Limitations in the Design of Chimeric Antigen Receptors for Cancer Therapy

por Stoiber, Stefan, Cadilha, Bruno L., Benmebarek, Mohamed-Reda, Lesch, Stefanie, Endres, Stefan, Kobold, Sebastian
Publicado 2019

Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells

por Benmebarek, Mohamed-Reda, Karches, Clara Helke, Cadilha, Bruno Loureiro, Lesch, Stefanie, Endres, Stefan, Kobold, Sebastian
Publicado 2019

PD1-CD28 Fusion Protein Enables CD4+ T Cell Help for Adoptive T Cell Therapy in Models of Pancreatic Cancer and Non-hodgkin Lymphoma

por Rataj, Felicitas, Kraus, Fabian B. T., Chaloupka, Michael, Grassmann, Simon, Heise, Constanze, Cadilha, Bruno L., Duewell, Peter, Endres, Stefan, Kobold, Sebastian
Publicado 2018

Microphthalmia-Associated Transcription Factor (MITF) Regulates Immune Cell Migration into Melanoma

por Wiedemann, Gabriela M, Aithal, Celina, Kraechan, Angelina, Heise, Constanze, Cadilha, Bruno L, Zhang, Jin, Duewell, Peter, Ballotti, Robert, Endres, Stefan, Bertolotto, Corine, Kobold, Sebastian
Publicado 2018

High-affinity CD16-polymorphism and Fc-engineered antibodies enable activity of CD16-chimeric antigen receptor-modified T cells for cancer therapy

por Rataj, Felicitas, Jacobi, Severin J., Stoiber, Stefan, Asang, Florian, Ogonek, Justyna, Tokarew, Nicholas, Cadilha, Bruno L., van Puijenbroek, Erwin, Heise, Constanze, Duewell, Peter, Endres, Stefan, Klein, Christian, Kobold, Sebastian
Publicado 2018

Paralysis of the cytotoxic granule machinery is a new cancer immune evasion mechanism mediated by chitinase 3-like-1

por Darwich, Abbass, Silvestri, Alessandra, Benmebarek, Mohamed-Reda, Mouriès, Juliette, Cadilha, Bruno, Melacarne, Alessia, Morelli, Lapo, Supino, Domenico, Taleb, Alexandre, Obeck, Hannah, Sustmann, Claudio, Losurdo, Agnese, Masci, Giovanna, Curigliano, Giuseppe, Kobold, Sebastian, Penna, Giuseppe, Rescigno, Maria
Publicado 2021

Advances in cancer immunotherapy 2019 – latest trends

por Kruger, Stephan, Ilmer, Matthias, Kobold, Sebastian, Cadilha, Bruno L., Endres, Stefan, Ormanns, Steffen, Schuebbe, Gesa, Renz, Bernhard W., D’Haese, Jan G., Schloesser, Hans, Heinemann, Volker, Subklewe, Marion, Boeck, Stefan, Werner, Jens, von Bergwelt-Baildon, Michael
Publicado 2019

Augmenting anti-CD19 and anti-CD22 CAR T-cell function using PD-1-CD28 checkpoint fusion proteins

por Blaeschke, Franziska, Stenger, Dana, Apfelbeck, Antonia, Cadilha, Bruno L., Benmebarek, Mohamed-Reda, Mahdawi, Jasmin, Ortner, Eva, Lepenies, Mareike, Habjan, Nicola, Rataj, Felicitas, Willier, Semjon, Kaeuferle, Theresa, Majzner, Robbie G., Busch, Dirk H., Kobold, Sebastian, Feuchtinger, Tobias
Publicado 2021

Rational design of PD-1-CD28 immunostimulatory fusion proteins for CAR T cell therapy

por Lorenzini, Theo, Cadilha, Bruno L., Obeck, Hannah, Benmebarek, Mohamed-Reda, Märkl, Florian, Michaelides, Stefanos, Strzalkowski, Thaddäus, Briukhovetska, Daria, Müller, Philipp Jie, Nandi, Sayantan, Winter, Pia, Majed, Lina, Grünmeier, Ruth, Seifert, Matthias, Rausch, Svenja, Feuchtinger, Tobias, Endres, Stefan, Kobold, Sebastian
Publicado 2023

