Integrating cell morphology with gene expression and chemical structure to aid mitochondrial toxicity detection

por Seal, Srijit, Carreras-Puigvert, Jordi, Trapotsi, Maria-Anna, Yang, Hongbin, Spjuth, Ola, Bender, Andreas
Publicado 2022

Merging bioactivity predictions from cell morphology and chemical fingerprint models using similarity to training data

por Seal, Srijit, Yang, Hongbin, Trapotsi, Maria-Anna, Singh, Satvik, Carreras-Puigvert, Jordi, Spjuth, Ola, Bender, Andreas
Publicado 2023

A chemical screen for modulators of mRNA translation identifies a distinct mechanism of toxicity for sphingosine kinase inhibitors

por Corman, Alba, Kanellis, Dimitris C., Michalska, Patrycja, Häggblad, Maria, Lafarga, Vanesa, Bartek, Jiri, Carreras-Puigvert, Jordi, Fernandez-Capetillo, Oscar
Publicado 2021

NOX4 regulates TGFβ‐induced proliferation and self‐renewal in glioblastoma stem cells

por García‐Gómez, Pedro, Golán, Irene, S. Dadras, Mahsa, Mezheyeuski, Artur, Bellomo, Claudia, Tzavlaki, Kalliopi, Morén, Anita, Carreras‐Puigvert, Jordi, Caja, Laia
Publicado 2022

Evaluating the utility of brightfield image data for mechanism of action prediction

por Harrison, Philip John, Gupta, Ankit, Rietdijk, Jonne, Wieslander, Håkan, Carreras-Puigvert, Jordi, Georgiev, Polina, Wählby, Carolina, Spjuth, Ola, Sintorn, Ida-Maria
Publicado 2023

High content drug screening for Fanconi anemia therapeutics

por Montanuy, Helena, Camps-Fajol, Cristina, Carreras-Puigvert, Jordi, Häggblad, Maria, Lundgren, Bo, Aza-Carmona, Miriam, Helleday, Thomas, Minguillón, Jordi, Surrallés, Jordi
Publicado 2020

A phenomics approach for antiviral drug discovery

por Rietdijk, Jonne, Tampere, Marianna, Pettke, Aleksandra, Georgiev, Polina, Lapins, Maris, Warpman-Berglund, Ulrika, Spjuth, Ola, Puumalainen, Marjo-Riitta, Carreras-Puigvert, Jordi
Publicado 2021

New regulators of the tetracycline‐inducible gene expression system identified by chemical and genetic screens

por Colicchia, Valeria, Häggblad, Maria, Sirozh, Oleksandra, Porebski, Bartlomiej, Balan, Mirela, Li, Xuexin, Lidemalm, Louise, Carreras‐Puigvert, Jordi, Hühn, Daniela, Fernandez‐Capetillo, Oscar
Publicado 2022

The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity

por Espinoza, Jaime A., Zisi, Asimina, Kanellis, Dimitris C., Carreras-Puigvert, Jordi, Henriksson, Martin, Hühn, Daniela, Watanabe, Kenji, Helleday, Thomas, Lindström, Mikael S., Bartek, Jiri
Publicado 2019

Prolonged estrogen deprivation triggers a broad immunosuppressive phenotype in breast cancer cells

por Hühn, Daniela, Martí‐Rodrigo, Pablo, Mouron, Silvana, Hansel, Catherine, Tschapalda, Kirsten, Porebski, Bartlomiej, Häggblad, Maria, Lidemalm, Louise, Quintela‐Fandino, Miguel, Carreras‐Puigvert, Jordi, Fernandez‐Capetillo, Oscar
Publicado 2021

Development of new approach methods for the identification and characterization of endocrine metabolic disruptors—a PARC project

por Braeuning, Albert, Balaguer, Patrick, Bourguet, William, Carreras-Puigvert, Jordi, Feiertag, Katreece, Kamstra, Jorke H., Knapen, Dries, Lichtenstein, Dajana, Marx-Stoelting, Philip, Rietdijk, Jonne, Schubert, Kristin, Spjuth, Ola, Stinckens, Evelyn, Thedieck, Kathrin, van den Boom, Rik, Vergauwen, Lucia, von Bergen, Martin, Wewer, Neele, Zalko, Daniel
Publicado 2023

A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family

por Carreras-Puigvert, Jordi, Zitnik, Marinka, Jemth, Ann-Sofie, Carter, Megan, Unterlass, Judith E., Hallström, Björn, Loseva, Olga, Karem, Zhir, Calderón-Montaño, José Manuel, Lindskog, Cecilia, Edqvist, Per-Henrik, Matuszewski, Damian J., Ait Blal, Hammou, Berntsson, Ronnie P. A., Häggblad, Maria, Martens, Ulf, Studham, Matthew, Lundgren, Bo, Wählby, Carolina, Sonnhammer, Erik L. L., Lundberg, Emma, Stenmark, Pål, Zupan, Blaz, Helleday, Thomas
Publicado 2017