A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention

por Kwon, Young D., Asokan, Mangaiarkarasi, Gorman, Jason, Zhang, Baoshan, Liu, Qingbo, Louder, Mark K., Lin, Bob C., McKee, Krisha, Pegu, Amarendra, Verardi, Raffaello, Yang, Eun Sung, Program, VRC Production, Carlton, Kevin, Doria-Rose, Nicole A., Lusso, Paolo, Mascola, John R., Kwong, Peter D.
Publicado 2021

Assessing the safety and pharmacokinetics of the anti-HIV monoclonal antibody CAP256V2LS alone and in combination with VRC07-523LS and PGT121 in South African women: study protocol...

por Mahomed, Sharana, Garrett, Nigel, Karim, Quarraisha A, Zuma, Nonhlanhla Y, Capparelli, Edmund, Baxter, Cheryl, Gengiah, Tanuja, Archary, Derseree, Samsunder, Natasha, Doria-Rose, Nicole, Moore, Penny, Williamson, Carolyn, Barouch, Dan H, Fast, Patricia E, Pozzetto, Bruno, Hankins, Catherine, Carlton, Kevin, Ledgerwood, Julie, Morris, Lynn, Mascola, John, Abdool Karim, Salim
Publicado 2020

Tyrosine O-sulfation proteoforms affect HIV-1 monoclonal antibody potency

por Cai, Cindy X., Doria-Rose, Nicole A., Schneck, Nicole A., Ivleva, Vera B., Tippett, Brad, Shadrick, William R., O’Connell, Sarah, Cooper, Jonathan W., Schneiderman, Zachary, Zhang, Baoshan, Gowetski, Daniel B., Blackstock, Daniel, Demirji, Jacob, Lin, Bob C., Gorman, Jason, Liu, Tracy, Li, Yile, McDermott, Adrian B., Kwong, Peter D., Carlton, Kevin, Gall, Jason G., Lei, Q. Paula
Publicado 2022

Safety and Pharmacokinetics of Monoclonal Antibodies VRC07-523LS and PGT121 Administered Subcutaneously for Human Immunodeficiency Virus Prevention

por Mahomed, Sharana, Garrett, Nigel, Capparelli, Edmund V, Osman, Farzana, Harkoo, Ishana, Yende-Zuma, Nonhlanhla, Gengiah, Tanuja N, Archary, Derseree, Samsunder, Natasha, Baxter, Cheryl, Mkhize, Nonhlanhla N, Modise, Tandile, Carlton, Kevin, McDermott, Adrian, Moore, Penny L, Karim, Quarraisha Abdool, Barouch, Dan H, Fast, Patricia E, Mascola, John R, Ledgerwood, Julie E, Morris, Lynn, Abdool Karim, Salim S
Publicado 2022

Extended safety and tolerability of subcutaneous CAP256V2LS and VRC07-523LS in HIV-negative women: study protocol for the randomised, placebo-controlled double-blinded, phase 2 CAP...

por Mahomed, Sharana, Garrett, Nigel, Potloane, Disebo, Sikazwe, Izukanji T, Capparelli, Edmund, Harkoo, Ishana, Gengiah, Tanuja Narayansamy, Zuma, Nonhlanhla Yende, Osman, Farzana, Mansoor, Leila, Archary, Derseree, Myeni, Nqobile, Radebe, Precious, Samsunder, Natasha, Doria-Rose, Nicole, Carlton, Kevin, Gama, Lucio, Koup, Richard A, Narpala, Sandeep, Serebryannyy, Leonid, Moore, Penny, Williamson, Carolyn, Pozzetto, Bruno, Hankins, Catherine, Morris, Lynn, Karim, Quarraisha Abdool, Abdool Karim, Salim
Publicado 2023

Bispecific antibody CAP256.J3LS targets V2-apex and CD4-binding sites with high breadth and potency

por Zhang, Baoshan, Gorman, Jason, Kwon, Young D., Pegu, Amarendra, Chao, Cara W., Liu, Tracy, Asokan, Mangaiarkarasi, Bender, Michael F., Bylund, Tatsiana, Damron, Leland, Gollapudi, Deepika, Lei, Paula, Li, Yile, Liu, Cuiping, Louder, Mark K., McKee, Krisha, Olia, Adam S., Rawi, Reda, Schön, Arne, Wang, Shuishu, Yang, Eun Sung, Yang, Yongping, Carlton, Kevin, Doria-Rose, Nicole A., Shapiro, Lawrence, Seaman, Michael S., Mascola, John R., Kwong, Peter D.
Publicado 2023

Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: A Phase 1 open-label clinical trial in healthy adults

por Gaudinski, Martin R., Coates, Emily E., Houser, Katherine V., Chen, Grace L., Yamshchikov, Galina, Saunders, Jamie G., Holman, LaSonji A., Gordon, Ingelise, Plummer, Sarah, Hendel, Cynthia S., Conan-Cibotti, Michelle, Lorenzo, Margarita Gomez, Sitar, Sandra, Carlton, Kevin, Laurencot, Carolyn, Bailer, Robert T., Narpala, Sandeep, McDermott, Adrian B., Namboodiri, Aryan M., Pandey, Janardan P., Schwartz, Richard M., Hu, Zonghui, Koup, Richard A., Capparelli, Edmund, Graham, Barney S., Mascola, John R., Ledgerwood, Julie E.
Publicado 2018

Engineering of HIV-1 neutralizing antibody CAP256V2LS for manufacturability and improved half life

por Zhang, Baoshan, Gollapudi, Deepika, Gorman, Jason, O’Dell, Sijy, Damron, Leland F., McKee, Krisha, Asokan, Mangaiarkarasi, Yang, Eun Sung, Pegu, Amarendra, Lin, Bob C., Chao, Cara W., Chen, Xuejun, Gama, Lucio, Ivleva, Vera B., Law, William H., Liu, Cuiping, Louder, Mark K., Schmidt, Stephen D., Shen, Chen-Hsiang, Shi, Wei, Stein, Judith A., Seaman, Michael S., McDermott, Adrian B., Carlton, Kevin, Mascola, John R., Kwong, Peter D., Lei, Q. Paula, Doria-Rose, Nicole A.
Publicado 2022

Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial

por Houser, Katherine V., Chen, Grace L., Carter, Cristina, Crank, Michelle C., Nguyen, Thuy A., Burgos Florez, Maria Claudia, Berkowitz, Nina M., Mendoza, Floreliz, Hendel, Cynthia Starr, Gordon, Ingelise J., Coates, Emily E., Vazquez, Sandra, Stein, Judy, Case, Christopher L., Lawlor, Heather, Carlton, Kevin, Gaudinski, Martin R., Strom, Larisa, Hofstetter, Amelia R., Liang, C. Jason, Narpala, Sandeep, Hatcher, Christian, Gillespie, Rebecca A., Creanga, Adrian, Kanekiyo, Masaru, Raab, Julie E., Andrews, Sarah F., Zhang, Yi, Yang, Eun Sung, Wang, Lingshu, Leung, Kwanyee, Kong, Wing-Pui, Freyn, Alec W., Nachbagauer, Raffael, Palese, Peter, Bailer, Robert T., McDermott, Adrian B., Koup, Richard A., Gall, Jason G., Arnold, Frank, Mascola, John R., Graham, Barney S., Ledgerwood, Julie E.
Publicado 2022

Safety and immunogenicity of an HIV-1 prefusion-stabilized envelope trimer (Trimer 4571) vaccine in healthy adults: A first-in-human open-label, randomized, dose-escalation, phase...

por Houser, Katherine V., Gaudinski, Martin R., Happe, Myra, Narpala, Sandeep, Verardi, Raffaello, Sarfo, Edward K., Corrigan, Angela R., Wu, Richard, Rothwell, Ro Shauna, Novik, Laura, Hendel, Cynthia S., Gordon, Ingelise J., Berkowitz, Nina M., Cartagena, Cora Trelles, Widge, Alicia T., Coates, Emily E., Strom, Larisa, Hickman, Somia, Conan-Cibotti, Michelle, Vazquez, Sandra, Trofymenko, Olga, Plummer, Sarah, Stein, Judy, Case, Christopher L., Nason, Martha, Biju, Andrea, Parchment, Danealle K., Changela, Anita, Cheng, Cheng, Duan, Hongying, Geng, Hui, Teng, I-Ting, Zhou, Tongqing, O'Connell, Sarah, Barry, Chris, Carlton, Kevin, Gall, Jason G., Flach, Britta, Doria-Rose, Nicole A., Graham, Barney S., Koup, Richard A., McDermott, Adrian B., Mascola, John R., Kwong, Peter D., Ledgerwood, Julie E.
Publicado 2022

Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants

por Pegu, Amarendra, O’Connell, Sarah E., Schmidt, Stephen D., O’Dell, Sijy, Talana, Chloe A., Lai, Lilin, Albert, Jim, Anderson, Evan, Bennett, Hamilton, Corbett, Kizzmekia S., Flach, Britta, Jackson, Lisa, Leav, Brett, Ledgerwood, Julie E., Luke, Catherine J., Makowski, Mat, Nason, Martha C., Roberts, Paul C., Roederer, Mario, Rebolledo, Paulina A., Rostad, Christina A., Rouphael, Nadine G., Shi, Wei, Wang, Lingshu, Widge, Alicia T., Yang, Eun Sung, Beigel, John H., Graham, Barney S., Mascola, John R., Suthar, Mehul S., McDermott, Adrian B., Doria-Rose, Nicole A., Arega, Jae, Beigel, John H., Buchanan, Wendy, Elsafy, Mohammed, Hoang, Binh, Lampley, Rebecca, Kolhekar, Aparna, Koo, Hyung, Luke, Catherine, Makhene, Mamodikoe, Nayak, Seema, Pikaart-Tautges, Rhonda, Roberts, Paul C., Russell, Janie, Sindall, Elisa, Albert, Jim, Kunwar, Pratap, Makowski, Mat, Anderson, Evan J., Bechnak, Amer, Bower, Mary, Camacho-Gonzalez, Andres F., Collins, Matthew, Drobeniuc, Ana, Edara, Venkata Viswanadh, Edupuganti, Srilatha, Floyd, Katharine, Gibson, Theda, Ackerley, Cassie M. Grimsley, Johnson, Brandi, Kamidani, Satoshi, Kao, Carol, Kelley, Colleen, Lai, Lilin, Macenczak, Hollie, McCullough, Michele Paine, Peters, Etza, Phadke, Varun K., Rebolledo, Paulina A., Rostad, Christina A., Rouphael, Nadine, Scherer, Erin, Sherman, Amy, Stephens, Kathy, Suthar, Mehul S., Teherani, Mehgan, Traenkner, Jessica, Winston, Juton, Yildirim, Inci, Barr, Lee, Benoit, Joyce, Carste, Barbara, Choe, Joe, Dunstan, Maya, Erolin, Roxanne, ffitch, Jana, Fields, Colin, Jackson, Lisa A., Kiniry, Erika, Lasicka, Susan, Lee, Stella, Nguyen, Matthew, Pimienta, Stephanie, Suyehira, Janice, Witte, Michael, Bennett, Hamilton, Altaras, Nedim Emil, Carfi, Andrea, Hurley, Marjorie, Leav, Brett, Pajon, Rolando, Sun, Wellington, Zaks, Tal, Coler, Rhea N., Larsen, Sasha E., Neuzil, Kathleen M., Lindesmith, Lisa C., Martinez, David R., Munt, Jennifer, Mallory, Michael, Edwards, Caitlin, Baric, Ralph S., Berkowitz, Nina M., Boritz, Eli A., Carlton, Kevin, Corbett, Kizzmekia S., Costner, Pamela, Creanga, Adrian, Doria-Rose, Nicole A., Douek, Daniel C., Flach, Britta, Gaudinski, Martin, Gordon, Ingelise, Graham, Barney S., Holman, LaSonji, Ledgerwood, Julie E., Leung, Kwanyee, Lin, Bob C., Louder, Mark K., Mascola, John R., McDermott, Adrian B., Morabito, Kaitlyn M., Novik, Laura, O’Connell, Sarah, O’Dell, Sijy, Padilla, Marcelino, Pegu, Amarendra, Schmidt, Stephen D., Shi, Wei, Swanson, Phillip A., Talana, Chloe A., Wang, Lingshu, Widge, Alicia T., Yang, Eun Sung, Zhang, Yi, Chappell, James D., Denison, Mark R., Hughes, Tia, Lu, Xiaotao, Pruijssers, Andrea J., Stevens, Laura J., Posavad, Christine M., Gale, Michael, Menachery, Vineet, Shi, Pei-Yong
Publicado 2021