Impairment of the nerve growth factor pathway driving amyloid accumulation in cholinergic neurons: the incipit of the Alzheimer's disease story?

por Triaca, Viviana, Calissano, Pietro
Publicado 2016

The scientific challenge of the 21(st )century: from a reductionist to a holistic approach via systems biology

por Levi-Montalcini, Rita, Calissano, Pietro
Publicado 2006

A long story for a short peptide: therapeutic efficacy of a cleavage-specific tau antibody

por Amadoro, Giuseppina, Latina, Valentina, Calissano, Pietro
Publicado 2021

Transcriptional Analysis of Apoptotic Cerebellar Granule Neurons Following Rescue by Gastric Inhibitory Polypeptide

por Maino, Barbara, Ciotti, Maria Teresa, Calissano, Pietro, Cavallaro, Sebastiano
Publicado 2014

Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary Neurons

por Latina, Valentina, Caioli, Silvia, Zona, Cristina, Ciotti, Maria T., Amadoro, Giuseppina, Calissano, Pietro
Publicado 2017

Transcriptomic Analysis in the Hippocampus and Retina of Tg2576 AD Mice Reveals Defective Mitochondrial Oxidative Phosphorylation and Recovery by Tau 12A12mAb Treatment

por Morello, Giovanna, Guarnaccia, Maria, La Cognata, Valentina, Latina, Valentina, Calissano, Pietro, Amadoro, Giuseppina, Cavallaro, Sebastiano
Publicado 2023

NGF-Dependent Changes in Ubiquitin Homeostasis Trigger Early Cholinergic Degeneration in Cellular and Animal AD-Model

por Latina, Valentina, Caioli, Silvia, Zona, Cristina, Ciotti, Maria Teresa, Borreca, Antonella, Calissano, Pietro, Amadoro, Giuseppina
Publicado 2018

Nerve Growth Factor-Based Therapy in Alzheimer’s Disease and Age-Related Macular Degeneration

por Amadoro, Giuseppina, Latina, Valentina, Balzamino, Bijorn Omar, Squitti, Rosanna, Varano, Monica, Calissano, Pietro, Micera, Alessandra
Publicado 2021

Y(682)G Mutation of Amyloid Precursor Protein Promotes Endo-Lysosomal Dysfunction by Disrupting APP–SorLA Interaction

por La Rosa, Luca Rosario, Perrone, Lorena, Nielsen, Morten Schallburg, Calissano, Pietro, Andersen, Olav Michael, Matrone, Carmela
Publicado 2015

Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink–parkin pathway

por Amadoro, Giuseppina, Corsetti, Veronica, Florenzano, Fulvio, Atlante, Anna, Bobba, Antonella, Nicolin, Vanessa, Nori, Stefania L., Calissano, Pietro
Publicado 2014

The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer’s Disease Neuropathology

por Canu, Nadia, Amadoro, Giuseppina, Triaca, Viviana, Latina, Valentina, Sposato, Valentina, Corsetti, Veronica, Severini, Cinzia, Ciotti, Maria Teresa, Calissano, Pietro
Publicado 2017

Morphological and biomolecular targets in retina and vitreous from Reelin-deficient mice (Reeler): Potential implications for age-related macular degeneration in Alzheimer’s dement...

por Balzamino, Bijorn Omar, Esposito, Graziana, Marino, Ramona, Calissano, Pietro, Latina, Valentina, Amadoro, Giuseppina, Keller, Flavio, Cacciamani, Andrea, Micera, Alessandra
Publicado 2022

Involvement of Bradykinin Receptor 2 in Nerve Growth Factor Neuroprotective Activity

por Petrella, Carla, Ciotti, Maria Teresa, Nisticò, Robert, Piccinin, Sonia, Calissano, Pietro, Capsoni, Simona, Mercanti, Delio, Cavallaro, Sebastiano, Possenti, Roberta, Severini, Cinzia
Publicado 2020

The Medial Septum Is Insulin Resistant in the AD Presymptomatic Phase: Rescue by Nerve Growth Factor-Driven IRS(1) Activation

por Sposato, Valentina, Canu, Nadia, Fico, Elena, Fusco, Salvatore, Bolasco, Giulia, Ciotti, Maria Teresa, Spinelli, Matteo, Mercanti, Delio, Grassi, Claudio, Triaca, Viviana, Calissano, Pietro
Publicado 2018

Immunotherapy with Cleavage-Specific 12A12mAb Reduces the Tau Cleavage in Visual Cortex and Improves Visuo-Spatial Recognition Memory in Tg2576 AD Mouse Model

por Latina, Valentina, De Introna, Margherita, Caligiuri, Chiara, Loviglio, Alessia, Florio, Rita, La Regina, Federico, Pignataro, Annabella, Ammassari-Teule, Martine, Calissano, Pietro, Amadoro, Giuseppina
Publicado 2023

The Cleavage-Specific Tau 12A12mAb Exerts an Anti-Amyloidogenic Action by Modulating the Endocytic and Bioenergetic Pathways in Alzheimer’s Disease Mouse Model

por Latina, Valentina, Atlante, Anna, Malerba, Francesca, La Regina, Federico, Balzamino, Bijorn Omar, Micera, Alessandra, Pignataro, Annabella, Stigliano, Egidio, Cavallaro, Sebastiano, Calissano, Pietro, Amadoro, Giuseppina
Publicado 2023

MiR-21 is an Ngf-Modulated MicroRNA That Supports Ngf Signaling and Regulates Neuronal Degeneration in PC12 Cells

por Montalban, Enrica, Mattugini, Nicola, Ciarapica, Roberta, Provenzano, Claudia, Savino, Mauro, Scagnoli, Fiorella, Prosperini, Gianluca, Carissimi, Claudia, Fulci, Valerio, Matrone, Carmela, Calissano, Pietro, Nasi, Sergio
Publicado 2014

NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease

por Triaca, Viviana, Sposato, Valentina, Bolasco, Giulia, Ciotti, Maria Teresa, Pelicci, Piergiuseppe, Bruni, Amalia C., Cupidi, Chiara, Maletta, Raffaele, Feligioni, Marco, Nisticò, Robert, Canu, Nadia, Calissano, Pietro
Publicado 2016

hNGF Peptides Elicit the NGF-TrkA Signalling Pathway in Cholinergic Neurons and Retain Full Neurotrophic Activity in the DRG Assay

por Triaca, Viviana, Fico, Elena, Sposato, Valentina, Caioli, Silvia, Ciotti, Maria Teresa, Zona, Cristina, Mercanti, Delio, La Mendola, Diego, Satriano, Cristina, Rizzarelli, Enrico, Tirassa, Paola, Calissano, Pietro
Publicado 2020

Transcriptional Profiles of Cell Fate Transitions Reveal Early Drivers of Neuronal Apoptosis and Survival

por Morello, Giovanna, Villari, Ambra, Spampinato, Antonio Gianmaria, La Cognata, Valentina, Guarnaccia, Maria, Gentile, Giulia, Ciotti, Maria Teresa, Calissano, Pietro, D’Agata, Velia, Severini, Cinzia, Cavallaro, Sebastiano
Publicado 2021