Beyond Just Peptide Antigens: The Complex World of Peptide-Based Cancer Vaccines

por Stephens, Alexander J., Burgess-Brown, Nicola A., Jiang, Shisong
Publicado 2021

High-throughput production of human proteins for crystallization: The SGC experience

por Savitsky, Pavel, Bray, James, Cooper, Christopher D.O., Marsden, Brian D., Mahajan, Pravin, Burgess-Brown, Nicola A., Gileadi, Opher
Publicado 2010

Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis

por Montgomery, Anna B, Kopec, Jolanta, Shrestha, Leela, Thezenas, Marie-Laetitia, Burgess-Brown, Nicola A, Fischer, Roman, Yue, Wyatt W, Venables, Patrick J
Publicado 2016

Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome

por Barr, Alastair J., Ugochukwu, Emilie, Lee, Wen Hwa, King, Oliver N.F., Filippakopoulos, Panagis, Alfano, Ivan, Savitsky, Pavel, Burgess-Brown, Nicola A., Müller, Susanne, Knapp, Stefan
Publicado 2009

Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching

por Philpott, Martin, Rogers, Catherine M, Yapp, Clarence, Wells, Chris, Lambert, Jean-Philippe, Strain-Damerell, Claire, Burgess-Brown, Nicola A, Gingras, Anne-Claude, Knapp, Stefan, Müller, Susanne
Publicado 2014

A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation

por Lucic, Bojana, Zhang, Ying, King, Oliver, Mendoza-Maldonado, Ramiro, Berti, Matteo, Niesen, Frank H., Burgess-Brown, Nicola A., Pike, Ashley C. W., Cooper, Christopher D. O., Gileadi, Opher, Vindigni, Alessandro
Publicado 2011

Identification, mapping and relative quantitation of SARS-CoV-2 Spike glycopeptides by Mass-Retention Time Fingerprinting

por Chalk, Rod, Greenland, William E. P., Moreira, Tiago, Coker, Jesse, Mukhopadhyay, Shubhashish M. M., Williams, Eleanor, Manning, Charlotte, Bohstedt, Tina, McCrorie, Rama, Fernandez-Cid, Alejandra, Burgess-Brown, Nicola A.
Publicado 2021

Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation

por Keates, Tracy, Cooper, Christopher D.O., Savitsky, Pavel, Allerston, Charles K., Phillips, Claire, Hammarström, Martin, Daga, Neha, Berridge, Georgina, Mahajan, Pravin, Burgess-Brown, Nicola A., Müller, Susanne, Gräslund, Susanne, Gileadi, Opher
Publicado 2012

Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor

por England, Katherine S., Tumber, Anthony, Krojer, Tobias, Scozzafava, Giuseppe, Ng, Stanley S., Daniel, Michelle, Szykowska, Aleksandra, Che, KaHing, von Delft, Frank, Burgess-Brown, Nicola A., Kawamura, Akane, Schofield, Christopher J., Brennan, Paul E.
Publicado 2014

FAS2FURIOUS: Moderate-Throughput Secreted Expression of Difficult Recombinant Proteins in Drosophila S2 Cells

por Coker, Jesse A., Katis, Vittorio L., Fairhead, Michael, Schwenzer, Anja, Clemmensen, Stine B., Frandsen, Bent U., de Jongh, Willem A., Gileadi, Opher, Burgess-Brown, Nicola A., Marsden, Brian D., Midwood, Kim S., Yue, Wyatt W.
Publicado 2022

Structure and activation mechanism of the human liver-type glutaminase GLS2

por Ferreira, Igor M., Quesñay, José Edwin N., Bastos, Alliny CS., Rodrigues, Camila T., Vollmar, Melanie, Krojer, Tobias, Strain-Damerell, Claire, Burgess-Brown, Nicola A., von Delft, Frank, Yue, Wyatt W., Dias, Sandra MG., Ambrosio, Andre LB.
Publicado 2021

The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery

por Bradley, Anthony R., Echalier, Aude, Fairhead, Michael, Strain-Damerell, Claire, Brennan, Paul, Bullock, Alex N., Burgess-Brown, Nicola A., Carpenter, Elisabeth P., Gileadi, Opher, Marsden, Brian D., Lee, Wen Hwa, Yue, Wyatt, Bountra, Chas, von Delft, Frank
Publicado 2017

Structural characterization of human urea transporters UT-A and UT-B and their inhibition

por Chi, Gamma, Dietz, Larissa, Tang, Haiping, Snee, Matthew, Scacioc, Andreea, Wang, Dong, Mckinley, Gavin, Mukhopadhyay, Shubhashish M. M., Pike, Ashley C. W., Chalk, Rod, Burgess-Brown, Nicola A., Timmermans, Jean-Pierre, van Putte, Wouter, Robinson, Carol V., Dürr, Katharina L.
Publicado 2023

Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain

por Szykowska, Aleksandra, Chen, Yu, Smith, Thomas B., Preger, Charlotta, Yang, Jingjing, Qian, Dongming, Mukhopadhyay, Shubhashish M., Wigren, Edvard, Neame, Stephen J., Gräslund, Susanne, Persson, Helena, Atkinson, Peter J., Di Daniel, Elena, Mead, Emma, Wang, John, Davis, John B., Burgess-Brown, Nicola A., Bullock, Alex N.
Publicado 2021

Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain

por Chi, Gamma, Liang, Qiansheng, Sridhar, Akshay, Cowgill, John B., Sader, Kasim, Radjainia, Mazdak, Qian, Pu, Castro-Hartmann, Pablo, Venkaya, Shayla, Singh, Nanki Kaur, McKinley, Gavin, Fernandez-Cid, Alejandra, Mukhopadhyay, Shubhashish M. M., Burgess-Brown, Nicola A., Delemotte, Lucie, Covarrubias, Manuel, Dürr, Katharina L.
Publicado 2022

The PHD and Chromo Domains Regulate the ATPase Activity of the Human Chromatin Remodeler CHD4

por Watson, Aleksandra A., Mahajan, Pravin, Mertens, Haydyn D.T., Deery, Michael J., Zhang, Wenchao, Pham, Peter, Du, Xiuxia, Bartke, Till, Zhang, Wei, Edlich, Christian, Berridge, Georgina, Chen, Yun, Burgess-Brown, Nicola A., Kouzarides, Tony, Wiechens, Nicola, Owen-Hughes, Tom, Svergun, Dmitri I., Gileadi, Opher, Laue, Ernest D.
Publicado 2012

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

por Tumber, Anthony, Nuzzi, Andrea, Hookway, Edward S., Hatch, Stephanie B., Velupillai, Srikannathasan, Johansson, Catrine, Kawamura, Akane, Savitsky, Pavel, Yapp, Clarence, Szykowska, Aleksandra, Wu, Na, Bountra, Chas, Strain-Damerell, Claire, Burgess-Brown, Nicola A., Ruda, Gian Filippo, Fedorov, Oleg, Munro, Shonagh, England, Katherine S., Nowak, Radoslaw P., Schofield, Christopher J., La Thangue, Nicholas B., Pawlyn, Charlotte, Davies, Faith, Morgan, Gareth, Athanasou, Nick, Müller, Susanne, Oppermann, Udo, Brennan, Paul E.
Publicado 2017

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K

por Bushell, Simon R., Pike, Ashley C. W., Falzone, Maria E., Rorsman, Nils J. G., Ta, Chau M., Corey, Robin A., Newport, Thomas D., Christianson, John C., Scofano, Lara F., Shintre, Chitra A., Tessitore, Annamaria, Chu, Amy, Wang, Qinrui, Shrestha, Leela, Mukhopadhyay, Shubhashish M. M., Love, James D., Burgess-Brown, Nicola A., Sitsapesan, Rebecca, Stansfeld, Phillip J., Huiskonen, Juha T., Tammaro, Paolo, Accardi, Alessio, Carpenter, Elisabeth P.
Publicado 2019

Phospho‐regulation, nucleotide binding and ion access control in potassium‐chloride cotransporters

por Chi, Gamma, Ebenhoch, Rebecca, Man, Henry, Tang, Haiping, Tremblay, Laurence E, Reggiano, Gabriella, Qiu, Xingyu, Bohstedt, Tina, Liko, Idlir, Almeida, Fernando G, Garneau, Alexandre P, Wang, Dong, McKinley, Gavin, Moreau, Christophe P, Bountra, Kiran D, Abrusci, Patrizia, Mukhopadhyay, Shubhashish M M, Fernandez‐Cid, Alejandra, Slimani, Samira, Lavoie, Julie L, Burgess‐Brown, Nicola A, Tehan, Ben, DiMaio, Frank, Jazayeri, Ali, Isenring, Paul, Robinson, Carol V, Dürr, Katharina L
Publicado 2021

Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design

por Dong, Yin Yao, Wang, Hua, Pike, Ashley C.W., Cochrane, Stephen A., Hamedzadeh, Sadra, Wyszyński, Filip J., Bushell, Simon R., Royer, Sylvain F., Widdick, David A., Sajid, Andaleeb, Boshoff, Helena I., Park, Yumi, Lucas, Ricardo, Liu, Wei-Min, Lee, Seung Seo, Machida, Takuya, Minall, Leanne, Mehmood, Shahid, Belaya, Katsiaryna, Liu, Wei-Wei, Chu, Amy, Shrestha, Leela, Mukhopadhyay, Shubhashish M.M., Strain-Damerell, Claire, Chalk, Rod, Burgess-Brown, Nicola A., Bibb, Mervyn J., Barry III, Clifton E., Robinson, Carol V., Beeson, David, Davis, Benjamin G., Carpenter, Elisabeth P.
Publicado 2018