HGG-43. Abrogation of exosome biogenesis significantly affects cell motility in heterogenous sub-populations of paediatric-type diffuse high-grade glioma

por Pericoli, Giulia, Galardi, Angela, Petrilli, Lucia Lisa, Paolini, Alessandro, Mortera, Stefano Levi, Pepe, Gerardo, Palma, Alessandro, de Billy, Emmanuel, Ferretti, Roberta, Colletti, Marta, Giorda, Ezio, Burford, Anna, Mackay, Alan, Pascucci, Luisa, Peinado, Hector, Jones, Chris, Citterich, Manuela Helmer, Putignani, Lorenza, Carai, Andrea, Mastronuzzi, Angela, Masotti, Andrea, Locatelli, Franco, Giannatale, Angela Di, Vinci, Maria
Publicado 2022

Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial

por Mackay, Alan, Burford, Anna, Molinari, Valeria, Jones, David T.W., Izquierdo, Elisa, Brouwer-Visser, Jurriaan, Giangaspero, Felice, Haberler, Christine, Pietsch, Torsten, Jacques, Thomas S., Figarella-Branger, Dominique, Rodriguez, Daniel, Morgan, Paul S., Raman, Pichai, Waanders, Angela J., Resnick, Adam C., Massimino, Maura, Garrè, Maria Luisa, Smith, Helen, Capper, David, Pfister, Stefan M., Würdinger, Thomas, Tam, Rachel, Garcia, Josep, Thakur, Meghna Das, Vassal, Gilles, Grill, Jacques, Jaspan, Tim, Varlet, Pascale, Jones, Chris
Publicado 2018

HGG-17. SINGLE-CELL AND SPATIAL ANALYSES DECIPHER THE UNIQUE INVASIVE GROWTH PATTERN OF GLIOMATOSIS CEREBRI

por Crampsie, Shauna, Liu, Ilon, Petrilli, Lucia Lisa, Mackay, Alan, Spinozzi, Giulio, Grabovska, Yura, Hack, Olivia A, Kessler, Ketty, Temelso, Sara, Carvalho, Diana Martins, Burford, Anna, Sejdiu, Drenusha, Molinari, Valeria, Shaw, McKenzie L, Mire, Hafsa M, Pericoli, Giulia, Cerimele, Alfredo, Barry, Clémentine, Cocito, Carolina, Debily, Marie-Anne, Kergrohen, Thomas, Ajlil, Yassine, Beccaria, Kévin, Varlet, Pascale, Tauziède-Espariat, Arnault, Mastronuzzi, Angela, Carai, Andrea, Giovannoni, Isabella, Rossi, Sabrina, Miele, Evelina, Grill, Jacques, Jacques, Thomas S, Greenfield, Jeffery P, Castel, David, Vinci, Maria, Filbin, Mariella G, Jones, Chris
Publicado 2023

Functional diversity and co-operativity between subclonal populations of paediatric glioblastoma and diffuse intrinsic pontine glioma cells

por Vinci, Mara, Burford, Anna, Molinari, Valeria, Kessler, Ketty, Popov, Sergey, Clarke, Matthew, Taylor, Kathryn R, Pemberton, Helen, Lord, Christopher J, Gutteridge, Alice, Forshew, Tim, Carvalho, Diana, Marshall, Lynley V, Qin, Elizabeth Y, Ingram, Wendy J, Moore, Andrew S, Ng, Ho-Keung, Trabelsi, Saoussen, Brahim, Dorra H’mida-Ben, Entz-Werle, Natacha, Zacharoulis, Stergios, Vaidya, Sucheta, Mandeville, Henry C, Bridges, Leslie R, Martin, Andrew J, Al-Sarraj, Safa, Chandler, Christopher, Sunol, Mariona, Mora, Jaume, de Torres, Carmen, Cruz, Ofelia, Carcaboso, Angel M, Monje, Michelle, Mackay, Alan, Jones, Chris
Publicado 2018

Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma

por Mackay, Alan, Burford, Anna, Carvalho, Diana, Izquierdo, Elisa, Fazal-Salom, Janat, Taylor, Kathryn R., Bjerke, Lynn, Clarke, Matthew, Vinci, Mara, Nandhabalan, Meera, Temelso, Sara, Popov, Sergey, Molinari, Valeria, Raman, Pichai, Waanders, Angela J., Han, Harry J., Gupta, Saumya, Marshall, Lynley, Zacharoulis, Stergios, Vaidya, Sucheta, Mandeville, Henry C., Bridges, Leslie R., Martin, Andrew J., Al-Sarraj, Safa, Chandler, Christopher, Ng, Ho-Keung, Li, Xingang, Mu, Kun, Trabelsi, Saoussen, Brahim, Dorra H’mida-Ben, Kisljakov, Alexei N., Konovalov, Dmitry M., Moore, Andrew S., Carcaboso, Angel Montero, Sunol, Mariona, de Torres, Carmen, Cruz, Ofelia, Mora, Jaume, Shats, Ludmila I., Stavale, João N., Bidinotto, Lucas T., Reis, Rui M., Entz-Werle, Natacha, Farrell, Michael, Cryan, Jane, Crimmins, Darach, Caird, John, Pears, Jane, Monje, Michelle, Debily, Marie-Anne, Castel, David, Grill, Jacques, Hawkins, Cynthia, Nikbakht, Hamid, Jabado, Nada, Baker, Suzanne J., Pfister, Stefan M., Jones, David T.W., Fouladi, Maryam, von Bueren, André O., Baudis, Michael, Resnick, Adam, Jones, Chris
Publicado 2017