270 SYN-004, a Class A Beta-Lactamase Therapy for the Prevention of Antibiotic-Induced Disruption of Intestinal Microflora

por Kaleko, Michael, Bristol, Andrew, Connelly, Sheila, Koski, Pertti
Publicado 2014

Identification, Characterization, and Formulation of a Novel Carbapenemase Intended to Prevent Antibiotic-Mediated Gut Dysbiosis

por Connelly, Sheila, Parsley, Todd, Ge, Hui, Kaleko, Michael
Publicado 2019

Passive Immunization with Anti-Pertussis Toxin Humanized Monoclonal Antibody Mitigates Clinical Signs of Pertussis Infection in Newborn Baboons

por Maynard, Jennifer, Nguyen, Annalee, Wolf, Roman, Papin, James, Connelly, Sheila, Kaleko, Michael
Publicado 2017

Oral Metallo-Beta-Lactamase Protects the Gut Microbiome From Carbapenem-Mediated Damage and Reduces Propagation of Antibiotic Resistance in Pigs

por Connelly, Sheila, Fanelli, Brian, Hasan, Nur A., Colwell, Rita R., Kaleko, Michael
Publicado 2019

Oral Beta-Lactamase Protects the Canine Gut Microbiome from Oral Amoxicillin-Mediated Damage

por Connelly, Sheila, Fanelli, Brian, Hasan, Nur A., Colwell, Rita R., Kaleko, Michael
Publicado 2019

Low dose oral beta-lactamase protects the gut microbiome from oral beta-lactam-mediated damage in dogs

por Connelly, Sheila, Fanelli, Brian, Hasan, Nur A., Colwell, Rita R., Kaleko, Michael
Publicado 2019

SYN-007, an Orally Administered Beta-Lactamase Enzyme, Protects the Gut Microbiome from Oral Amoxicillin/Clavulanate without Adversely Affecting Antibiotic Systemic Absorption in D...

por Connelly, Sheila, Fanelli, Brian, Hasan, Nur A., Colwell, Rita R., Kaleko, Michael
Publicado 2020

620. Oral β-Lactamase Therapies Prevent Microbiome Damage and Attenuate Antibiotic Resistance From IV and Oral Antibiotics in Large Animal Models of Antibiotic-Mediated Gut Dysbios...

por Connelly, Sheila, Furlan-Freguia, Christian, Fanelli, Brian, Hasan, Nur A, Colwell, Rita R, Kaleko, Michael
Publicado 2018

673. Novel Delayed-Release Formulation of an Oral β-Lactamase Prevents Gut Microbiome Damage and Attenuates Antibiotic Resistance Caused by Oral Amoxicillin/Clavulanate without Int...

por Connelly, Sheila, Furlan-Freguia, Christian, Fanelli, Brian, Hasan, Nur A, Colwell, Rita R, Kaleko, Michael
Publicado 2019

Neutralization of pertussis toxin by a single antibody prevents clinical pertussis in neonatal baboons

por Nguyen, Annalee W., DiVenere, Andrea M., Papin, James F., Connelly, Sheila, Kaleko, Michael, Maynard, Jennifer A.
Publicado 2020

Ribaxamase, an Orally Administered β-Lactamase, Diminishes Changes to Acquired Antimicrobial Resistance of the Gut Resistome in Patients Treated with Ceftriaxone

por Kokai-Kun, John F, Le, Chenxiong, Trout, Kenneth, Cope, Julia L, Ajami, Nadim J, Degar, Andrew J, Connelly, Sheila
Publicado 2020

Prior exposure to Bordetella species as an exclusion criterion in the baboon model of pertussis

por NGUYEN, Annalee W., WAGNER, Ellen K., POSADA, Luciano, LIU, Xinlei, CONNELLY, Sheila, PAPIN, James F., WOLF, Roman F., KALEKO, Michael, MAYNARD, Jennifer A.
Publicado 2016