Development of Grb2 SH2 Domain Signaling Antagonists: A Potential New Class of Antiproliferative Agents

por Burke , Terrence R.
Publicado 2006

Synthetic Approaches to a Key Pyridone-carboxylic Acid Precursor Common to the HIV-1 Integrase Strand Transfer Inhibitors Dolutegravir, Bictegravir, and Cabotegravir

por Mahajan, Pankaj S., Burke, Terrence R.
Publicado 2023

Application of Post Solid-Phase Oxime Ligation to Fine-Tune Peptide–Protein Interactions

por Zhao, Xue Zhi, Liu, Fa, Burke, Terrence R.
Publicado 2020

Development of Highly Selective 1,2,3-Triazole-containing Peptidic Polo-like Kinase 1 Polo-box Domain-binding Inhibitors

por Zhao, Xue Zhi, Tsuji, Kohei, Hymel, David, Burke, Terrence R.
Publicado 2019

Efficacies of Cabotegravir and Bictegravir against drug-resistant HIV-1 integrase mutants

por Smith, Steven J., Zhao, Xue Zhi, Burke, Terrence R., Hughes, Stephen H.
Publicado 2018

Conventional and Chemically Programmed Asymmetric Bispecific Antibodies Targeting Folate Receptor 1

por Qi, Junpeng, Hymel, David, Nelson, Christopher G., Burke, Terrence R., Rader, Christoph
Publicado 2019

An NMR strategy for fragment-based ligand screening utilizing a paramagnetic lanthanide probe

por Saio, Tomohide, Ogura, Kenji, Shimizu, Kazumi, Yokochi, Masashi, Burke, Terrence R., Inagaki, Fuyuhiko
Publicado 2011

Development of ultra-high affinity bivalent ligands targeting the polo-like kinase 1

por Tsuji, Kohei, Hymel, David, Ma, Buyong, Tamamura, Hirokazu, Nussinov, Ruth, Burke, Terrence R.
Publicado 2022

A Practical Approach to Bicyclic Carbamoyl Pyridones with Application to the Synthesis of HIV-1 Integrase Strand Transfer Inhibitors

por Mahajan, Pankaj S., Smith, Steven J., Hughes, Stephen H., Zhao, Xuezhi, Burke, Terrence R.
Publicado 2023

Examination of aminophenol-containing compounds designed as antiproliferative agents and potential atypical retinoids

por Chingle, Ramesh M., Imai, Masahiko, Altman, Sarah, Saito, Daisuke, Takahashi, Noriko, Burke, Terrence R.
Publicado 2023

Synergistic anti-leukemic activity of imatinib in combination with a small molecule Grb2 SH2 domain binding antagonist

por Zhang, Manchao, Luo, Zhenghua, Liu, Hongpeng, Croce, Carlo M., Burke, Terrence R., Bottaro, Donald P.
Publicado 2013

Comparison of metal-dependent catalysis by HIV-1 and ASV integrase proteins using a new and rapid, moderate throughput assay for joining activity in solution

por Andrake, Mark D, Ramcharan, Joseph, Merkel, George, Zhao, Xue Zhi, Burke, Terrence R, Skalka, Anna Marie
Publicado 2009

Integrase Strand Transfer Inhibitors Are Effective Anti-HIV Drugs

por Smith, Steven J., Zhao, Xue Zhi, Passos, Dario Oliveira, Lyumkis, Dmitry, Burke, Terrence R., Hughes, Stephen H.
Publicado 2021

Phosphonic acid-containing inhibitors of tyrosyl-DNA phosphodiesterase 1

por Zhao, Xue Zhi, Wang, Wenjie, Lountos, George T., Tropea, Joseph E., Needle, Danielle, Pommier, Yves, Burke, Terrence R.
Publicado 2022

INSTIs and NNRTIs Potently Inhibit HIV-1 Polypurine Tract Mutants in a Single Round Infection Assay

por Smith, Steven J., Ferris, Andrea, Zhao, Xuezhi, Pauly, Gary, Schneider, Joel P., Burke, Terrence R., Hughes, Stephen H.
Publicado 2021

Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification

por Zhao, Xue Zhi, Wang, Wenjie, Lountos, George T., Kiselev, Evgeny, Tropea, Joseph E., Needle, Danielle, Pommier, Yves, Burke, Terrence R.
Publicado 2023

Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain – binding peptide macro...

por Hymel, David, Tsuji, Kohei, Grant, Robert A., Chingle, Ramesh M., Kunciw, Dominique L., Yaffe, Michael B., Burke, Terrence R.
Publicado 2021

Bicyclic 1-Hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-Containing HIV-1 Integrase Inhibitors Having High Antiviral Potency against Cells Harboring Raltegravir-Resistant Integra...

por Zhao, Xue Zhi, Smith, Steven J., Métifiot, Mathieu, Johnson, Barry C., Marchand, Christophe, Pommier, Yves, Hughes, Stephen H., Burke, Terrence R.
Publicado 2014

Targeting the Fcμ-receptor in chronic lymphocytic leukemia with a novel IgM-derived antibody-drug conjugate

por Skarzynski, Martin, Vire, Bérengère, Thomas, Joshua D, Nelson, Christopher G, David, Alexandre, Aue, Georg, Burke, Terrence R, Rader, Christoph, Wiestner, Adrian
Publicado 2013

4-Amino-1-hydroxy-2-oxo-1,8-naphthyridine-Containing Compounds Having High Potency against Raltegravir-Resistant Integrase Mutants of HIV-1

por Zhao, Xue Zhi, Smith, Steven J., Métifiot, Mathieu, Marchand, Christophe, Boyer, Paul L., Pommier, Yves, Hughes, Stephen H., Burke, Terrence R.
Publicado 2014