Novel Quinazolinone Inhibitors of ALK2 Flip between Alternate Binding Modes: Structure–Activity Relationship, Structural Characterization, Kinase Profiling, and Cellular Proof of C...

por Hudson, Liam, Mui, James, Vázquez, Santiago, Carvalho, Diana M., Williams, Eleanor, Jones, Chris, Bullock, Alex N., Hoelder, Swen
Publicado 2018

DDEL-06. Drug Delivery to the Pons Using Short-Pulse Focused Ultrasound and Microbubble Exposure for the Treatment of Diffuse Midline Glioma

por Chattenton, Dani, Rivens, Ian, Jiang, Zheng, Carvalho, Diana M, Sujarittam, Krit, Boult, Jessica K R, Robinson, Simon P, Jones, Chris, ter Haar, Gail, Choi, James
Publicado 2022

Pathogenic ACVR1(R206H) activation by Activin A‐induced receptor clustering and autophosphorylation

por Ramachandran, Anassuya, Mehić, Merima, Wasim, Laabiah, Malinova, Dessislava, Gori, Ilaria, Blaszczyk, Beata K, Carvalho, Diana M, Shore, Eileen M, Jones, Chris, Hyvönen, Marko, Tolar, Pavel, Hill, Caroline S
Publicado 2021

PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma

por Fons, Nathan R., Sundaram, Ranjini K., Breuer, Gregory A., Peng, Sen, McLean, Ryan L., Kalathil, Aravind N., Schmidt, Mark S., Carvalho, Diana M., Mackay, Alan, Jones, Chris, Carcaboso, Ángel M., Nazarian, Javad, Berens, Michael E., Brenner, Charles, Bindra, Ranjit S.
Publicado 2019

Droplet digital PCR-based detection of circulating tumor DNA from pediatric high grade and diffuse midline glioma patients

por Izquierdo, Elisa, Proszek, Paula, Pericoli, Giulia, Temelso, Sara, Clarke, Matthew, Carvalho, Diana M, Mackay, Alan, Marshall, Lynley V, Carceller, Fernando, Hargrave, Darren, Lannering, Birgitta, Pavelka, Zdenek, Bailey, Simon, Entz-Werle, Natacha, Grill, Jacques, Vassal, Gilles, Rodriguez, Daniel, Morgan, Paul S, Jaspan, Tim, Mastronuzzi, Angela, Vinci, Mara, Hubank, Michael, Jones, Chris
Publicado 2021

Repurposing Vandetanib plus Everolimus for the Treatment of ACVR1-Mutant Diffuse Intrinsic Pontine Glioma

por Carvalho, Diana M., Richardson, Peter J., Olaciregui, Nagore, Stankunaite, Reda, Lavarino, Cinzia, Molinari, Valeria, Corley, Elizabeth A., Smith, Daniel P., Ruddle, Ruth, Donovan, Adam, Pal, Akos, Raynaud, Florence I., Temelso, Sara, Mackay, Alan, Overington, John P., Phelan, Anne, Sheppard, David, Mackinnon, Andrew, Zebian, Bassel, Al-Sarraj, Safa, Merve, Ashirwad, Pryce, Jeremy, Grill, Jacques, Hubank, Michael, Cruz, Ofelia, Morales La Madrid, Andres, Mueller, Sabine, Carcaboso, Angel M., Carceller, Fernando, Jones, Chris
Publicado 2022

DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition

por Izquierdo, Elisa, Carvalho, Diana M., Mackay, Alan, Temelso, Sara, Boult, Jessica K.R., Pericoli, Giulia, Fernandez, Elisabet, Das, Molina, Molinari, Valeria, Grabovska, Yura, Rogers, Rebecca F., Ajmone-Cat, Maria Antonietta, Proszek, Paula Z., Stubbs, Mark, Depani, Sarita, O'Hare, Patricia, Yu, Lu, Roumelioti, Georgia, Choudhary, Jyoti S., Clarke, Matthew, Fairchild, Amy R., Jacques, Thomas S., Grundy, Richard G., Howell, Lisa, Picton, Susan, Adamski, Jenny, Wilson, Shaun, Gray, Juliet C., Zebian, Bassel, Marshall, Lynley V., Carceller, Fernando, Grill, Jacques, Vinci, Maria, Robinson, Simon P., Hubank, Michael, Hargrave, Darren, Jones, Chris
Publicado 2022

PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation

por Khadka, Prasidda, Reitman, Zachary J., Lu, Sophie, Buchan, Graham, Gionet, Gabrielle, Dubois, Frank, Carvalho, Diana M., Shih, Juliann, Zhang, Shu, Greenwald, Noah F., Zack, Travis, Shapira, Ofer, Pelton, Kristine, Hartley, Rachel, Bear, Heather, Georgis, Yohanna, Jarmale, Spandana, Melanson, Randy, Bonanno, Kevin, Schoolcraft, Kathleen, Miller, Peter G., Condurat, Alexandra L., Gonzalez, Elizabeth M., Qian, Kenin, Morin, Eric, Langhnoja, Jaldeep, Lupien, Leslie E., Rendo, Veronica, Digiacomo, Jeromy, Wang, Dayle, Zhou, Kevin, Kumbhani, Rushil, Guerra Garcia, Maria E., Sinai, Claire E., Becker, Sarah, Schneider, Rachel, Vogelzang, Jayne, Krug, Karsten, Goodale, Amy, Abid, Tanaz, Kalani, Zohra, Piccioni, Federica, Beroukhim, Rameen, Persky, Nicole S., Root, David E., Carcaboso, Angel M., Ebert, Benjamin L., Fuller, Christine, Babur, Ozgun, Kieran, Mark W., Jones, Chris, Keshishian, Hasmik, Ligon, Keith L., Carr, Steven A., Phoenix, Timothy N., Bandopadhayay, Pratiti
Publicado 2022