GCKIII kinases in lipotoxicity: Roles in NAFLD and beyond

por Mahlapuu, Margit, Caputo, Mara, Xia, Ying, Cansby, Emmelie
Publicado 2022

Protein kinase STK25 aggravates the severity of non-alcoholic fatty pancreas disease in mice

por Nuñez-Durán, Esther, Chanclón, Belén, Sütt, Silva, Real, Joana, Marschall, Hanns-Ulrich, Wernstedt Asterholm, Ingrid, Cansby, Emmelie, Mahlapuu, Margit
Publicado 2017

Antagonizing STK25 Signaling Suppresses the Development of Hepatocellular Carcinoma Through Targeting Metabolic, Inflammatory, and Pro-Oncogenic Pathways

por Kurhe, Yeshwant, Caputo, Mara, Cansby, Emmelie, Xia, Ying, Kumari, Sima, Anand, Sumit Kumar, Howell, Brian W., Marschall, Hanns-Ulrich, Mahlapuu, Margit
Publicado 2021

STE20-type kinase TAOK3 regulates hepatic lipid partitioning

por Xia, Ying, Caputo, Mara, Cansby, Emmelie, Anand, Sumit Kumar, Sütt, Silva, Henricsson, Marcus, Porosk, Rando, Marschall, Hanns-Ulrich, Blüher, Matthias, Mahlapuu, Margit
Publicado 2021

STE20‐Type Protein Kinase MST4 Controls NAFLD Progression by Regulating Lipid Droplet Dynamics and Metabolic Stress in Hepatocytes

por Caputo, Mara, Cansby, Emmelie, Kumari, Sima, Kurhe, Yeshwant, Nair, Syam, Ståhlman, Marcus, Kulkarni, Nagaraj M., Borén, Jan, Marschall, Hanns‐Ulrich, Blüher, Matthias, Mahlapuu, Margit
Publicado 2021

Silencing of STE20-type kinase TAOK1 confers protection against hepatocellular lipotoxicity through metabolic rewiring

por Xia, Ying, Andersson, Emma, Anand, Sumit K., Cansby, Emmelie, Caputo, Mara, Kumari, Sima, Porosk, Rando, Kilk, Kalle, Nair, Syam, Marschall, Hanns-Ulrich, Blüher, Matthias, Mahlapuu, Margit
Publicado 2023

Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease

por Cansby, Emmelie, Nuñez-Durán, Esther, Magnusson, Elin, Amrutkar, Manoj, Booten, Sheri L., Kulkarni, Nagaraj M., Svensson, L. Thomas, Borén, Jan, Marschall, Hanns-Ulrich, Aghajan, Mariam, Mahlapuu, Margit
Publicado 2018

Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal muscle

por Chursa, Urszula, Nuñez-Durán, Esther, Cansby, Emmelie, Amrutkar, Manoj, Sütt, Silva, Ståhlman, Marcus, Olsson, Britt-Marie, Borén, Jan, Johansson, Maria E., Bäckhed, Fredrik, Johansson, Bengt R., Sihlbom, Carina, Mahlapuu, Margit
Publicado 2016

Knockout of STE20-type kinase TAOK3 does not attenuate diet-induced NAFLD development in mice

por Xia, Ying, Andersson, Emma, Caputo, Mara, Cansby, Emmelie, Sedda, Francesca, Font-Gironès, Ferran, Ruud, Johan, Kurhe, Yeshwant, Hallberg, Bengt, Marschall, Hanns-Ulrich, Asterholm, Ingrid Wernstedt, Romeo, Stefano, Blüher, Matthias, Mahlapuu, Margit
Publicado 2023

Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model

por Amrutkar, Manoj, Cansby, Emmelie, Chursa, Urszula, Nuñez-Durán, Esther, Chanclón, Belén, Ståhlman, Marcus, Fridén, Vincent, Mannerås-Holm, Louise, Wickman, Anna, Smith, Ulf, Bäckhed, Fredrik, Borén, Jan, Howell, Brian W., Mahlapuu, Margit
Publicado 2015

Serine/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in mice

por Nuñez‐Durán, Esther, Aghajan, Mariam, Amrutkar, Manoj, Sütt, Silva, Cansby, Emmelie, Booten, Sheri L., Watt, Andrew, Ståhlman, Marcus, Stefan, Norbert, Häring, Hans‐Ulrich, Staiger, Harald, Borén, Jan, Marschall, Hanns‐Ulrich, Mahlapuu, Margit
Publicado 2017

Inhibition of MAP4K4 signaling initiates metabolic reprogramming to protect hepatocytes from lipotoxic damage

por Anand, Sumit Kumar, Caputo, Mara, Xia, Ying, Andersson, Emma, Cansby, Emmelie, Kumari, Sima, Henricsson, Marcus, Porosk, Rando, Keuenhof, Katharina Susanne, Höög, Johanna Louise, Nair, Syam, Marschall, Hanns-Ulrich, Blüher, Matthias, Mahlapuu, Margit
Publicado 2022

Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease

por Cansby, Emmelie, Caputo, Mara, Gao, Lei, Kulkarni, Nagaraj M., Nerstedt, Annika, Ståhlman, Marcus, Borén, Jan, Porosk, Rando, Soomets, Ursel, Pedrelli, Matteo, Parini, Paolo, Marschall, Hanns-Ulrich, Nyström, Jenny, Howell, Brian W., Mahlapuu, Margit
Publicado 2020

Silencing of STE20-type kinase STK25 in human aortic endothelial and smooth muscle cells is atheroprotective

por Cansby, Emmelie, Kumari, Sima, Caputo, Mara, Xia, Ying, Porosk, Rando, Robinson, Jonathan, Wang, Hao, Olsson, Britt-Marie, Vallin, Josefine, Grantham, Julie, Soomets, Ursel, Svensson, L. Thomas, Sihlbom, Carina, Marschall, Hanns-Ulrich, Edsfeldt, Andreas, Goncalves, Isabel, Mahlapuu, Margit
Publicado 2022