Human topoisomerase IIα uses a two-metal-ion mechanism for DNA cleavage

por Deweese, Joseph E., Burgin, Alex B., Osheroff, Neil
Publicado 2008

A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases

por Schmidt, Bryan H., Burgin, Alex B., Deweese, Joseph E., Osheroff, Neil, Berger, James M.
Publicado 2010

Artificial Neural Networks Trained to Detect Viral and Phage Structural Proteins

por Seguritan, Victor, Alves, Nelson, Arnoult, Michael, Raymond, Amy, Lorimer, Don, Burgin, Alex B., Salamon, Peter, Segall, Anca M.
Publicado 2012

Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV

por Pitts, Steven L., Liou, Grace F., Mitchenall, Lesley A., Burgin, Alex B., Maxwell, Anthony, Neuman, Keir C., Osheroff, Neil
Publicado 2011

Structure and function of a cyanophage-encoded peptide deformylase

por Frank, Jeremy A, Lorimer, Don, Youle, Merry, Witte, Pam, Craig, Tim, Abendroth, Jan, Rohwer, Forest, Edwards, Robert A, Segall, Anca M, Burgin, Alex B
Publicado 2013

Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography

por Davies, Douglas R., Mamat, Bjorn, Magnusson, Olafur T., Christensen, Jeff, Haraldsson, Magnus H., Mishra, Rama, Pease, Brian, Hansen, Erik, Singh, Jasbir, Zembower, David, Kim, Hidong, Kiselyov, Alex S., Burgin, Alex B., Gurney, Mark E., Stewart, Lance J.
Publicado 2009

Corrections to Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography

por Davies, Douglas R., Mamat, Bjorn, Magnusson, Olafur T., Christensen, Jeff, Haraldsson, Magnus H., Mishra, Rama, Pease, Brian, Hansen, Erik, Singh, Jasbir, Zembower, David, Kim, Hidong, Kiselyov, Alex S., Burgin, Alex B., Gurney, Mark E., Stewart, Lance J.
Publicado 2010

Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases

por Park, Sung-Jun, Ahmad, Faiyaz, Philp, Andrew, Baar, Keith, Williams, Tishan, Luo, Haibin, Ke, Hengming, Rehmann, Holger, Taussig, Ronald, Brown, Alexandra L, Kim, Myung K, Beaven, Michael A, Burgin, Alex B, Manganiello, Vincent, Chung, Jay H
Publicado 2012

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

por Sanchez, Savannah E., Cuevas, Daniel A., Rostron, Jason E., Liang, Tiffany Y., Pivaroff, Cullen G., Haynes, Matthew R., Nulton, Jim, Felts, Ben, Bailey, Barbara A., Salamon, Peter, Edwards, Robert A., Burgin, Alex B., Segall, Anca M., Rohwer, Forest
Publicado 2015

A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1

por Clifton, Matthew C., Dranow, David M., Leed, Alison, Fulroth, Ben, Fairman, James W., Abendroth, Jan, Atkins, Kateri A., Wallace, Ellen, Fan, Dazhong, Xu, Guoping, Ni, Z. J., Daniels, Doug, Van Drie, John, Wei, Guo, Burgin, Alex B., Golub, Todd R., Hubbard, Brian K., Serrano-Wu, Michael H.
Publicado 2015

Identification of cancer cytotoxic modulators of PDE3A by predictive chemogenomics

por de Waal, Luc, Lewis, Timothy A., Rees, Matthew G., Tsherniak, Aviad, Wu, Xiaoyun, Choi, Peter S., Gechijian, Lara, Hartigan, Christina, Faloon, Patrick W., Hickey, Mark J., Tolliday, Nicola, Carr, Steven A., Clemons, Paul A., Munoz, Benito, Wagner, Bridget K., Shamji, Alykhan F., Koehler, Angela N., Schenone, Monica, Burgin, Alex B., Schreiber, Stuart L., Greulich, Heidi, Meyerson, Matthew
Publicado 2015