Molecular insight into the autoinhibition of a master regulator of lipid signalling in human disease

por Burke, John E.
Publicado 2020

Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS)

por Burke, John E., Williams, Roger L.
Publicado 2013

Molecular Mechanisms of Human Disease Mediated by Oncogenic and Primary Immunodeficiency Mutations in Class IA Phosphoinositide 3-Kinases

por Dornan, Gillian L., Burke, John E.
Publicado 2018

Allosteric activation of PI3Kα by oncogenic mutations

por Burke, John E., Perisic, Olga, Williams, Roger L.
Publicado 2013

The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity

por Masson, Glenn R., Perisic, Olga, Burke, John E., Williams, Roger L.
Publicado 2016

Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation

por Levina, Aleksandra, Fleming, Kaelin D., Burke, John E., Leonard, Thomas A.
Publicado 2022

Beyond PI3Ks: targeting phosphoinositide kinases in disease

por Burke, John E., Triscott, Joanna, Emerling, Brooke M., Hammond, Gerald R. V.
Publicado 2022

In vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate

por Pokorny, Daniel, Truebestein, Linda, Fleming, Kaelin D., Burke, John E., Leonard, Thomas A.
Publicado 2021

Dynamics of the Phosphoinositide 3-Kinase p110δ Interaction with p85α and Membranes Reveals Aspects of Regulation Distinct from p110α

por Burke, John E., Vadas, Oscar, Berndt, Alex, Finegan, Tara, Perisic, Olga, Williams, Roger L.
Publicado 2011

Conformational sampling of membranes by Akt controls its activation and inactivation

por Lučić, Iva, Rathinaswamy, Manoj K., Truebestein, Linda, Hamelin, David J., Burke, John E., Leonard, Thomas A.
Publicado 2018

Publisher Correction: Crystal structure of a lipin/Pah phosphatidic acid phosphatase

por Khayyo, Valerie I., Hoffmann, Reece M., Wang, Huan, Bell, Justin A., Burke, John E., Reue, Karen, Airola, Michael V.
Publicado 2020

Crystal structure of an archaeal CorB magnesium transporter

por Chen, Yu Seby, Kozlov, Guennadi, Moeller, Brandon E., Rohaim, Ahmed, Fakih, Rayan, Roux, Benoît, Burke, John E., Gehring, Kalle
Publicado 2021

Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus

por Jenkins, Meredith L., Ranga-Prasad, Harish, Parson, Matthew A. H., Harris, Noah J., Rathinaswamy, Manoj K., Burke, John E.
Publicado 2023

The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site

por Clarke, Jonathan H., Giudici, Maria-Luisa, Burke, John E., Williams, Roger L., Maloney, David J., Marugan, Juan, Irvine, Robin F.
Publicado 2015

Crystal structure of a lipin/Pah phosphatidic acid phosphatase

por Khayyo, Valerie I., Hoffmann, Reece M., Wang, Huan, Bell, Justin A., Burke, John E., Reue, Karen, Airola, Michael V. V.
Publicado 2020

PKD autoinhibition in trans regulates activation loop autophosphorylation in cis

por Reinhardt, Ronja, Hirzel, Kai, Link, Gisela, Eisler, Stephan A., Hägele, Tanja, Parson, Matthew A. H., Burke, John E., Hausser, Angelika, Leonard, Thomas A.
Publicado 2023

Structure of autoinhibited Akt1 reveals mechanism of PIP(3)-mediated activation

por Truebestein, Linda, Hornegger, Harald, Anrather, Dorothea, Hartl, Markus, Fleming, Kaelin D., Stariha, Jordan T. B., Pardon, Els, Steyaert, Jan, Burke, John E., Leonard, Thomas A.
Publicado 2021

Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes

por Siraliev-Perez, Edhriz, Stariha, Jordan TB, Hoffmann, Reece M, Temple, Brenda RS, Zhang, Qisheng, Hajicek, Nicole, Jenkins, Meredith L, Burke, John E, Sondek, John
Publicado 2022

Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11

por Fowler, Melissa L., McPhail, Jacob A., Jenkins, Meredith L., Masson, Glenn R., Rutaganira, Florentine U., Shokat, Kevan M., Williams, Roger L., Burke, John E.
Publicado 2016

Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors

por Rathinaswamy, Manoj K, Gaieb, Zied, Fleming, Kaelin D, Borsari, Chiara, Harris, Noah J, Moeller, Brandon E, Wymann, Matthias P, Amaro, Rommie E, Burke, John E
Publicado 2021