Application of Pharmacokinetic-Pharmacodynamic Modeling to Inform Translation of In Vitro NaV1.7 Inhibition to In Vivo Pharmacological Response in Non-human Primate

por Ballard, Jeanine E., Pall, Parul, Vardigan, Joshua, Zhao, Fuqiang, Holahan, Marie A., Kraus, Richard, Li, Yuxing, Henze, Darrell, Houghton, Andrea, Burgey, Christopher S., Gibson, Christopher
Publicado 2020

Translational Pharmacokinetic–Pharmacodynamic Modeling of NaV1.7 Inhibitor MK-2075 to Inform Human Efficacious Dose

por Ballard, Jeanine E., Pall, Parul S., Vardigan, Joshua, Zhao, Fuqiang, Holahan, Marie A., Zhou, Xiaoping, Jochnowitz, Nina, Kraus, Richard L., Klein, Rebecca M., Henze, Darrell A., Houghton, Andrea K., Burgey, Christopher S., Gibson, Christopher, Struyk, Arie
Publicado 2021

Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve

por Klein, Rebecca M., Layton, Mark E., Regan, Hillary, Regan, Christopher P., Li, Yuxing, Filzen, Tracey, Cato, Matt, Clements, Michelle K., Wang, Jixin, Sanoja, Raul, Greshock, Thomas J., Roecker, Anthony J., Pero, Joseph E., Kim, Ron, Burgey, Christopher, John, Christopher T., Wang, Ying-Hong, Bhandari, Neetesh, Struyk, Arie, Kraus, Richard L., Henze, Darrell A., Houghton, Andrea K.
Publicado 2022