A Prototypical Small-Molecule Modulator Uncouples Mitochondria in Response to Endogenous Hydrogen Peroxide Production

por McQuaker, Stephen J, Quinlan, Casey L, Caldwell, Stuart T, Brand, Martin D, Hartley, Richard C
Publicado 2013

Synthesis of an azido-tagged low affinity ratiometric calcium sensor

por Caldwell, Stuart T., Cairns, Andrew G., Olson, Marnie, Chalmers, Susan, Sandison, Mairi, Mullen, William, McCarron, John G., Hartley, Richard C.
Publicado 2015

Photoactivated release of membrane impermeant sulfonates inside cells

por Caldwell, Stuart T., O'Byrne, Sean N., Wilson, Calum, Cvetko, Filip, Murphy, Michael P., McCarron, John G., Hartley, Richard C.
Publicado 2021

A sensitive mass spectrometric assay for mitochondrial CoQ pool redox state in vivo

por Burger, Nils, Logan, Angela, Prime, Tracy A., Mottahedin, Amin, Caldwell, Stuart T., Krieg, Thomas, Hartley, Richard C., James, Andrew M., Murphy, Michael P.
Publicado 2020

Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production

por Cvetko, Filip, Caldwell, Stuart T., Higgins, Maureen, Suzuki, Takafumi, Yamamoto, Masayuki, Prag, Hiran A., Hartley, Richard C., Dinkova-Kostova, Albena T., Murphy, Michael P.
Publicado 2020

Methionine sulfoxide reductase B3 requires resolving cysteine residues for full activity and can act as a stereospecific methionine oxidase

por Cao, Zhenbo, Mitchell, Lorna, Hsia, Oliver, Scarpa, Miriam, Caldwell, Stuart T., Alfred, Arina D., Gennaris, Alexandra, Collet, Jean-François, Hartley, Richard C., Bulleid, Neil J.
Publicado 2018

Selective Uncoupling of Individual Mitochondria within a Cell Using a Mitochondria-Targeted Photoactivated Protonophore

por Chalmers, Susan, Caldwell, Stuart T., Quin, Caroline, Prime, Tracy A., James, Andrew M., Cairns, Andrew G., Murphy, Michael P., McCarron, John G., Hartley, Richard C.
Publicado 2011

Enhancing the Mitochondrial Uptake of Phosphonium Cations by Carboxylic Acid Incorporation

por Pala, Laura, Senn, Hans M., Caldwell, Stuart T., Prime, Tracy A., Warrington, Stefan, Bright, Thomas P., Prag, Hiran A., Wilson, Claire, Murphy, Michael P., Hartley, Richard C.
Publicado 2020

Selective Delivery of Dicarboxylates to Mitochondria by Conjugation to a Lipophilic Cation via a Cleavable Linker

por Prag, Hiran A., Kula-Alwar, Duvaraka, Pala, Laura, Caldwell, Stuart T., Beach, Timothy E., James, Andrew M., Saeb-Parsy, Kourosh, Krieg, Thomas, Hartley, Richard C., Murphy, Michael P.
Publicado 2020

Tetra-arylborate lipophilic anions as targeting groups

por Gaddale Devanna, Kishore K., Gawel, Justyna M., Prime, Tracy A., Cvetko, Filip, Benincá, Cristiane, Caldwell, Stuart T., Negoda, Alexander, Harrison, Andrew, James, Andrew M., Pavlov, Evgeny V., Murphy, Michael P., Hartley, Richard C.
Publicado 2021

Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation

por Fazakerley, Daniel J., Minard, Annabel Y., Krycer, James R., Thomas, Kristen C., Stöckli, Jacqueline, Harney, Dylan. J., Burchfield, James G., Maghzal, Ghassan J., Caldwell, Stuart T., Hartley, Richard C., Stocker, Roland, Murphy, Michael P., James, David E.
Publicado 2018

Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis

por Antonucci, Salvatore, Mulvey, John F., Burger, Nils, Di Sante, Moises, Hall, Andrew R., Hinchy, Elizabeth C., Caldwell, Stuart T., Gruszczyk, Anja V., Deshwal, Soni, Hartley, Richard C., Kaludercic, Nina, Murphy, Michael P., Di Lisa, Fabio, Krieg, Thomas
Publicado 2019

The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart

por Tate, Mitchel, Higgins, Gavin C., De Blasio, Miles J., Lindblom, Runa, Prakoso, Darnel, Deo, Minh, Kiriazis, Helen, Park, Min, Baeza-Garza, Carlos D., Caldwell, Stuart T., Hartley, Richard C., Krieg, Thomas, Murphy, Michael P., Coughlan, Melinda T., Ritchie, Rebecca H.
Publicado 2019

