Jointly Modelling Single Nucleotide Polymorphisms With Longitudinal and Time-to-Event Trait: An Application to Type 2 Diabetes and Fasting Plasma Glucose

por Canouil, Mickaël, Balkau, Beverley, Roussel, Ronan, Froguel, Philippe, Rocheleau, Ghislain
Publicado 2018

NACHO: an R package for quality control of NanoString nCounter data

por Canouil, Mickaël, Bouland, Gerard A, Bonnefond, Amélie, Froguel, Philippe, ’t Hart, Leen M, Slieker, Roderick C
Publicado 2019

Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profiles

por Verbanck, Marie, Canouil, Mickaël, Leloire, Audrey, Dhennin, Véronique, Coumoul, Xavier, Yengo, Loïc, Froguel, Philippe, Poulain-Godefroy, Odile
Publicado 2017

Histone deacetylase 9 promoter hypomethylation associated with adipocyte dysfunction is a statin-related metabolic effect

por Khamis, Amna, Boutry, Raphael, Canouil, Mickaël, Mathew, Sumi, Lobbens, Stephane, Crouch, Hutokshi, Andrew, Toby, Abderrahmani, Amar, Tamanini, Filippo, Froguel, Philippe
Publicado 2020

Epigenetic and Transcriptomic Programming of HSC Quiescence Signaling in Large for Gestational Age Neonates

por Pelletier, Alexandre, Carrier, Arnaud, Zhao, Yongmei, Canouil, Mickaël, Derhourhi, Mehdi, Durand, Emmanuelle, Berberian-Ferrato, Lionel, Greally, John, Hughes, Francine, Froguel, Philippe, Bonnefond, Amélie, Delahaye, Fabien
Publicado 2022

Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome

por Canouil, Mickaël, Khamis, Amna, Keikkala, Elina, Hummel, Sandra, Lobbens, Stephane, Bonnefond, Amélie, Delahaye, Fabien, Tzala, Evangelia, Mustaniemi, Sanna, Vääräsmäki, Marja, Jarvelin, Marjo-Riitta, Sebert, Sylvain, Kajantie, Eero, Froguel, Philippe, Andrew, Toby
Publicado 2021

Identification of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed by Natural Variants

por Hegron, Alan, Huh, Eunna, Deupi, Xavier, Sokrat, Badr, Gao, Wenwen, Le Gouill, Christian, Canouil, Mickaël, Boissel, Mathilde, Charpentier, Guillaume, Roussel, Ronan, Balkau, Beverley, Froguel, Philippe, Plouffe, Bianca, Bonnefond, Amélie, Lichtarge, Olivier, Jockers, Ralf, Bouvier, Michel
Publicado 2021

The expression of genes in top obesity-associated loci is enriched in insula and substantia nigra brain regions involved in addiction and reward

por Ndiaye, Fatou K, Huyvaert, Marlène, Ortalli, Ana, Canouil, Mickaël, Lecoeur, Cécile, Verbanck, Marie, Lobbens, Stéphane, Khamis, Amna, Marselli, Lorella, Marchetti, Piero, Kerr-Conte, Julie, Pattou, François, Marre, Michel, Roussel, Ronan, Balkau, Beverley, Froguel, Philippe, Bonnefond, Amélie
Publicado 2019

High morbidity and mortality in children with untreated congenital deficiency of leptin or its receptor

por Saeed, Sadia, Khanam, Roohia, Janjua, Qasim M., Manzoor, Jaida, Ning, Lijiao, Hanook, Sharoon, Canouil, Mickaël, Ali, Muhammad, Ayesha, Hina, Khan, Waqas I., Farooqi, I. Sadaf, Yeo, Giles S.H., O'Rahilly, Stephen, Bonnefond, Amélie, Butt, Taeed A., Arslan, Muhammad, Froguel, Philippe
Publicado 2023

Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach

por Bonnefond, Amélie, Yengo, Loïc, Dechaume, Aurélie, Canouil, Mickaël, Castelain, Maxime, Roger, Estelle, Allegaert, Frédéric, Caiazzo, Robert, Raverdy, Violeta, Pigeyre, Marie, Arredouani, Abdelilah, Borys, Jean-Michel, Lévy-Marchal, Claire, Weill, Jacques, Roussel, Ronan, Balkau, Beverley, Marre, Michel, Pattou, François, Brousseau, Thierry, Froguel, Philippe
Publicado 2017

Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes

por Khamis, Amna, Canouil, Mickaël, Siddiq, Afshan, Crouch, Hutokshi, Falchi, Mario, Bulow, Manon von, Ehehalt, Florian, Marselli, Lorella, Distler, Marius, Richter, Daniela, Weitz, Jürgen, Bokvist, Krister, Xenarios, Ioannis, Thorens, Bernard, Schulte, Anke M., Ibberson, Mark, Bonnefond, Amelie, Marchetti, Piero, Solimena, Michele, Froguel, Philippe
Publicado 2019

Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion

por Hu, Ming, Cebola, Inês, Carrat, Gaelle, Jiang, Shuying, Nawaz, Sameena, Khamis, Amna, Canouil, Mickaël, Froguel, Philippe, Schulte, Anke, Solimena, Michele, Ibberson, Mark, Marchetti, Piero, Cardenas-Diaz, Fabian L., Gadue, Paul J., Hastoy, Benoit, Alemeida-Souza, Leonardo, McMahon, Harvey, Rutter, Guy A.
Publicado 2021

Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion

por Hu, Ming, Cebola, Inês, Carrat, Gaelle, Jiang, Shuying, Nawaz, Sameena, Khamis, Amna, Canouil, Mickaël, Froguel, Philippe, Schulte, Anke, Solimena, Michele, Ibberson, Mark, Marchetti, Piero, Cardenas-Diaz, Fabian L., Gadue, Paul J., Hastoy, Benoit, Almeida-Souza, Leonardo, McMahon, Harvey, Rutter, Guy A.
Publicado 2021

Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion

por Ndiaye, Fatou K., Ortalli, Ana, Canouil, Mickaël, Huyvaert, Marlène, Salazar-Cardozo, Clara, Lecoeur, Cécile, Verbanck, Marie, Pawlowski, Valérie, Boutry, Raphaël, Durand, Emmanuelle, Rabearivelo, Iandry, Sand, Olivier, Marselli, Lorella, Kerr-Conte, Julie, Chandra, Vikash, Scharfmann, Raphaël, Poulain-Godefroy, Odile, Marchetti, Piero, Pattou, François, Abderrahmani, Amar, Froguel, Philippe, Bonnefond, Amélie
Publicado 2017

Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension

por Baron, Morgane, Maillet, Julie, Huyvaert, Marlène, Dechaume, Aurélie, Boutry, Raphaël, Loiselle, Hélène, Durand, Emmanuelle, Toussaint, Bénédicte, Vaillant, Emmanuel, Philippe, Julien, Thomas, Jérémy, Ghulam, Amjad, Franc, Sylvia, Charpentier, Guillaume, Borys, Jean-Michel, Lévy-Marchal, Claire, Tauber, Maïthé, Scharfmann, Raphaël, Weill, Jacques, Aubert, Cécile, Kerr-Conte, Julie, Pattou, François, Roussel, Ronan, Balkau, Beverley, Marre, Michel, Boissel, Mathilde, Derhourhi, Mehdi, Gaget, Stefan, Canouil, Mickaël, Froguel, Philippe, Bonnefond, Amélie
Publicado 2019

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice

por Carrat, Gaelle R., Hu, Ming, Nguyen-Tu, Marie-Sophie, Chabosseau, Pauline, Gaulton, Kyle J., van de Bunt, Martijn, Siddiq, Afshan, Falchi, Mario, Thurner, Matthias, Canouil, Mickaël, Pattou, Francois, Leclerc, Isabelle, Pullen, Timothy J., Cane, Matthew C., Prabhala, Priyanka, Greenwald, William, Schulte, Anke, Marchetti, Piero, Ibberson, Mark, MacDonald, Patrick E., Manning Fox, Jocelyn E., Gloyn, Anna L., Froguel, Philippe, Solimena, Michele, McCarthy, Mark I., Rutter, Guy A.
Publicado 2017

Elevated circulating follistatin associates with an increased risk of type 2 diabetes

por Wu, Chuanyan, Borné, Yan, Gao, Rui, López Rodriguez, Maykel, Roell, William C., Wilson, Jonathan M., Regmi, Ajit, Luan, Cheng, Aly, Dina Mansour, Peter, Andreas, Machann, Jürgen, Staiger, Harald, Fritsche, Andreas, Birkenfeld, Andreas L., Tao, Rongya, Wagner, Robert, Canouil, Mickaël, Hong, Mun-Gwan, Schwenk, Jochen M., Ahlqvist, Emma, Kaikkonen, Minna U., Nilsson, Peter, Shore, Angela C., Khan, Faisel, Natali, Andrea, Melander, Olle, Orho-Melander, Marju, Nilsson, Jan, Häring, Hans-Ulrich, Renström, Erik, Wollheim, Claes B., Engström, Gunnar, Weng, Jianping, Pearson, Ewan R., Franks, Paul W., White, Morris F., Duffin, Kevin L., Vaag, Allan Arthur, Laakso, Markku, Stefan, Norbert, Groop, Leif, De Marinis, Yang
Publicado 2021

Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals

por Liu, Ching-Ti, Merino, Jordi, Rybin, Denis, DiCorpo, Daniel, Benke, Kelly S., Bragg-Gresham, Jennifer L., Canouil, Mickaël, Corre, Tanguy, Grallert, Harald, Isaacs, Aaron, Kutalik, Zoltan, Lahti, Jari, Marullo, Letizia, Marzi, Carola, Rasmussen-Torvik, Laura J., Rocheleau, Ghislain, Rueedi, Rico, Scapoli, Chiara, Verweij, Niek, Vogelzangs, Nicole, Willems, Sara M., Yengo, Loïc, Bakker, Stephan J. L., Beilby, John, Hui, Jennie, Kajantie, Eero, Müller-Nurasyid, Martina, Rathmann, Wolfgang, Balkau, Beverley, Bergmann, Sven, Eriksson, Johan G., Florez, Jose C., Froguel, Philippe, Harris, Tamara, Hung, Joseph, James, Alan L., Kavousi, Maryam, Miljkovic, Iva, Musk, Arthur W., Palmer, Lyle J., Peters, Annette, Roussel, Ronan, van der harst, Pim, van Duijn, Cornelia M., Vollenweider, Peter, Barroso, Inês, Prokopenko, Inga, Dupuis, Josée, Meigs, James B., Bouatia-Naji, Nabila
Publicado 2019

Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies

por Tobi, Elmar W., Juvinao-Quintero, Diana L., Ronkainen, Justiina, Ott, Raffael, Alfano, Rossella, Canouil, Mickaël, Geurtsen, Madelon L., Khamis, Amna, Küpers, Leanne K., Lim, Ives Y., Perron, Patrice, Pesce, Giancarlo, Tuhkanen, Johanna, Starling, Anne P., Andrew, Toby, Binder, Elisabeth, Caiazzo, Robert, Chan, Jerry K.Y., Gaillard, Romy, Gluckman, Peter D., Keikkala, Elina, Karnani, Neerja, Mustaniemi, Sanna, Nawrot, Tim S., Pattou, François, Plusquin, Michelle, Raverdy, Violeta, Tan, Kok Hian, Tzala, Evangelia, Raikkonen, Katri, Winkler, Christiane, Ziegler, Anette-G., Annesi-Maesano, Isabella, Bouchard, Luigi, Chong, Yap Seng, Dabelea, Dana, Felix, Janine F., Heude, Barbara, Jaddoe, Vincent W.V., Lahti, Jari, Reimann, Brigitte, Vääräsmäki, Marja, Bonnefond, Amélie, Froguel, Philippe, Hummel, Sandra, Kajantie, Eero, Jarvelin, Marjo-Riita, Steegers-Theunissen, Regine P.M., Howe, Caitlin G., Hivert, Marie-France, Sebert, Sylvain
Publicado 2022

Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study

por Wesolowska-Andersen, Agata, Brorsson, Caroline A., Bizzotto, Roberto, Mari, Andrea, Tura, Andrea, Koivula, Robert, Mahajan, Anubha, Vinuela, Ana, Tajes, Juan Fernandez, Sharma, Sapna, Haid, Mark, Prehn, Cornelia, Artati, Anna, Hong, Mun-Gwan, Musholt, Petra B., Kurbasic, Azra, De Masi, Federico, Tsirigos, Kostas, Pedersen, Helle Krogh, Gudmundsdottir, Valborg, Thomas, Cecilia Engel, Banasik, Karina, Jennison, Chrisopher, Jones, Angus, Kennedy, Gwen, Bell, Jimmy, Thomas, Louise, Frost, Gary, Thomsen, Henrik, Allin, Kristine, Hansen, Tue Haldor, Vestergaard, Henrik, Hansen, Torben, Rutters, Femke, Elders, Petra, t’Hart, Leen, Bonnefond, Amelie, Canouil, Mickaël, Brage, Soren, Kokkola, Tarja, Heggie, Alison, McEvoy, Donna, Hattersley, Andrew, McDonald, Timothy, Teare, Harriet, Ridderstrale, Martin, Walker, Mark, Forgie, Ian, Giordano, Giuseppe N., Froguel, Philippe, Pavo, Imre, Ruetten, Hartmut, Pedersen, Oluf, Dermitzakis, Emmanouil, Franks, Paul W., Schwenk, Jochen M., Adamski, Jerzy, Pearson, Ewan, McCarthy, Mark I., Brunak, Søren
Publicado 2022