Targeting the CBM complex causes Treg cells to prime tumors for immune checkpoint therapy

por Pilato, Mauro Di, Kim, Edward Y., Cadilha, Bruno L., Pruessmann, Jasper N., Nasrallah, Mazen N., Seruggia, Davide, Usmani, Shariq M., Misale, Sandra, Zappulli, Valentina, Carrizosa, Esteban, Mani, Vinidhra, Ligorio, Matteo, Warner, Ross D., Medoff, Benjamin D., Marangoni, Francesco, Villani, Alexandra-Chloe, Mempel, Thorsten R.
Publicado 2019

Impact of the selective A2(A)R and A2(B)R dual antagonist AB928/etrumadenant on CAR T cell function

por Seifert, Matthias, Benmebarek, Mohamed-Reda, Briukhovetska, Daria, Märkl, Florian, Dörr, Janina, Cadilha, Bruno L., Jobst, Jakob, Stock, Sophia, Andreu-Sanz, David, Lorenzini, Theo, Grünmeier, Ruth, Oner, Arman, Obeck, Hannah, Majed, Lina, Dhoqina, Dario, Feinendegen, Manouk, Gottschlich, Adrian, Zhang, Jin, Schindler, Ulrike, Endres, Stefan, Kobold, Sebastian
Publicado 2022

A modular and controllable T cell therapy platform for acute myeloid leukemia

por Benmebarek, Mohamed-Reda, Cadilha, Bruno L., Herrmann, Monika, Lesch, Stefanie, Schmitt, Saskia, Stoiber, Stefan, Darwich, Abbass, Augsberger, Christian, Brauchle, Bettina, Rohrbacher, Lisa, Oner, Arman, Seifert, Matthias, Schwerdtfeger, Melanie, Gottschlich, Adrian, Rataj, Felicitas, Fenn, Nadja C., Klein, Christian, Subklewe, Marion, Endres, Stefan, Hopfner, Karl-Peter, Kobold, Sebastian
Publicado 2021

Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma

por Hölting, Tilman L. B., Cidre-Aranaz, Florencia, Matzek, Dana, Popper, Bastian, Jacobi, Severin J., Funk, Cornelius M., Geyer, Florian H., Li, Jing, Piseddu, Ignazio, Cadilha, Bruno L., Ledderose, Stephan, Zwilling, Jennifer, Ohmura, Shunya, Anz, David, Künkele, Annette, Klauschen, Frederick, Grünewald, Thomas G. P., Knott, Maximilian M. L.
Publicado 2022

Skin dendritic cells in melanoma are key for successful checkpoint blockade therapy

por Prokopi, Anastasia, Tripp, Christoph H, Tummers, Bart, Hornsteiner, Florian, Spoeck, Sarah, Crawford, Jeremy Chase, Clements, Derek R, Efremova, Mirjana, Hutter, Katharina, Bellmann, Lydia, Cappellano, Giuseppe, Cadilha, Bruno L, Kobold, Sebastian, Boon, Louis, Ortner, Daniela, Trajanoski, Zlatko, Chen, Suzie, de Gruijl, Tanja D, Idoyaga, Juliana, Green, Douglas R, Stoitzner, Patrizia
Publicado 2021

Epithelial-type systemic breast carcinoma cells with a restricted mesenchymal transition are a major source of metastasis

por Liu, Xiao, Li, Junjian, Cadilha, Bruno Loureiro, Markota, Anamarija, Voigt, Cornelia, Huang, Zhe, Lin, Peter P., Wang, Daisy D., Dai, Juncheng, Kranz, Gisela, Krandick, Anna, Libl, Darko, Zitzelsberger, Horst, Zagorski, Isabella, Braselmann, Herbert, Pan, Min, Zhu, Sibo, Huang, Yuanchi, Niedermeyer, Sebastian, Reichel, Christoph A., Uhl, Bernd, Briukhovetska, Daria, Suárez, Javier, Kobold, Sebastian, Gires, Olivier, Wang, Hongxia
Publicado 2019

In vivo dynamics and anti-tumor effects of EpCAM-directed CAR T-cells against brain metastases from lung cancer

por Xu, Tao, Karschnia, Philipp, Cadilha, Bruno Loureiro, Dede, Sertac, Lorenz, Michael, Seewaldt, Niklas, Nikolaishvili, Elene, Müller, Katharina, Blobner, Jens, Teske, Nico, Herold, Julika J., Rejeski, Kai, Langer, Sigrid, Obeck, Hannah, Lorenzini, Theo, Mulazzani, Matthias, Zhang, Wenlong, Ishikawa-Ankerhold, Hellen, Buchholz, Veit R., Subklewe, Marion, Thon, Niklas, Straube, Andreas, Tonn, Joerg-Christian, Kobold, Sebastian, von Baumgarten, Louisa
Publicado 2023

