Zinc Metallochaperones as Mutant p53 Reactivators: A New Paradigm in Cancer Therapeutics

por Kogan, Samuel, Carpizo, Darren R.
Publicado 2018

Flipping the “switch” on mutant p53 by zinc metallochaperones: how a brief pulse of zinc can reactivate mutant p53 to kill cancer

por Yu, Xin, Carpizo, Darren R.
Publicado 2019

Genetic Drivers of Ileal Neuroendocrine Tumors

por Carpizo, Darren R., Harris, Chris R.
Publicado 2021

Small molecule compounds targeting the p53 pathway: are we finally making progress?

por Yu, Xin, Narayanan, Sumana, Vazquez, Alexei, Carpizo, Darren R.
Publicado 2014

p53 and Zinc: A Malleable Relationship

por Ha, Jeung-Hoi, Prela, Orjola, Carpizo, Darren R., Loh, Stewart N.
Publicado 2022

Repair of a Post-Hepatectomy Posterior Sectoral Duct Injury Secondary to Anomalous Bile Duct Anatomy Using a Novel Combined Surgical-Interventional Radiologic Approach

por Shanker, Beth-Ann, Eng, Oliver S., Gendel, Vyacheslav, Nosher, John, Carpizo, Darren R.
Publicado 2013

Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors

por Lee, Sunyoung, Jilani, Shahla M., Nikolova, Ganka V., Carpizo, Darren, Iruela-Arispe, M. Luisa
Publicado 2005

A novel combined interventional radiologic and hepatobiliary surgical approach to a complex traumatic hilar biliary stricture()

por NeMoyer, Rachel E., Shah, Mihir M., Hasan, Omar, Nosher, John L., Carpizo, Darren R.
Publicado 2018

Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2

por Yue, Wen, Zheng, Xi, Lin, Yong, Yang, Chung S., Xu, Qing, Carpizo, Darren, Huang, Huarong, DiPaola, Robert S., Tan, Xiang-Lin
Publicado 2015

Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism

por Yu, Xin, Blanden, Adam R., Narayanan, Sumana, Jayakumar, Lalithapriya, Lubin, David, Augeri, David, David Kimball, S., Loh, Stewart N., Carpizo, Darren R.
Publicado 2014

Zinc shapes the folding landscape of p53 and establishes a pathway for reactivating structurally diverse cancer mutants

por Blanden, Adam R, Yu, Xin, Blayney, Alan J, Demas, Christopher, Ha, Jeung-Hoi, Liu, Yue, Withers, Tracy, Carpizo, Darren R, Loh, Stewart N
Publicado 2020

Early vs. Late Chemoradiation Therapy and the Postoperative Interval to Adjuvant Therapy Do Not Correspond to Local Recurrence in Resected Pancreatic Cancer

por Patel, Ajay A, Nagarajan, Sairaman, Scher, Eli D, Schonewolf, Caitlin AB, Balasubramanian, Sairam, Poplin, Elizabeth, Moss, Rebecca, August, David, Carpizo, Darren, Melstrom, Laleh, Jabbour, Salma K
Publicado 2015

Therapeutic targeting of BRCA1 and TP53 mutant breast cancer through mutant p53 reactivation

por Na, Bing, Yu, Xin, Withers, Tracy, Gilleran, John, Yao, Ming, Foo, Tzeh Keong, Chen, Chunxia, Moore, Dirk, Lin, Yong, Kimball, S. David, Xia, Bing, Ganesan, Shridar, Carpizo, Darren R.
Publicado 2019

Dose-Painted Intensity Modulated Radiation Therapy Improves Local Control for Locally Advanced Pancreas Cancer

por Tunceroglu, Ahmet, Park, Joo Han, Balasubramanian, Sairam, Poppe, Matthew, Anker, Christopher J., Poplin, Elizabeth, Moss, Rebecca A., Yue, Ning J., Carpizo, Darren, Gannon, Christopher J., Haffty, Bruce G., Jabbour, Salma K.
Publicado 2012

Subcategorizing T1 Staging in Pancreatic Adenocarcinoma Predicts Survival in Patients Undergoing Resection: An Analysis of the National Cancer Database

por Shah, Mihir M., NeMoyer, Rachel E., Greco, Stephanie H., Chen, Chunxia, Moore, Dirk F., Grandhi, Miral S., Langan, Russell C., Kennedy, Timothy J., Javidian, Parisa, Jabbour, Salma K., Alexander, H. Richard, August, David A., Carpizo, Darren R.
Publicado 2020

Neoadjuvant therapy is associated with lower margin positivity rates after Pancreaticoduodenectomy in T1 and T2 pancreatic head cancers: An analysis of the National Cancer Database

por Greco, Stephanie H., August, David A., Shah, Mihir M., Chen, Chunxia, Moore, Dirk F., Masanam, Monika, Turner, Amber L., Jabbour, Salma K., Javidian, Parisa, Grandhi, Miral S., Kennedy, Timothy J., Alexander, H. Richard, Carpizo, Darren R., Langan, Russell C.
Publicado 2020

Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing

por Chiou, Shin-Heng, Winters, Ian P., Wang, Jing, Naranjo, Santiago, Dudgeon, Crissy, Tamburini, Fiona B., Brady, Jennifer J., Yang, Dian, Grüner, Barbara M., Chuang, Chen-Hua, Caswell, Deborah R., Zeng, Hong, Chu, Pauline, Kim, Grace E., Carpizo, Darren R., Kim, Seung K., Winslow, Monte M.
Publicado 2015

Rethinking the Role of Radiation Therapy in the Treatment of Unresectable Hepatocellular Carcinoma: A Data Driven Treatment Algorithm for Optimizing Outcomes

por Sayan, Mutlay, Yegya-Raman, Nikhil, Greco, Stephanie H., Gui, Bin, Zhang, Andrew, Chundury, Anupama, Grandhi, Miral S., Hochster, Howard S., Kennedy, Timothy J., Langan, Russell C., Malhotra, Usha, Rustgi, Vinod K., Shah, Mihir M., Spencer, Kristen R., Carpizo, Darren R., Nosher, John L., Jabbour, Salma K.
Publicado 2019