Overcoming the challenges of membrane protein crystallography

por Carpenter, Elisabeth P, Beis, Konstantinos, Cameron, Alexander D, Iwata, So
Publicado 2008

Mammalian Glucose Transporter Activity Is Dependent upon Anionic and Conical Phospholipids

por Hresko, Richard C., Kraft, Thomas E., Quigley, Andrew, Carpenter, Elisabeth P., Hruz, Paul W.
Publicado 2016

An overview of heavy-atom derivatization of protein crystals

por Pike, Ashley C. W., Garman, Elspeth F., Krojer, Tobias, von Delft, Frank, Carpenter, Elisabeth P.
Publicado 2016

Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states

por McClenaghan, Conor, Schewe, Marcus, Aryal, Prafulla, Carpenter, Elisabeth P., Baukrowitz, Thomas, Tucker, Stephen J.
Publicado 2016

ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability

por Spear, Eric D., Hsu, Erh-Ting, Nie, Laiyin, Carpenter, Elisabeth P., Hrycyna, Christine A., Michaelis, Susan
Publicado 2018

Site specificity determinants for prelamin A cleavage by the zinc metalloprotease ZMPSTE24

por Babatz, Timothy D., Spear, Eric D., Xu, Wenxin, Sun, Olivia L., Nie, Laiyin, Carpenter, Elisabeth P., Michaelis, Susan
Publicado 2020

Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24

por Mehmood, Shahid, Marcoux, Julien, Gault, Joseph, Quigley, Andrew, Michaelis, Susan, Young, Stephen G., Carpenter, Elisabeth P., Robinson, Carol V.
Publicado 2016

MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes

por Stansfeld, Phillip J., Goose, Joseph E., Caffrey, Martin, Carpenter, Elisabeth P., Parker, Joanne L., Newstead, Simon, Sansom, Mark S.P.
Publicado 2015

Insights into How Nucleotide-Binding Domains Power ABC Transport

por Newstead, Simon, Fowler, Philip W., Bilton, Paul, Carpenter, Elisabeth P., Sadler, Peter J., Campopiano, Dominic J., Sansom, Mark S.P., Iwata, So
Publicado 2009

Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate

por Proks, Peter, Schewe, Marcus, Conrad, Linus J., Rao, Shanlin, Rathje, Kristin, Rödström, Karin E.J., Carpenter, Elisabeth P., Baukrowitz, Thomas, Tucker, Stephen J.
Publicado 2021

Thioredoxin A Active-Site Mutants Form Mixed Disulfide Dimers That Resemble Enzyme–Substrate Reaction Intermediates

por Kouwen, Thijs R.H.M., Andréll, Juni, Schrijver, Rianne, Dubois, Jean-Yves F., Maher, Megan J., Iwata, So, Carpenter, Elisabeth P., van Dijl, Jan Maarten
Publicado 2008

Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2

por Wang, Qinrui, Corey, Robin A., Hedger, George, Aryal, Prafulla, Grieben, Mariana, Nasrallah, Chady, Baronina, Agnese, Pike, Ashley C.W., Shi, Jiye, Carpenter, Elisabeth P., Sansom, Mark S.P.
Publicado 2020

Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation

por Yu, Xiaodi, Plotnikova, Olga, Bonin, Paul D, Subashi, Timothy A, McLellan, Thomas J, Dumlao, Darren, Che, Ye, Dong, Yin Yao, Carpenter, Elisabeth P, West, Graham M, Qiu, Xiayang, Culp, Jeffrey S, Han, Seungil
Publicado 2019

Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel

por Aryal, Prafulla, Jarerattanachat, Viwan, Clausen, Michael V., Schewe, Marcus, McClenaghan, Conor, Argent, Liam, Conrad, Linus J., Dong, Yin Y., Pike, Ashley C.W., Carpenter, Elisabeth P., Baukrowitz, Thomas, Sansom, Mark S.P., Tucker, Stephen J.
Publicado 2017

