Quantitative phenotypic and pathway profiling guides rational drug combination strategies

por Dawson, John C., Carragher, Neil O.
Publicado 2014

Palladium-Mediated Dealkylation of N-Propargyl-Floxuridine as a Bioorthogonal Oxygen-Independent Prodrug Strategy

por Weiss, Jason T., Carragher, Neil O., Unciti-Broceta, Asier
Publicado 2015

Development of the Theta Comparative Cell Scoring Method to Quantify Diverse Phenotypic Responses Between Distinct Cell Types

por Warchal, Scott J., Dawson, John C., Carragher, Neil O.
Publicado 2016

Accelerating glioblastoma drug discovery: Convergence of patient-derived models, genome editing and phenotypic screening

por O'Duibhir, Eoghan, Carragher, Neil O., Pollard, Steven M.
Publicado 2016

Evaluation of Machine Learning Classifiers to Predict Compound Mechanism of Action When Transferred across Distinct Cell Lines

por Warchal, Scott J., Dawson, John C., Carragher, Neil O.
Publicado 2019

Degraded Collagen Fragments Promote Rapid Disassembly of Smooth Muscle Focal Adhesions That Correlates with Cleavage of Pp125(FAK), Paxillin, and Talin

por Carragher, Neil O., Levkau, Bodo, Ross, Russell, Raines, Elaine W.
Publicado 1999

Naturally Inspired Peptide Leads: Alanine Scanning Reveals an Actin‐Targeting Thiazole Analogue of Bisebromoamide

por Johnston, Heather J., Boys, Sarah K., Makda, Ashraff, Carragher, Neil O., Hulme, Alison N.
Publicado 2016

A Novel High-Content Phenotypic Screen To Identify Inhibitors of Mitochondrial DNA Maintenance in Trypanosomes

por Miskinyte, Migla, Dawson, John C., Makda, Ashraff, Doughty-Shenton, Dahlia, Carragher, Neil O., Schnaufer, Achim
Publicado 2022

Phenonaut: multiomics data integration for phenotypic space exploration

por Shave, Steven, Dawson, John C, Athar, Abdullah M, Nguyen, Cuong Q, Kasprowicz, Richard, Carragher, Neil O
Publicado 2023

Drug screening in zebrafish larvae reveals inflammation-related modulators of secondary damage after spinal cord injury in mice

por Oprişoreanu, Ana-Maria, Ryan, Fari, Richmond, Claire, Dzekhtsiarova, Yuliya, Carragher, Neil O., Becker, Thomas, David, Samuel, Becker, Catherina G.
Publicado 2023

High content phenotypic screening identifies serotonin receptor modulators with selective activity upon breast cancer cell cycle and cytokine signaling pathways

por Warchal, Scott J., Dawson, John C., Shepherd, Emelie, Munro, Alison F., Hughes, Rebecca E., Makda, Ashraff, Carragher, Neil O.
Publicado 2020

Combined targeting of MEK and the glucocorticoid receptor for the treatment of RAS-mutant multiple myeloma

por Sriskandarajah, Priya, De Haven Brandon, Alexis, MacLeod, Kenneth, Carragher, Neil O., Kirkin, Vladimir, Kaiser, Martin, Whittaker, Steven R.
Publicado 2020

YAP/TAZ activation predicts clinical outcomes in mesothelioma and is conserved in in vitro model of driver mutations

por Cunningham, Richard, Jia, Siyang, Purohit, Krishna, Salem, Omar, Hui, Ning Sze, Lin, Yue, Carragher, Neil O., Hansen, Carsten Gram
Publicado 2023

Glioblastoma and the search for non-hypothesis driven combination therapeutics in academia

por Johanssen, Timothy, McVeigh, Laura, Erridge, Sara, Higgins, Geoffrey, Straehla, Joelle, Frame, Margaret, Aittokallio, Tero, Carragher, Neil O., Ebner, Daniel
Publicado 2023

Live Cell in Vitro and in Vivo Imaging Applications: Accelerating Drug Discovery

por Isherwood, Beverley, Timpson, Paul, McGhee, Ewan J, Anderson, Kurt I, Canel, Marta, Serrels, Alan, Brunton, Valerie G, Carragher, Neil O
Publicado 2011

High-Content Phenotypic Profiling in Esophageal Adenocarcinoma Identifies Selectively Active Pharmacological Classes of Drugs for Repurposing and Chemical Starting Points for Novel...

por Hughes, Rebecca E., Elliott, Richard J. R., Munro, Alison F., Makda, Ashraff, O’Neill, J. Robert, Hupp, Ted, Carragher, Neil O.
Publicado 2020

Application of a High-Content Screening Assay Utilizing Primary Human Lung Fibroblasts to Identify Antifibrotic Drugs for Rapid Repurposing in COVID-19 Patients

por Marwick, John A., Elliott, Richard J.R., Longden, James, Makda, Ashraff, Hirani, Nik, Dhaliwal, Kevin, Dawson, John C., Carragher, Neil O.
Publicado 2021

Automated in vivo drug screen in zebrafish identifies synapse-stabilising drugs with relevance to spinal muscular atrophy

por Opris¸oreanu, Ana-Maria, Smith, Hannah L., Krix, Sophia, Chaytow, Helena, Carragher, Neil O., Gillingwater, Thomas H., Becker, Catherina G., Becker, Thomas
Publicado 2021

Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors for cancer treatment

por Dawson, John C., Munro, Alison, Macleod, Kenneth, Muir, Morwenna, Timpson, Paul, Williams, Robert J., Frame, Margaret, Brunton, Valerie G., Carragher, Neil O.
Publicado 2021

Chemogenomic library design strategies for precision oncology, applied to phenotypic profiling of glioblastoma patient cells

por Athanasiadis, Paschalis, Ravikumar, Balaguru, Elliott, Richard J.R., Dawson, John C., Carragher, Neil O., Clemons, Paul A., Johanssen, Timothy, Ebner, Daniel, Aittokallio, Tero
Publicado 2023