Targeting Methylglyoxal in Diabetic Kidney Disease Using the Mitochondria-Targeted Compound MitoGamide

por Tan, Sih Min, Lindblom, Runa S. J., Ziemann, Mark, Laskowski, Adrienne, Granata, Cesare, Snelson, Matthew, Thallas-Bonke, Vicki, El-Osta, Assam, Baeza-Garza, Carlos D., Caldwell, Stuart T., Hartley, Richard C., Krieg, Thomas, Cooper, Mark E., Murphy, Michael P., Coughlan, Melinda T.
Publicado 2021

Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo

por Prag, Hiran A., Pala, Laura, Kula-Alwar, Duvaraka, Mulvey, John F., Luping, Du, Beach, Timothy E., Booty, Lee M., Hall, Andrew R., Logan, Angela, Sauchanka, Volha, Caldwell, Stuart T., Robb, Ellen L., James, Andrew M., Xu, Zhelong, Saeb-Parsy, Kourosh, Hartley, Richard C., Murphy, Michael P., Krieg, Thomas
Publicado 2020

Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo

por Booty, Lee M., Gawel, Justyna M., Cvetko, Filip, Caldwell, Stuart T., Hall, Andrew R., Mulvey, John F., James, Andrew M., Hinchy, Elizabeth C., Prime, Tracy A., Arndt, Sabine, Beninca, Cristiane, Bright, Thomas P., Clatworthy, Menna R., Ferdinand, John R., Prag, Hiran A., Logan, Angela, Prudent, Julien, Krieg, Thomas, Hartley, Richard C., Murphy, Michael P.
Publicado 2019

MitoNeoD: A Mitochondria-Targeted Superoxide Probe

por Shchepinova, Maria M., Cairns, Andrew G., Prime, Tracy A., Logan, Angela, James, Andrew M., Hall, Andrew R., Vidoni, Sara, Arndt, Sabine, Caldwell, Stuart T., Prag, Hiran A., Pell, Victoria R., Krieg, Thomas, Mulvey, John F., Yadav, Pooja, Cobley, James N., Bright, Thomas P., Senn, Hans M., Anderson, Robert F., Murphy, Michael P., Hartley, Richard C.
Publicado 2017

Rapid and selective generation of H(2)S within mitochondria protects against cardiac ischemia-reperfusion injury

por Miljkovic, Jan Lj., Burger, Nils, Gawel, Justyna M., Mulvey, John F., Norman, Abigail A.I., Nishimura, Takanori, Tsujihata, Yoshiyuki, Logan, Angela, Sauchanka, Olga, Caldwell, Stuart T., Morris, Jordan L., Prime, Tracy A., Warrington, Stefan, Prudent, Julien, Bates, Georgina R., Aksentijević, Dunja, Prag, Hiran A., James, Andrew M., Krieg, Thomas, Hartley, Richard C., Murphy, Michael P.
Publicado 2022

Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation

por Martin, Jack L., Costa, Ana S. H., Gruszczyk, Anja V., Beach, Timothy E., Allen, Fay M., Prag, Hiran A., Hinchy, Elizabeth C., Mahbubani, Krishnaa, Hamed, Mazin, Tronci, Laura, Nikitopoulou, Efterpi, James, Andrew M., Krieg, Thomas, Robinson, Alan J., Huang, Margaret H., Caldwell, Stuart T., Logan, Angela, Pala, Laura, Hartley, Richard C., Frezza, Christian, Saeb-Parsy, Kourosh, Murphy, Michael P.
Publicado 2019

Confirmation of the Cardioprotective Effect of MitoGamide in the Diabetic Heart

por Park, Min, Nishimura, Takanori, Baeza-Garza, Carlos D., Caldwell, Stuart T., Pun, Pamela Boon Li, Prag, Hiran A., Young, Tim, Sauchanka, Olga, Logan, Angela, Forkink, Marleen, Gruszczyk, Anja V., Prime, Tracy A., Arndt, Sabine, Naudi, Alba, Pamplona, Reinald, Coughlan, Melinda T., Tate, Mitchel, Ritchie, Rebecca H., Caicci, Federico, Kaludercic, Nina, Di Lisa, Fabio, Smith, Robin A. J., Hartley, Richard C., Murphy, Michael P., Krieg, Thomas
Publicado 2020