Determination of antiprotozoal drug mechanisms by metabolomics approaches

por CREEK, DARREN J., BARRETT, MICHAEL P.
Publicado 2014

Current and emerging target identification methods for novel antimalarials

por Challis, Matthew P., Devine, Shane M., Creek, Darren J.
Publicado 2022

Optimized Method for Untargeted Metabolomics Analysis of MDA-MB-231 Breast Cancer Cells

por Peterson, Amanda L., Walker, Adam K., Sloan, Erica K., Creek, Darren J.
Publicado 2016

Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics

por Trochine, Andrea, Creek, Darren J., Faral-Tello, Paula, Barrett, Michael P., Robello, Carlos
Publicado 2014

Synergistic Killing of Polymyxin B in Combination With the Antineoplastic Drug Mitotane Against Polymyxin-Susceptible and -Resistant Acinetobacter baumannii: A Metabolomic Study

por Tran, Thien B., Bergen, Phillip J., Creek, Darren J., Velkov, Tony, Li, Jian
Publicado 2018

mzMatch–ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data

por Chokkathukalam, Achuthanunni, Jankevics, Andris, Creek, Darren J., Achcar, Fiona, Barrett, Michael P., Breitling, Rainer
Publicado 2013

Strategies for Extending Metabolomics Studies with Stable Isotope Labelling and Fluxomics

por Srivastava, Anubhav, Kowalski, Greg M., Callahan, Damien L., Meikle, Peter J., Creek, Darren J.
Publicado 2016

Metabolomes and Lipidomes of the Infective Stages of the Gastrointestinal nematodes, Nippostrongylus brasiliensis and Trichuris muris

por Yeshi, Karma, Creek, Darren J., Anderson, Dovile, Ritmejerytė, Edita, Becker, Luke, Loukas, Alex, Wangchuk, Phurpa
Publicado 2020

Red Blood Cell BCL-x(L) Is Required for Plasmodium falciparum Survival: Insights into Host-Directed Malaria Therapies

por Boulet, Coralie, Siddiqui, Ghizal, Gaynor, Taylah L., Doerig, Christian, Creek, Darren J., Carvalho, Teresa G.
Publicado 2022

Integrated metabolomic and transcriptomic analyses of the synergistic effect of polymyxin–rifampicin combination against Pseudomonas aeruginosa

por Mahamad Maifiah, Mohd Hafidz, Zhu, Yan, Tsuji, Brian T., Creek, Darren J., Velkov, Tony, Li, Jian
Publicado 2022

Stable Isotope-Assisted Metabolomics for Network-Wide Metabolic Pathway Elucidation

por Creek, Darren J., Chokkathukalam, Achuthanunni, Jankevics, Andris, Burgess, Karl E. V., Breitling, Rainer, Barrett, Michael P.
Publicado 2012

Measuring Sulforaphane and Its Metabolites in Human Plasma: A High Throughput Method

por Langston-Cox, Annie, Anderson, Dovile, Creek, Darren J., Palmer, Kirsten, Wallace, Euan M., Marshall, Sarah A.
Publicado 2020

Untargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei

por Vincent, Isabel M., Creek, Darren J., Burgess, Karl, Woods, Debra J., Burchmore, Richard J. S., Barrett, Michael P.
Publicado 2012

The 2-methylcitrate cycle is implicated in the detoxification of propionate in Toxoplasma gondii

por Limenitakis, Julien, Oppenheim, Rebecca D, Creek, Darren J, Foth, Bernardo J, Barrett, Michael P, Soldati-Favre, Dominique
Publicado 2013

Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against Acinetobacter baumannii

por Maifiah, Mohd Hafidz Mahamad, Creek, Darren J., Nation, Roger L., Forrest, Alan, Tsuji, Brian T., Velkov, Tony, Li, Jian
Publicado 2017

System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion

por Giannangelo, Carlo, Siddiqui, Ghizal, De Paoli, Amanda, Anderson, Bethany M., Edgington-Mitchell, Laura E., Charman, Susan A., Creek, Darren J.
Publicado 2020

Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strain...

por Yang, Tuo, Xie, Stanley C., Cao, Pengxing, Giannangelo, Carlo, McCaw, James, Creek, Darren J., Charman, Susan A., Klonis, Nectarios, Tilley, Leann
Publicado 2016

The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism

por Pitman, Melissa R., Lewis, Alexander C., Davies, Lorena T., Moretti, Paul A. B., Anderson, Dovile, Creek, Darren J., Powell, Jason A., Pitson, Stuart M.
Publicado 2022

Host Reticulocytes Provide Metabolic Reservoirs That Can Be Exploited by Malaria Parasites

por Srivastava, Anubhav, Creek, Darren J., Evans, Krystal J., De Souza, David, Schofield, Louis, Müller, Sylke, Barrett, Michael P., McConville, Malcolm J., Waters, Andrew P.
Publicado 2015

Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii

por Kloehn, Joachim, Oppenheim, Rebecca D., Siddiqui, Ghizal, De Bock, Pieter-Jan, Kumar Dogga, Sunil, Coute, Yohann, Hakimi, Mohamed-Ali, Creek, Darren J., Soldati-Favre, Dominique
Publicado 2020