Design, Synthesis and Biological Evaluation of Quinazolinamine Derivatives as Breast Cancer Resistance Protein and P-Glycoprotein Inhibitors with Improved Metabolic Stability

por Cai, Chao-Yun, Teng, Qiu-Xu, Murakami, Megumi, Ambudkar, Suresh V., Chen, Zhe-Sheng, Korlipara, Vijaya L.
Publicado 2023

Y(6), an Epigallocatechin Gallate Derivative, Reverses ABCG2-Mediated Mitoxantrone Resistance

por Zhao, Rui-Qiang, Wen, Yan, Gupta, Pranav, Lei, Zi-Ning, Cai, Chao-Yun, Liang, Gang, Yang, Dong-Hua, Chen, Zhe-Sheng, Xie, Yu-An
Publicado 2019

Olmutinib (BI1482694/HM61713), a Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Reverses ABCG2-Mediated Multidrug Resistance in Cancer Cells

por Zhang, Wei, Fan, Ying-Fang, Cai, Chao-Yun, Wang, Jing-Quan, Teng, Qiu-Xu, Lei, Zi-Ning, Zeng, Leli, Gupta, Pranav, Chen, Zhe-Sheng
Publicado 2018

Chk1 Inhibitor MK-8776 Restores the Sensitivity of Chemotherapeutics in P-glycoprotein Overexpressing Cancer Cells

por Cui, Qingbin, Cai, Chao-Yun, Wang, Jing-Quan, Zhang, Shuang, Gupta, Pranav, Ji, Ning, Yang, Yuqi, Dong, Xingduo, Yang, Dong-Hua, Chen, Zhe-Sheng
Publicado 2019

VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters

por Ji, Ning, Yang, Yuqi, Cai, Chao-Yun, Lei, Zi-Ning, Wang, Jing-Quan, Gupta, Pranav, Teng, Qiu-Xu, Chen, Zhe-Sheng, Kong, Dexin, Yang, Dong-Hua
Publicado 2018

Midostaurin Reverses ABCB1-Mediated Multidrug Resistance, an in vitro Study

por Ji, Ning, Yang, Yuqi, Cai, Chao-Yun, Wang, Jing-Quan, Lei, Zi-Ning, Wu, Zhuo-Xun, Cui, Qingbin, Yang, Dong-Hua, Chen, Zhe-Sheng, Kong, Dexin
Publicado 2019

Modulating the function of ABCB1: in vitro and in vivo characterization of sitravatinib, a tyrosine kinase inhibitor

por Yang, Yuqi, Ji, Ning, Cai, Chao‐Yun, Wang, Jing‐Quan, Lei, Zi‐Ning, Teng, Qiu‐Xu, Wu, Zhuo‐Xun, Cui, Qingbin, Pan, Yihang, Chen, Zhe‐Sheng
Publicado 2020

Glesatinib, a c-MET/SMO Dual Inhibitor, Antagonizes P-glycoprotein Mediated Multidrug Resistance in Cancer Cells

por Cui, Qingbin, Cai, Chao-Yun, Gao, Hai-Ling, Ren, Liang, Ji, Ning, Gupta, Pranav, Yang, Yuqi, Shukla, Suneet, Ambudkar, Suresh V., Yang, Dong-Hua, Chen, Zhe-Sheng
Publicado 2019

Tetrandrine Interaction with ABCB1 Reverses Multidrug Resistance in Cancer Cells Through Competition with Anti-Cancer Drugs Followed by Downregulation of ABCB1 Expression

por Liao, Dan, Zhang, Wei, Gupta, Pranav, Lei, Zi-Ning, Wang, Jing-Quan, Cai, Chao-Yun, Vera, Albert A. De, Zhang, Lei, Chen, Zhe-Sheng, Yang, Dong-Hua
Publicado 2019

Reversal Effect of ALK Inhibitor NVP-TAE684 on ABCG2-Overexpressing Cancer Cells

por Wang, Jingqiu, Wang, Jing-Quan, Cai, Chao-Yun, Cui, Qingbin, Yang, Yuqi, Wu, Zhuo-Xun, Dong, Xingduo, Zeng, Leli, Zhao, Linguo, Yang, Dong-Hua, Chen, Zhe-Sheng
Publicado 2020

Overexpression of ABCB1 Transporter Confers Resistance to mTOR Inhibitor WYE-354 in Cancer Cells

por Wang, Jingqiu, Yang, Dong-Hua, Yang, Yuqi, Wang, Jing-Quan, Cai, Chao-Yun, Lei, Zi-Ning, Teng, Qiu-Xu, Wu, Zhuo-Xun, Zhao, Linguo, Chen, Zhe-Sheng
Publicado 2020

Sitravatinib, a Tyrosine Kinase Inhibitor, Inhibits the Transport Function of ABCG2 and Restores Sensitivity to Chemotherapy-Resistant Cancer Cells in vitro

por Yang, Yuqi, Ji, Ning, Teng, Qiu-Xu, Cai, Chao-Yun, Wang, Jing-Quan, Wu, Zhuo-Xun, Lei, Zi-Ning, Lusvarghi, Sabrina, Ambudkar, Suresh V., Chen, Zhe-Sheng
Publicado 2020

Overexpression of ABCB1 Associated With the Resistance to the KRAS-G12C Specific Inhibitor ARS-1620 in Cancer Cells

por Dong, Xing-Duo, Zhang, Meng, Cai, Chao-Yun, Teng, Qiu-Xu, Wang, Jing-Quan, Fu, Yi-Ge, Cui, Qingbin, Patel, Ketankumar, Wang, Dong-Tao, Chen, Zhe-Sheng
Publicado 2022

Hsa-miR-3178/RhoB/PI3K/Akt, a novel signaling pathway regulates ABC transporters to reverse gemcitabine resistance in pancreatic cancer

por Gu, Jianyou, Huang, Wenjie, Wang, Xianxing, Zhang, Junfeng, Tao, Tian, Zheng, Yao, Liu, Songsong, Yang, Jiali, Chen, Zhe-Sheng, Cai, Chao-Yun, Li, Jinsui, Wang, Huaizhi, Fan, Yingfang
Publicado 2022

Establishment and Characterization of a Topotecan Resistant Non-small Cell Lung Cancer NCI-H460/TPT10 Cell Line

por Lei, Zi-Ning, Teng, Qiu-Xu, Zhang, Wei, Fan, Ying-Fang, Wang, Jing-Quan, Cai, Chao-Yun, Lu, Kimberly W., Yang, Dong-Hua, Wurpel, John N. D., Chen, Zhe-Sheng
Publicado 2020

VKNG-1 Antagonizes ABCG2-Mediated Multidrug Resistance via p-AKT and Bcl-2 Pathway in Colon Cancer: In Vitro and In Vivo Study

por Narayanan, Silpa, Fan, Ying-Fang, Gujarati, Nehaben A., Teng, Qiu-Xu, Wang, Jing-Quan, Cai, Chao-Yun, Yang, Yuqi, Chintalapati, Anirudh J., Lei, Yixiong, Korlipara, Vijaya L., Chen, Zhe-Sheng
Publicado 2021