The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery

por Bradley, Anthony R., Echalier, Aude, Fairhead, Michael, Strain-Damerell, Claire, Brennan, Paul, Bullock, Alex N., Burgess-Brown, Nicola A., Carpenter, Elisabeth P., Gileadi, Opher, Marsden, Brian D., Lee, Wen Hwa, Yue, Wyatt, Bountra, Chas, von Delft, Frank
Publicado 2017

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K

por Bushell, Simon R., Pike, Ashley C. W., Falzone, Maria E., Rorsman, Nils J. G., Ta, Chau M., Corey, Robin A., Newport, Thomas D., Christianson, John C., Scofano, Lara F., Shintre, Chitra A., Tessitore, Annamaria, Chu, Amy, Wang, Qinrui, Shrestha, Leela, Mukhopadhyay, Shubhashish M. M., Love, James D., Burgess-Brown, Nicola A., Sitsapesan, Rebecca, Stansfeld, Phillip J., Huiskonen, Juha T., Tammaro, Paolo, Accardi, Alessio, Carpenter, Elisabeth P.
Publicado 2019

Gain-of-function mutations in KCNK3 cause a developmental disorder with sleep apnea

por Sörmann, Janina, Schewe, Marcus, Proks, Peter, Jouen-Tachoire, Thibault, Rao, Shanlin, Riel, Elena B., Agre, Katherine E., Begtrup, Amber, Dean, John, Descartes, Maria, Fischer, Jan, Gardham, Alice, Lahner, Carrie, Mark, Paul R., Muppidi, Srikanth, Pichurin, Pavel N., Porrmann, Joseph, Schallner, Jens, Smith, Kirstin, Straub, Volker, Vasudevan, Pradeep, Willaert, Rebecca, Carpenter, Elisabeth P., Rödström, Karin E. J., Hahn, Michael G., Müller, Thomas, Baukrowitz, Thomas, Hurles, Matthew E., Wright, Caroline F., Tucker, Stephen J.
Publicado 2022

Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design

por Dong, Yin Yao, Wang, Hua, Pike, Ashley C.W., Cochrane, Stephen A., Hamedzadeh, Sadra, Wyszyński, Filip J., Bushell, Simon R., Royer, Sylvain F., Widdick, David A., Sajid, Andaleeb, Boshoff, Helena I., Park, Yumi, Lucas, Ricardo, Liu, Wei-Min, Lee, Seung Seo, Machida, Takuya, Minall, Leanne, Mehmood, Shahid, Belaya, Katsiaryna, Liu, Wei-Wei, Chu, Amy, Shrestha, Leela, Mukhopadhyay, Shubhashish M.M., Strain-Damerell, Claire, Chalk, Rod, Burgess-Brown, Nicola A., Bibb, Mervyn J., Barry III, Clifton E., Robinson, Carol V., Beeson, David, Davis, Benjamin G., Carpenter, Elisabeth P.
Publicado 2018

Structural and functional diversity calls for a new classification of ABC transporters

por Thomas, Christoph, Aller, Stephen G., Beis, Konstantinos, Carpenter, Elisabeth P., Chang, Geoffrey, Chen, Lei, Dassa, Elie, Dean, Michael, Van Hoa, Franck Duong, Ekiert, Damian, Ford, Robert, Gaudet, Rachelle, Gong, Xin, Holland, I. Barry, Huang, Yihua, Kahne, Daniel K., Kato, Hiroaki, Koronakis, Vassilis, Koth, Christopher M., Lee, Youngsook, Lewinson, Oded, Lill, Roland, Martinoia, Enrico, Murakami, Satoshi, Pinkett, Heather W., Poolman, Bert, Rosenbaum, Daniel, Sarkadi, Balazs, Schmitt, Lutz, Schneider, Erwin, Shi, Yigong, Shyng, Show-Ling, Slotboom, Dirk J., Tajkhorshid, Emad, Tieleman, D. Peter, Ueda, Kazumitsu, Váradi, András, Wen, Po-Chao, Yan, Nieng, Zhang, Peng, Zheng, Hongjin, Zimmer, Jochen, Tampé, Robert
Publicado 2020