Pregabalin as a Pain Therapeutic: Beyond Calcium Channels

por Alles, Sascha R. A., Cain, Stuart M., Snutch, Terrance P.
Publicado 2020

Thalamocortical neurons display suppressed burst-firing due to an enhanced I(h) current in a genetic model of absence epilepsy

por Cain, Stuart M., Tyson, John R., Jones, Karen L., Snutch, Terrance P.
Publicado 2014

The Cacna1h mutation in the GAERS model of absence epilepsy enhances T-type Ca(2+) currents by altering calnexin-dependent trafficking of Ca(v)3.2 channels

por Proft, Juliane, Rzhepetskyy, Yuriy, Lazniewska, Joanna, Zhang, Fang-Xiong, Cain, Stuart M., Snutch, Terrance P., Zamponi, Gerald W., Weiss, Norbert
Publicado 2017

Heantos-4, a natural plant extract used in the treatment of drug addiction, modulates T-type calcium channels and thalamocortical burst-firing

por Cain, Stuart M., Ahn, Soyon, Garcia, Esperanza, Zhang, Yiming, Waheed, Zeina, Tyson, John R., Yang, Yi, Van Sung, Tran, Phillips, Anthony G., Snutch, Terrance P.
Publicado 2016

Hyperexcitable superior colliculus and fatal brainstem spreading depolarization in a model of Sudden Unexpected Death in Epilepsy

por Cain, Stuart M., Bernier, Louis-Philippe, Zhang, Yiming, Yung, Andrew C., Kass, Jennifer, Bohnet, Barry, Yang, Yi, Gopaul, Rayshad, Kozlowski, Piotr, MacVicar, Brian A., Snutch, Terrance P.
Publicado 2022

Chronic pregabalin treatment protects against spreading depolarization and alters hippocampal synaptic characteristics in a model of familial hemiplegic migraine-type 1

por Cain, Stuart M., Alles, Sascha R. A., Gopaul, Ray, Bernier, Louis-Philippe, Yung, Andrew C., Bauman, Andrew, Yang, Yi, Baker, Glen B., Kozlowski, Piotr, MacVicar, Brian A., Snutch, Terrance P.
Publicado 2023

The type 1 cannabinoid receptor positive allosteric modulators GAT591 and GAT593 reduce spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg

por McElroy, Dan L., Roebuck, Andrew J., Greba, Quentin, Garai, Sumanta, Brandt, Asher L., Yilmaz, Orhan, Cain, Stuart M., Snutch, Terrance P., Thakur, Ganesh A., Laprairie, Robert B., Howland, John G.
Publicado 2022

Image-Based Dosimetry in Dogs and Cross-Reactivity with Human Tissues of IGF2R-Targeting Human Antibody

por Allen, Kevin J. H., Kwon, Ohyun, Hutcheson, Matthew R., Grudzinski, Joseph J., Cain, Stuart M., Cruz, Frederic A., Vinayakamoorthy, Remitha M., Sun, Ying S., Fairley, Lindsay, Prabaharan, Chandra B., Dickinson, Ryan, MacDonald-Dickinson, Valerie, Uppalapati, Maruti, Bednarz, Bryan P., Dadachova, Ekaterina
Publicado 2023

Ca(V)3.2 drives sustained burst‐firing, which is critical for absence seizure propagation in reticular thalamic neurons

por Cain, Stuart M., Tyson, John R., Choi, Hyun‐Beom, Ko, Rebecca, Lin, Paulo J. C., LeDue, Jeffrey M., Powell, Kim L., Bernier, Louis‐Philippe, Rungta, Ravi L., Yang, Yi, Cullis, Pieter R., O'Brien, Terence J., MacVicar, Brian A., Snutch, Terrance P.
Publicado 2018