Bispecific antibodies redirect synthetic agonistic receptor modified T cells against melanoma

por Märkl, Florian, Benmebarek, Mohamed-Reda, Keyl, Julius, Cadilha, Bruno L, Geiger, Martina, Karches, Clara, Obeck, Hannah, Schwerdtfeger, Melanie, Michaelides, Stefanos, Briukhovetska, Daria, Stock, Sophia, Jobst, Jakob, Müller, Philipp Jie, Majed, Lina, Seifert, Matthias, Klüver, Anna-Kristina, Lorenzini, Theo, Grünmeier, Ruth, Thomas, Moritz, Gottschlich, Adrian, Klaus, Richard, Marr, Carsten, von Bergwelt-Baildon, Michael, Rothenfusser, Simon, Levesque, Mitchell P, Heppt, Markus Vincent, Endres, Stefan, Klein, Christian, Kobold, Sebastian
Publicado 2023

Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors

por Cadilha, Bruno L., Benmebarek, Mohamed-Reda, Dorman, Klara, Oner, Arman, Lorenzini, Theo, Obeck, Hannah, Vänttinen, Mira, Di Pilato, Mauro, Pruessmann, Jasper N., Stoiber, Stefan, Huynh, Duc, Märkl, Florian, Seifert, Matthias, Manske, Katrin, Suarez-Gosalvez, Javier, Zeng, Yi, Lesch, Stefanie, Karches, Clara H., Heise, Constanze, Gottschlich, Adrian, Thomas, Moritz, Marr, Carsten, Zhang, Jin, Pandey, Dharmendra, Feuchtinger, Tobias, Subklewe, Marion, Mempel, Thorsten R., Endres, Stefan, Kobold, Sebastian
Publicado 2021

T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis

por Briukhovetska, Daria, Suarez-Gosalvez, Javier, Voigt, Cornelia, Markota, Anamarija, Giannou, Anastasios D., Schübel, Maryam, Jobst, Jakob, Zhang, Tao, Dörr, Janina, Märkl, Florian, Majed, Lina, Müller, Philipp Jie, May, Peter, Gottschlich, Adrian, Tokarew, Nicholas, Lücke, Jöran, Oner, Arman, Schwerdtfeger, Melanie, Andreu-Sanz, David, Grünmeier, Ruth, Seifert, Matthias, Michaelides, Stefanos, Hristov, Michael, König, Lars M., Cadilha, Bruno Loureiro, Mikhaylov, Oleg, Anders, Hans-Joachim, Rothenfusser, Simon, Flavell, Richard A., Cerezo-Wallis, Daniela, Tejedo, Cristina, Soengas, María S., Bald, Tobias, Huber, Samuel, Endres, Stefan, Kobold, Sebastian
Publicado 2023

Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia

por Gottschlich, Adrian, Thomas, Moritz, Grünmeier, Ruth, Lesch, Stefanie, Rohrbacher, Lisa, Igl, Veronika, Briukhovetska, Daria, Benmebarek, Mohamed-Reda, Vick, Binje, Dede, Sertac, Müller, Katharina, Xu, Tao, Dhoqina, Dario, Märkl, Florian, Robinson, Sophie, Sendelhofert, Andrea, Schulz, Heiko, Umut, Öykü, Kavaka, Vladyslav, Tsiverioti, Christina Angeliki, Carlini, Emanuele, Nandi, Sayantan, Strzalkowski, Thaddäus, Lorenzini, Theo, Stock, Sophia, Müller, Philipp Jie, Dörr, Janina, Seifert, Matthias, Cadilha, Bruno L., Brabenec, Ruben, Röder, Natalie, Rataj, Felicitas, Nüesch, Manuel, Modemann, Franziska, Wellbrock, Jasmin, Fiedler, Walter, Kellner, Christian, Beltrán, Eduardo, Herold, Tobias, Paquet, Dominik, Jeremias, Irmela, von Baumgarten, Louisa, Endres, Stefan, Subklewe, Marion, Marr, Carsten, Kobold, Sebastian
Publicado 2023