Clinical enrollment assay to detect preexisting neutralizing antibodies to AAV6 with demonstrated transgene expression in gene therapy trials

por Cao, Liching, Ledeboer, Annemarie, Pan, Yonghua, Lu, Yanmei, Meyer, Kathleen
Publicado 2022

A sensitive AAV transduction inhibition assay assists evaluation of critical factors for detection and concordance of pre-existing antibodies

por Pan, Yonghua, Rohde, Michelle, Zeitler, Jennifer, Namburi, Sai Valli Srujana, Cao, Liching, Hu, Jing, Meyer, Kathleen, Lu, Yanmei
Publicado 2023

AAV2/6 Gene Therapy in a Murine Model of Fabry Disease Results in Supraphysiological Enzyme Activity and Effective Substrate Reduction

por Yasuda, Makiko, Huston, Marshall W., Pagant, Silvere, Gan, Lin, St. Martin, Susan, Sproul, Scott, Richards, Daniel, Ballaron, Stephen, Hettini, Khaled, Ledeboer, Annemarie, Falese, Lillian, Cao, Liching, Lu, Yanmei, Holmes, Michael C., Meyer, Kathleen, Desnick, Robert J., Wechsler, Thomas
Publicado 2020