Synthesis of an Oxathiolane Drug Substance Intermediate Guided by Constraint-Driven Innovation

por Kashinath, K., Snead, David R., Burns, Justina M., Stringham, Rodger W., Gupton, B. Frank, McQuade, D. Tyler
Publicado 2020

An Economical Route to Lamivudine Featuring a Novel Strategy for Stereospecific Assembly

por Snead, David R., McQuade, D. Tyler, Ahmad, Saeed, Krack, Rudy, Stringham, Rodger W., Burns, Justina M., Abdiaj, Irini, Gopalsamuthiram, Vijayagopal, Nelson, Ryan C., Gupton, B. Frank
Publicado 2020

Expanding Access to Remdesivir via an Improved Pyrrolotriazine Synthesis: Supply Centered Synthesis

por Paymode, Dinesh J., Cardoso, Flavio S. P., Agrawal, Toolika, Tomlin, John W., Cook, Daniel W., Burns, Justina M., Stringham, Rodger W., Sieber, Joshua D., Gupton, B. Frank, Snead, David R.
Publicado 2020

Toward a Practical, Nonenzymatic Process for Investigational COVID-19 Antiviral Molnupiravir from Cytidine: Supply-Centered Synthesis

por Gopalsamuthiram, Vijayagopal, Kadam, Appasaheb L., Noble, Jeffrey K., Snead, David R., Williams, Corshai, Jamison, Timothy F., Senanayake, Chris, Yadaw, Ajay K., Roy, Sarabindu, Sirasani, Gopal, Gupton, B. Frank, Burns, Justina, Cook, Daniel W., Stringham, Rodger W., Ahmad, Saeed, Krack, Rudy
Publicado 2021

Practical and Scalable Two-Step Process for 6-(2-Fluoro-4-nitrophenyl)-2-oxa-6-azaspiro[3.3]heptane: A Key Intermediate of the Potent Antibiotic Drug Candidate TBI-223

por Cardoso, Flavio S.P., Kadam, Appasaheb L., Nelson, Ryan C., Tomlin, John W., Dahal, Dipendra, Kuehner, Christopher S., Gudvangen, Gard, Arduengo, Anthony J., Burns, Justina M., Aleshire, Sarah L., Snead, David R., Qu, Fengrui, Belmore, Ken, Ahmad, Saeed, Agrawal, Toolika, Sieber, Joshua D., Donsbach, Kai Oliver
Publicado 2023

Development of a Practical Synthesis of the 8-FDC Fragment of OPC-167832

por Gopalsamuthiram, Vijayagopal, Ho, Dang Binh, Peck, Cheryl L., Natarajan, Vasudevan, Agrawal, Toolika, Burns, Justina M., Bachert, John, Cook, Daniel W., Stringham, Rodger W., Nelson, Ryan, Ahmad, Saeed, Gupton, B. Frank, Snead, David R., McQuade, D. Tyler, Vaidyanathan, Rajappa, Donsbach, Kai, Sieber, Joshua D.
Publicado 2022