Chorea-related mutations in PDE10A result in aberrant compartmentalization and functionality of the enzyme

por Tejeda, Gonzalo S., Whiteley, Ellanor L., Deeb, Tarek Z., Bürli, Roland W., Moss, Stephen J., Sheridan, Eamonn, Brandon, Nicholas J., Baillie, George S.
Publicado 2020

A comparative study of fragment screening methods on the p38α kinase: new methods, new insights

por Pollack, Scott J., Beyer, Kim S., Lock, Christopher, Müller, Ilka, Sheppard, David, Lipkin, Mike, Hardick, David, Blurton, Peter, Leonard, Philip M., Hubbard, Paul A., Todd, Daniel, Richardson, Christine M., Ahrens, Thomas, Baader, Manuel, Hafenbradl, Doris O., Hilyard, Kate, Bürli, Roland W.
Publicado 2011

Oral Administration of the Pimelic Diphenylamide HDAC Inhibitor HDACi 4b Is Unsuitable for Chronic Inhibition of HDAC Activity in the CNS In Vivo

por Beconi, Maria, Aziz, Omar, Matthews, Kim, Moumné, Lara, O’Connell, Catherine, Yates, Dawn, Clifton, Steven, Pett, Hannah, Vann, Julie, Crowley, Lynsey, Haughan, Alan F., Smith, Donna L., Woodman, Ben, Bates, Gillian P., Brookfield, Fred, Bürli, Roland W., McAllister, George, Dominguez, Celia, Munoz-Sanjuan, Ignacio, Beaumont, Vahri
Publicado 2012

Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance

por Wrobel, Lidia, Hill, Sandra M., Djajadikerta, Alvin, Fernandez-Estevez, Marian, Karabiyik, Cansu, Ashkenazi, Avraham, Barratt, Victoria J., Stamatakou, Eleanna, Gunnarsson, Anders, Rasmusson, Timothy, Miele, Eric W., Beaton, Nigel, Bruderer, Roland, Feng, Yuehan, Reiter, Lukas, Castaldi, M. Paola, Jarvis, Rebecca, Tan, Keith, Bürli, Roland W., Rubinsztein, David C.
Publicado 2022

Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR(7) Allosteric Agonist

por Dickson, Louise, Teall, Martin, Chevalier, Elodie, Cheung, Toni, Liwicki, Gemma M., Mack, Stephen, Stephenson, Anne, White, Kathryn, Fosbeary, Richard, Harrison, David C., Brice, Nicola L., Doyle, Kevin, Ciccocioppo, Roberto, Wu, Chaobo, Almond, Sarah, Patel, Toshal R., Mitchell, Philip, Barnes, Matt, Ayscough, Andrew P., Dawson, Lee A., Carlton, Mark, Bürli, Roland W.
Publicado 2023

A small molecule mitigates hearing loss in a mouse model of Usher syndrome III

por Alagramam, Kumar N., Gopal, Suhasini R., Geng, Ruishuang, Chen, Daniel H.-C., Nemet, Ina, Lee, Richard, Tian, Guilian, Miyagi, Masaru, Malagu, Karine F., Lock, Christopher J., Esmieu, William R. K., Owens, Andrew P., Lindsay, Nicola A., Ouwehand, Krista, Albertus, Faywell, Fischer, David F., Bürli, Roland W., MacLeod, Angus M., Harte, William E., Palczewski, Krzysztof, Imanishi, Yoshikazu
Publicado 2016

Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice

por Jarvis, Rebecca, Josephine Ng, Shu Fun, Nathanson, Anna J., Cardarelli, Ross A., Abiraman, Krithika, Wade, Fergus, Evans-Strong, Aidan, Fernandez-Campa, Marina P., Deeb, Tarek Z., Smalley, Joshua L., Jamier, Tanguy, Gurrell, Ian K., McWilliams, Lisa, Kawatkar, Aarti, Conway, Leslie C., Wang, Qi, Burli, Roland W., Brandon, Nicholas J., Chessell, Iain P., Goldman, Aaron J., Maguire, Jamie L., Moss, Stephen J.
Publicado 2023

Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates

por Micali, Nicola, Kim, Suel-Kee, Diaz-Bustamante, Marcelo, Stein-O’Brien, Genevieve, Seo, Seungmae, Shin, Joo-Heon, Rash, Brian G., Ma, Shaojie, Wang, Yanhong, Olivares, Nicolas A., Arellano, Jon I., Maynard, Kristen R., Fertig, Elana J., Cross, Alan J., Bürli, Roland W., Brandon, Nicholas J., Weinberger, Daniel R., Chenoweth, Joshua G., Hoeppner, Daniel J., Sestan, Nenad, Rakic, Pasko, Colantuoni, Carlo, McKay, Ronald D.
Publicado 2020

Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome

por Ossola, Bernardino, Rifat, Ali, Rowland, Anna, Hunter, Helen, Drinkall, Samuel, Bender, Clare, Hamlischer, Mayida, Teall, Martin, Burley, Russell, Barker, Daneil F., Cadwalladr, David, Dickson, Louise, Lawrence, Jason M.K., Harvey, Jenna R.M., Lizio, Marina, Xu, Xiao, Kavanagh, Edel, Cheung, Toni, Sheardown, Steve, Lawrence, Catherine B., Harte, Michael, Brough, David, Madry, Christian, Matthews, Kim, Doyle, Kevin, Page, Keith, Powell, Justin, Brice, Nicola L., Bürli, Roland W., Carlton, Mark B., Dawson, Lee A.
Publicado 2023

Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs

por Burke, Emily E., Chenoweth, Joshua G., Shin, Joo Heon, Collado-Torres, Leonardo, Kim, Suel-Kee, Micali, Nicola, Wang, Yanhong, Colantuoni, Carlo, Straub, Richard E., Hoeppner, Daniel J., Chen, Huei-Ying, Sellers, Alana, Shibbani, Kamel, Hamersky, Gregory R., Diaz Bustamante, Marcelo, Phan, BaDoi N., Ulrich, William S., Valencia, Cristian, Jaishankar, Amritha, Price, Amanda J., Rajpurohit, Anandita, Semick, Stephen A., Bürli, Roland W., Barrow, James C., Hiler, Daniel J., Page, Stephanie C., Martinowich, Keri, Hyde, Thomas M., Kleinman, Joel E., Berman, Karen F., Apud, Jose A., Cross, Alan J., Brandon, Nicholas J., Weinberger, Daniel R., Maher, Brady J., McKay, Ronald D. G., Jaffe, Andrew E.
Publicado 2020