Engineering mutually orthogonal PylRS/tRNA pairs for dual encoding of functional histidine analogues

por Taylor, Christopher J., Hardy, Florence J., Burke, Ashleigh J., Bednar, Riley M., Mehl, Ryan A., Green, Anthony P., Lovelock, Sarah L.
Publicado 2023

Engineering an Efficient and Enantioselective Enzyme for the Morita-Baylis-Hillman Reaction

por Crawshaw, Rebecca, Crossley, Amy E., Johannissen, Linus, Burke, Ashleigh J., Hay, Sam, Levy, Colin, Baker, David, Lovelock, Sarah L., Green, Anthony P.
Publicado 2022

Multicomponent Synthesis of the SARS-CoV-2 Main Protease Inhibitor Nirmatrelvir

por Preschel, H. Daniel, Otte, Ruben T., Zhuo, Ying, Ruscoe, Rebecca E., Burke, Ashleigh J., Kellerhals, Rachel, Horst, Brendan, Hennig, Sven, Janssen, Elwin, Green, Anthony P., Turner, Nicholas J., Ruijter, Eelco
Publicado 2023

An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir

por Burke, Ashleigh J., Birmingham, William R., Zhuo, Ying, Thorpe, Thomas W., Zucoloto da Costa, Bruna, Crawshaw, Rebecca, Rowles, Ian, Finnigan, James D., Young, Carl, Holgate, Gregory M., Muldowney, Mark P., Charnock, Simon J., Lovelock, Sarah L., Turner, Nicholas J., Green, Anthony P.
Publicado 2022