Platyhelminth Venom Allergen-Like (VAL) proteins: revealing structural diversity, class-specific features and biological associations across the phylum

por CHALMERS, IAIN W., HOFFMANN, KARL F.
Publicado 2012

Development and Validation of a Quantitative, High-Throughput, Fluorescent-Based Bioassay to Detect Schistosoma Viability

por Peak, Emily, Chalmers, Iain W., Hoffmann, Karl F.
Publicado 2010

Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities

por Padalino, Gilda, Chalmers, Iain W., Brancale, Andrea, Hoffmann, Karl F.
Publicado 2020

Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni

por Padalino, Gilda, Ferla, Salvatore, Brancale, Andrea, Chalmers, Iain W., Hoffmann, Karl F.
Publicado 2018

Erratum to ‘Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni’ [IJP Drugs...

por Padalino, Gilda, Ferla, Salvatore, Brancale, Andrea, Chalmers, Iain W., Hoffmann, Karl F.
Publicado 2019

Protective human IgE responses are promoted by comparable life-cycle dependent Tegument Allergen-Like expression in Schistosoma haematobium and Schistosoma mansoni infection

por Oettle, Rebecca C., Dickinson, Harriet A., Fitzsimmons, Colin M., Sacko, Moussa, Tukahebwa, Edridah M., Chalmers, Iain W., Wilson, Shona
Publicado 2023

Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family

por Chalmers, Iain W, McArdle, Andrew J, Coulson, Richard MR, Wagner, Marissa A, Schmid, Ralf, Hirai, Hirohisa, Hoffmann, Karl F
Publicado 2008

Anti-schistosomal Intervention Targets Identified by Lifecycle Transcriptomic Analyses

por Fitzpatrick, Jennifer M., Peak, Emily, Perally, Samirah, Chalmers, Iain W., Barrett, John, Yoshino, Timothy P., Ivens, Alasdair C., Hoffmann, Karl F.
Publicado 2009

Cytosine methylation regulates oviposition in the pathogenic blood fluke Schistosoma mansoni

por Geyer, Kathrin K., Rodríguez López, Carlos M., Chalmers, Iain W., Munshi, Sabrina E., Truscott, Martha, Heald, James, Wilkinson, Mike J., Hoffmann, Karl F.
Publicado 2011

The Schistosoma mansoni Tegumental-Allergen-Like (TAL) Protein Family: Influence of Developmental Expression on Human IgE Responses

por Fitzsimmons, Colin M., Jones, Frances M., Stearn, Alex, Chalmers, Iain W., Hoffmann, Karl F., Wawrzyniak, Jakub, Wilson, Shona, Kabatereine, Narcis B., Dunne, David W.
Publicado 2012

Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes

por Geyer, Kathrin K, Chalmers, Iain W, MacKintosh, Neil, Hirst, Julie E, Geoghegan, Rory, Badets, Mathieu, Brophy, Peter M, Brehm, Klaus, Hoffmann, Karl F
Publicado 2013

Excreted/secreted Schistosoma mansoni venom allergen-like 9 (SmVAL9) modulates host extracellular matrix remodelling gene expression

por Yoshino, Timothy P., Brown, Martha, Wu, Xiao-Jun, Jackson, Colin J., Ocadiz-Ruiz, Ramon, Chalmers, Iain W., Kolb, Marlen, Hokke, Cornelis H., Hoffmann, Karl F.
Publicado 2014

The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets

por Whatley, Kezia C. L., Padalino, Gilda, Whiteland, Helen, Geyer, Kathrin K., Hulme, Benjamin J., Chalmers, Iain W., Forde-Thomas, Josephine, Ferla, Salvatore, Brancale, Andrea, Hoffmann, Karl F.
Publicado 2019

Schistosoma mansoni Larval Extracellular Vesicle protein 1 (SmLEV1) is an immunogenic antigen found in EVs released from pre-acetabular glands of invading cercariae

por Gasan, Thomas A., Kuipers, Marije E., Roberts, Grisial H., Padalino, Gilda, Forde-Thomas, Josephine E., Wilson, Shona, Wawrzyniak, Jakub, Tukahebwa, Edridah M., Hoffmann, Karl F., Chalmers, Iain W.
Publicado 2021

Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes

por Padalino, Gilda, Celatka, Cassandra A., Rienhoff Jr., Hugh Y., Kalin, Jay H., Cole, Philip A., Lassalle, Damien, Forde-Thomas, Josephine, Chalmers, Iain W., Brancale, Andrea, Grunau, Christoph, Hoffmann, Karl F.
Publicado 2023

Human IgG(1) Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment

por Chalmers, Iain W., Fitzsimmons, Colin M., Brown, Martha, Pierrot, Christine, Jones, Frances M., Wawrzyniak, Jakub M., Fernandez-Fuentes, Narcis, Tukahebwa, Edridah M., Dunne, David W., Khalife, Jamal, Hoffmann, Karl F.
Publicado 2015

Schistosoma mansoni schistosomula antigens induce Th1/Pro‐inflammatory cytokine responses

por Egesa, Moses, Lubyayi, Lawrence, Tukahebwa, Edridah M., Bagaya, Bernard S., Chalmers, Iain W., Wilson, Shona, Hokke, Cornelis H., Hoffmann, Karl F., Dunne, David W., Yazdanbakhsh, Maria, Labuda, Lucja A., Cose, Stephen
Publicado 2018

Known Allergen Structures Predict Schistosoma mansoni IgE-Binding Antigens in Human Infection

por Farnell, Edward J., Tyagi, Nidhi, Ryan, Stephanie, Chalmers, Iain W., Pinot de Moira, Angela, Jones, Frances M., Wawrzyniak, Jakub, Fitzsimmons, Colin M., Tukahebwa, Edridah M., Furnham, Nicholas, Maizels, Rick M., Dunne, David W.
Publicado 2015

Drug-Induced Exposure of Schistosoma mansoni Antigens SmCD59a and SmKK7

por Reimers, Natalie, Homann, Arne, Höschler, Beate, Langhans, Kristina, Wilson, R. Alan, Pierrot, Christine, Khalife, Jamal, Grevelding, Christoph G., Chalmers, Iain W., Yazdanbakhsh, Maria, Hoffmann, Karl F., Hokke, Cornelis H., Haas, Helmut, Schramm, Gabriele
Publicado 2015

The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with...

por Geyer, Kathrin K., Niazi, Umar H., Duval, David, Cosseau, Céline, Tomlinson, Chad, Chalmers, Iain W., Swain, Martin T., Cutress, David J., Bickham-Wright, Utibe, Munshi, Sabrina E., Grunau, Christoph, Yoshino, Timothy P., Hoffmann, Karl F.
Publicado 2017