Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden

por Abubaker, Khalid, Luwor, Rodney B, Zhu, Hongjian, McNally, Orla, Quinn, Michael A, Burns, Christopher J, Thompson, Erik W, Findlay, Jock K, Ahmed, Nuzhat
Publicado 2014

BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells

por Baker, Emma K, Taylor, Scott, Gupte, Ankita, Sharp, Phillip P, Walia, Mannu, Walsh, Nicole C, Zannettino, Andrew CW, Chalk, Alistair M, Burns, Christopher J, Walkley, Carl R
Publicado 2015

HSP90 Inhibition Suppresses Lipopolysaccharide-Induced Lung Inflammation In Vivo

por Lilja, Andrew, Weeden, Clare E., McArthur, Kate, Nguyen, Thao, Donald, Alastair, Wong, Zi Xin, Dousha, Lovisa, Bozinovski, Steve, Vlahos, Ross, Burns, Christopher J., Asselin-Labat, Marie-Liesse, Anderson, Gary P.
Publicado 2015

Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia

por McArthur, Kate, D’Cruz, Akshay A., Segal, David, Lackovic, Kurt, Wilks, Andrew F., O’Donnell, Joanne A., Nowell, Cameron J., Gerlic, Motti, Huang, David C.S., Burns, Christopher J., Croker, Ben A.
Publicado 2017

A constricted opening in Kir channels does not impede potassium conduction

por Black, Katrina A., He, Sitong, Jin, Ruitao, Miller, David M., Bolla, Jani R., Clarke, Oliver B., Johnson, Paul, Windley, Monique, Burns, Christopher J., Hill, Adam P., Laver, Derek, Robinson, Carol V., Smith, Brian J., Gulbis, Jacqueline M.
Publicado 2020

Microbiological Characterization of VNRX-5236, a Broad-Spectrum β-Lactamase Inhibitor for Rescue of the Orally Bioavailable Cephalosporin Ceftibuten as a Carbapenem-Sparing Agent a...

por Chatwin, Cassandra L., Hamrick, Jodie C., Trout, Robert E. L., Myers, Cullen L., Cusick, Susan M., Weiss, William J., Pulse, Mark E., Xerri, Luigi, Burns, Christopher J., Moeck, Gregory, Daigle, Denis M., John, Kaitlyn, Uehara, Tsuyoshi, Pevear, Daniel C.
Publicado 2021

Discovery of VNRX-7145 (VNRX-5236 Etzadroxil): An Orally Bioavailable β-Lactamase Inhibitor for Enterobacterales Expressing Ambler Class A, C, and D Enzymes

por Trout, Robert E., Zulli, Allison, Mesaros, Eugen, Jackson, Randy W., Boyd, Steven, Liu, Bin, Hamrick, Jodie, Daigle, Denis, Chatwin, Cassandra L., John, Kaitlyn, McLaughlin, Lisa, Cusick, Susan M., Weiss, William J., Pulse, Mark E., Pevear, Daniel C., Moeck, Greg, Xerri, Luigi, Burns, Christopher J.
Publicado 2021

Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections

por Liu, Bin, Trout, Robert E. Lee, Chu, Guo-Hua, McGarry, Daniel, Jackson, Randy W., Hamrick, Jodie C., Daigle, Denis M., Cusick, Susan M., Pozzi, Cecilia, De Luca, Filomena, Benvenuti, Manuela, Mangani, Stefano, Docquier, Jean-Denis, Weiss, William J., Pevear, Daniel C., Xerri, Luigi, Burns, Christopher J.
Publicado 2019

VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa

por Hamrick, Jodie C., Docquier, Jean-Denis, Uehara, Tsuyoshi, Myers, Cullen L., Six, David A., Chatwin, Cassandra L., John, Kaitlyn J., Vernacchio, Salvador F., Cusick, Susan M., Trout, Robert E. L., Pozzi, Cecilia, De Luca, Filomena, Benvenuti, Manuela, Mangani, Stefano, Liu, Bin, Jackson, Randy W., Moeck, Greg, Xerri, Luigi, Burns, Christopher J., Pevear, Daniel C., Daigle, Denis M.
Publicado 2020