Oral Administration of PF-01247324, a Subtype-Selective Nav1.8 Blocker, Reverses Cerebellar Deficits in a Mouse Model of Multiple Sclerosis

por Shields, Shannon D., Butt, Richard P., Dib-Hajj, Sulayman D., Waxman, Stephen G.
Publicado 2015

Lack of Detection of the Analgesic Properties of PF‐05089771, a Selective Na(v)1.7 Inhibitor, Using a Battery of Pain Models in Healthy Subjects

por Siebenga, Pieter, van Amerongen, Guido, Hay, Justin L., McDonnell, Aoibhinn, Gorman, Donal, Butt, Richard, Groeneveld, Geert Jan
Publicado 2019

Reproducibility of a battery of human evoked pain models to detect pharmacological effects of analgesic drugs

por Siebenga, Pieter S., van Amerongen, Guido, Okkerse, Pieter, Denney, William S., Dua, Pinky, Butt, Richard P., Hay, Justin L., Groeneveld, Geert J.
Publicado 2019

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

por Alexandrou, Aristos J., Brown, Adam R., Chapman, Mark L., Estacion, Mark, Turner, Jamie, Mis, Malgorzata A., Wilbrey, Anna, Payne, Elizabeth C., Gutteridge, Alex, Cox, Peter J., Doyle, Rachel, Printzenhoff, David, Lin, Zhixin, Marron, Brian E., West, Christopher, Swain, Nigel A., Storer, R. Ian, Stupple, Paul A., Castle, Neil A., Hounshell, James A., Rivara, Mirko, Randall, Andrew, Dib-Hajj, Sulayman D., Krafte, Douglas, Waxman, Stephen G., Patel, Manoj K., Butt, Richard P., Stevens, Edward B.
Publicado 2016