APC/C(Cdh1)-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage

por Cotto-Rios, Xiomaris M., Jones, Mathew J.K., Busino, Luca, Pagano, Michele, Huang, Tony T.
Publicado 2011

SCF(Fbxl3) Ubiquitin Ligase Targets Cryptochromes at Their Cofactor Pocket

por Xing, Weiman, Busino, Luca, Hinds, Thomas R., Marionni, Samuel T., Saifee, Nabiha H., Bush, Matthew F., Pagano, Michele, Zheng, Ning
Publicado 2013

SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination

por Guan, Yongjuan, Lin, Huijuan, Leu, N Adrian, Ruthel, Gordon, Fuchs, Serge Y, Busino, Luca, Luo, Mengcheng, Wang, P Jeremy
Publicado 2022

PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading

por Rona, Gergely, Roberti, Domenico, Yin, Yandong, Pagan, Julia K, Homer, Harrison, Sassani, Elizabeth, Zeke, Andras, Busino, Luca, Rothenberg, Eli, Pagano, Michele
Publicado 2018

Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor Roquin2

por Choi, Jaewoo, Lee, Kyutae, Ingvarsdottir, Kristin, Bonasio, Roberto, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Tadros, Saber, Green, Michael R., Busino, Luca
Publicado 2018

MEDB-62. Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation

por Chen, Zhuoyao, Ioris, Rafael, Richardson, Stacey, Van Ess, Ava, Vendrell, Iolanda, Kessler, Benedikt, Buffa, Francesca, Busino, Luca, Clifford, Steven, Bullock, Alex, D'Angiolella, Vincenzo
Publicado 2022

KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis

por Lin-Shiao, Enrique, Lan, Yemin, Coradin, Mariel, Anderson, Amy, Donahue, Greg, Simpson, Cory L., Sen, Payel, Saffie, Rizwan, Busino, Luca, Garcia, Benjamin A., Berger, Shelley L., Capell, Brian C.
Publicado 2018

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation

por Chen, Zhuoyao, Ioris, Rafael M., Richardson, Stacey, Van Ess, Ava N., Vendrell, Iolanda, Kessler, Benedikt M., Buffa, Francesca M., Busino, Luca, Clifford, Steven C., Bullock, Alex N., D’Angiolella, Vincenzo
Publicado 2022

RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation

por Zhou, Nan, Gutierrez-Uzquiza, Alvaro, Zheng, Xiang Yu, Chang, Renxu, Vogl, Dan T., Garfall, Alfred L., Bernabei, Luca, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Illendula, Anuradha, Bushweller, John H., Busino, Luca
Publicado 2019

p53 restoration in small cell lung cancer identifies a latent cyclophilin-dependent necrosis mechanism

por Acosta, Jonuelle, Li, Qinglan, Freeburg, Nelson F., Murali, Nivitha, Indeglia, Alexandra, Grothusen, Grant P., Cicchini, Michelle, Mai, Hung, Gladstein, Amy C., Adler, Keren M., Doerig, Katherine R., Li, Jinyang, Ruiz-Torres, Miguel, Manning, Kimberly L., Stanger, Ben Z., Busino, Luca, Murphy, Maureen, Wan, Liling, Feldser, David M.
Publicado 2023

ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP

por Bufalieri, Francesca, Infante, Paola, Bernardi, Flavia, Caimano, Miriam, Romania, Paolo, Moretti, Marta, Lospinoso Severini, Ludovica, Talbot, Julie, Melaiu, Ombretta, Tanori, Mirella, Di Magno, Laura, Bellavia, Diana, Capalbo, Carlo, Puget, Stéphanie, De Smaele, Enrico, Canettieri, Gianluca, Guardavaccaro, Daniele, Busino, Luca, Peschiaroli, Angelo, Pazzaglia, Simonetta, Giannini, Giuseppe, Melino, Gerry, Locatelli, Franco, Gulino, Alberto, Ayrault, Olivier, Fruci, Doriana, Di Marcotullio, Lucia
Publicado 2019

Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance

por Rasool, Reyaz ur, O’Connor, Caitlin M., Das, Chandan Kanta, Alhusayan, Mohammed, Verma, Brijesh Kumar, Islam, Sehbanul, Frohner, Ingrid E., Deng, Qu, Mitchell-Velasquez, Erick, Sangodkar, Jaya, Ahmed, Aqila, Linauer, Sarah, Mudrak, Ingrid, Rainey, Jessica, Zawacki, Kaitlin P., Suhan, Tahra K., Callahan, Catherine G., Rebernick, Ryan, Natesan, Ramakrishnan, Siddiqui, Javed, Sauter, Guido, Thomas, Dafydd, Wang, Shaomeng, Taylor, Derek J., Simon, Ronald, Cieslik, Marcin, Chinnaiyan, Arul M., Busino, Luca, Ogris, Egon, Narla, Goutham, Asangani, Irfan A.
Publicado 2023