Pharmacological induction of translational readthrough of nonsense mutations in the retinoblastoma (RB1) gene

por Palomar-Siles, Mireia, Yurevych, Viktor, Bykov, Vladimir J. N., Wiman, Klas G.
Publicado 2023

APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

por Zhang, Qiang, Bykov, Vladimir J. N., Wiman, Klas G., Zawacka-Pankau, Joanna
Publicado 2018

p53 as a hub in cellular redox regulation and therapeutic target in cancer

por Eriksson, Sofi E, Ceder, Sophia, Bykov, Vladimir J N, Wiman, Klas G
Publicado 2019

Correction: APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

por Zhang, Qiang, Bykov, Vladimir J. N., Wiman, Klas G., Zawacka-Pankau, Joanna
Publicado 2019

PRIMA-1(MET) Inhibits Growth of Mouse Tumors Carrying Mutant p53

por Zache, Nicole, Lambert, Jeremy M. R., Wiman, Klas G., Bykov, Vladimir J. N.
Publicado 2008

Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy

por Bykov, Vladimir J. N., Zhang, Qiang, Zhang, Meiqiongzi, Ceder, Sophia, Abrahmsen, Lars, Wiman, Klas G.
Publicado 2016

Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors

por Zhang, Meiqiongzi, Heldin, Angelos, Palomar-Siles, Mireia, Öhlin, Susanne, Bykov, Vladimir J. N., Wiman, Klas G.
Publicado 2018

Ipidacrine (Axamon), A Reversible Cholinesterase Inhibitor, Improves Erectile Function in Male Rats With Diabetes Mellitus-Induced Erectile Dysfunction

por Bykov, Vladimir, Gushchina, Evgenia, Morozov, Sergey, Zhuravskaya, Natalia, Kryshen, Kirill, Makarov, Valery, Matichin, Aleksandr, Zueva, Alena
Publicado 2022

The Mutant p53-Targeting Compound APR-246 Induces ROS-Modulating Genes in Breast Cancer Cells

por Synnott, Naoise C., Madden, Stephen F., Bykov, Vladimir J.N., Crown, John, Wiman, Klas G., Duffy, Michael J.
Publicado 2018

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

por Haffo, Lena, Lu, Jun, Bykov, Vladimir J. N., Martin, Sebastin S., Ren, Xiaoyuan, Coppo, Lucia, Wiman, Klas G., Holmgren, Arne
Publicado 2018

APR-246/PRIMA-1(MET) inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase

por Peng, Xiaoxiao, Zhang, Mei-Qiong-Zi, Conserva, Francesca, Hosny, Gihan, Selivanova, Galina, Bykov, Vladimir JN, Arnér, Elias SJ, Wiman, Klas G
Publicado 2017

Human cancer-associated fibroblasts enhance glutathione levels and antagonize drug-induced prostate cancer cell death

por Cheteh, Emarndeena H, Augsten, Martin, Rundqvist, Helene, Bianchi, Julie, Sarne, Victoria, Egevad, Lars, Bykov, Vladimir JN, Östman, Arne, Wiman, Klas G
Publicado 2017

Mutant p53 targeting by the low molecular weight compound STIMA‐1

por Zache, Nicole, Lambert, Jeremy M.R., Rökaeus, Nina, Shen, Jinfeng, Hainaut, Pierre, Bergman, Jan, Wiman, Klas G., Bykov, Vladimir J.N.
Publicado 2017

Novel compounds that synergize with aminoglycoside G418 or eRF3 degraders for translational readthrough of nonsense mutant TP53 and PTEN

por Heldin, Angelos, Cancer, Matko, Palomar-Siles, Mireia, Öhlin, Susanne, Zhang, Meiqiongzi, Sun-Zhang, Alexander, Mariani, Anna, Liu, Jianping, Bykov, Vladimir J.N., Wiman, Klas G.
Publicado 2023

Translational readthrough of nonsense mutant TP53 by mRNA incorporation of 5-Fluorouridine

por Palomar-Siles, Mireia, Heldin, Angelos, Zhang, Meiqiongzi, Strandgren, Charlotte, Yurevych, Viktor, van Dinter, Jip T., Engels, Sem A. G., Hofman, Damon A., Öhlin, Susanne, Meineke, Birthe, Bykov, Vladimir J. N., van Heesch, Sebastiaan, Wiman, Klas G.
Publicado 2022

Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

por Ceder, Sophia, Eriksson, Sofi E., Liang, Ying Yu, Cheteh, Emarndeena H., Zhang, Si Min, Fujihara, Kenji M., Bianchi, Julie, Bykov, Vladimir J. N., Abrahmsen, Lars, Clemons, Nicholas J., Nordlund, Pär, Rudd, Sean G., Wiman, Klas G.
Publicado 2021

Correction: Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

por Ceder, Sophia, Eriksson, Sofi E., Liang, Ying Yu, Cheteh, Emarndeena H., Zhang, Si Min, Fujihara, Kenji M., Bianchi, Julie, Bykov, Vladimir J. N., Abrahmsen, Lars, Clemons, Nicholas J., Nordlund, Pär, Rudd, Sean G., Wiman, Klas G.
Publicado 2022

Results and prospects of development of new polyphenolic drugs for cancer patients

por Anisimov, Vladimir N., Larsen, Stig, Lofberg, Stig, Baldueva, Irina A., Malek, Anastasia V., Nielsen, Tea Kirkegaard, Fedoros, Elena I., Perminova, Irina V., Drobyshev, Evgeny Yu., Bykov, Vladimir N., Panchenko, Andrey V., Scherbakov, Alexander M., Belyaev, Alexey M.
Publicado 2017

A thiol‐bound drug reservoir enhances APR‐246‐induced mutant p53 tumor cell death

por Ceder, Sophia, Eriksson, Sofi E, Cheteh, Emarndeena H, Dawar, Swati, Corrales Benitez, Mariana, Bykov, Vladimir J N, Fujihara, Kenji M, Grandin, Mélodie, Li, Xiaodun, Ramm, Susanne, Behrenbruch, Corina, Simpson, Kaylene J, Hollande, Frédéric, Abrahmsen, Lars, Clemons, Nicholas J, Wiman, Klas G
Publicado 2020