uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy

por Pavón, Miguel Angel, Arroyo-Solera, Irene, Céspedes, Maria Virtudes, Casanova, Isolda, León, Xavier, Mangues, Ramón
Publicado 2016

Efficient bioactive oligonucleotide‐protein conjugation for cell‐targeted cancer therapy

por Aviñó, Anna, Unzueta, Ugutz, Virtudes Céspedes, María, Casanova, Isolda, Vázquez, Esther, Villaverde, Antonio, Mangues, Ramon, Eritja, Ramon
Publicado 2019

Subcutaneous preconditioning increases invasion and metastatic dissemination in mouse colorectal cancer models

por Alamo, Patricia, Gallardo, Alberto, Pavón, Miguel A., Casanova, Isolda, Trias, Manuel, Mangues, Maria A., Vázquez, Esther, Villaverde, Antonio, Mangues, Ramon, Céspedes, Maria V.
Publicado 2014

Potent Anticancer Activity of CXCR4-Targeted Nanostructured Toxins in Aggressive Endometrial Cancer Models

por Medina-Gutiérrez, Esperanza, García-León, Annabel, Gallardo, Alberto, Álamo, Patricia, Alba-Castellón, Lorena, Unzueta, Ugutz, Villaverde, Antonio, Vázquez, Esther, Casanova, Isolda, Mangues, Ramon
Publicado 2022

Intracellular CXCR4(+) cell targeting with T22-empowered protein-only nanoparticles

por Unzueta, Ugutz, Céspedes, María Virtudes, Ferrer-Miralles, Neus, Casanova, Isolda, Cedano, Juan, Corchero, José Luis, Domingo-Espín, Joan, Villaverde, Antonio, Mangues, Ramón, Vázquez, Esther
Publicado 2012

Time-Prolonged Release of Tumor-Targeted Protein–MMAE Nanoconjugates from Implantable Hybrid Materials

por Serna, Naroa, Falgàs, Aïda, García-León, Annabel, Unzueta, Ugutz, Núñez, Yáiza, Sánchez-Chardi, Alejandro, Martínez-Torró, Carlos, Mangues, Ramón, Vazquez, Esther, Casanova, Isolda, Villaverde, Antonio
Publicado 2022

T22-PE24-H6 Nanotoxin Selectively Kills CXCR4-High Expressing AML Patient Cells In Vitro and Potently Blocks Dissemination In Vivo

por Núñez, Yáiza, Garcia-León, Annabel, Falgàs, Aïda, Serna, Naroa, Sánchez-García, Laura, Garrido, Ana, Sierra, Jorge, Gallardo, Alberto, Unzueta, Ugutz, Vázquez, Esther, Villaverde, Antonio, Mangues, Ramon, Casanova, Isolda
Publicado 2023

Artificial Inclusion Bodies for Clinical Development

por Sánchez, Julieta M., López‐Laguna, Hèctor, Álamo, Patricia, Serna, Naroa, Sánchez‐Chardi, Alejandro, Nolan, Verónica, Cano‐Garrido, Olivia, Casanova, Isolda, Unzueta, Ugutz, Vazquez, Esther, Mangues, Ramon, Villaverde, Antonio
Publicado 2019

Selective delivery of T22-PE24-H6 to CXCR4(+) diffuse large B-cell lymphoma cells leads to wide therapeutic index in a disseminated mouse model

por Falgàs, Aïda, Pallarès, Victor, Serna, Naroa, Sánchez-García, Laura, Sierra, Jorge, Gallardo, Alberto, Alba-Castellón, Lorena, Álamo, Patricia, Unzueta, Ugutz, Villaverde, Antonio, Vázquez, Esther, Mangues, Ramon, Casanova, Isolda
Publicado 2020

Specific Cytotoxic Effect of an Auristatin Nanoconjugate Towards CXCR4(+) Diffuse Large B-Cell Lymphoma Cells

por Falgàs, Aïda, Pallarès, Victor, Unzueta, Ugutz, Núñez, Yáiza, Sierra, Jorge, Gallardo, Alberto, Alba-Castellón, Lorena, Mangues, Maria Antonia, Álamo, Patricia, Villaverde, Antonio, Vázquez, Esther, Mangues, Ramon, Casanova, Isolda
Publicado 2021

A CXCR4-targeted nanocarrier achieves highly selective tumor uptake in diffuse large B-cell lymphoma mouse models

por Falgàs, Aïda, Pallarès, Victor, Unzueta, Ugutz, Céspedes, María Virtudes, Arroyo-Solera, Irene, Moreno, María José, Sierra, Jorge, Gallardo, Alberto, Mangues, María Antonia, Vázquez, Esther, Villaverde, Antonio, Mangues, Ramon, Casanova, Isolda
Publicado 2020

An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination

por Pallarès, Victor, Unzueta, Ugutz, Falgàs, Aïda, Sánchez-García, Laura, Serna, Naroa, Gallardo, Alberto, Morris, Gordon A., Alba-Castellón, Lorena, Álamo, Patricia, Sierra, Jorge, Villaverde, Antonio, Vázquez, Esther, Casanova, Isolda, Mangues, Ramon
Publicado 2020

GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases

por Sala, Rita, Rioja-Blanco, Elisa, Serna, Naroa, Sánchez-García, Laura, Álamo, Patricia, Alba-Castellón, Lorena, Casanova, Isolda, López-Pousa, Antonio, Unzueta, Ugutz, Céspedes, María Virtudes, Vázquez, Esther, Villaverde, Antonio, Mangues, Ramon
Publicado 2022

High RAB25 expression is associated with good clinical outcome in patients with locally advanced head and neck squamous cell carcinoma

por Téllez-Gabriel, Marta, Arroyo-Solera, Irene, León, Xavier, Gallardo, Alberto, López, Montserrat, Céspedes, Maria V, Casanova, Isolda, López-Pousa, Antonio, Quer, Miquel, Mangues, Maria A, Barnadas, Agustí, Mangues, Ramón, Pavón, Miguel A
Publicado 2013

Selective depletion of metastatic stem cells as therapy for human colorectal cancer

por Céspedes, María Virtudes, Unzueta, Ugutz, Aviñó, Anna, Gallardo, Alberto, Álamo, Patricia, Sala, Rita, Sánchez‐Chardi, Alejandro, Casanova, Isolda, Mangues, María Antònia, Lopez‐Pousa, Antonio, Eritja, Ramón, Villaverde, Antonio, Vázquez, Esther, Mangues, Ramón
Publicado 2018

Biparatopic Protein Nanoparticles for the Precision Therapy of CXCR4(+) Cancers

por Cano-Garrido, Olivia, Álamo, Patricia, Sánchez-García, Laura, Falgàs, Aïda, Sánchez-Chardi, Alejandro, Serna, Naroa, Parladé, Eloi, Unzueta, Ugutz, Roldán, Mònica, Voltà-Durán, Eric, Casanova, Isolda, Villaverde, Antonio, Mangues, Ramón, Vázquez, Esther
Publicado 2021

CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma

por Rioja-Blanco, Elisa, Arroyo-Solera, Irene, Álamo, Patricia, Casanova, Isolda, Gallardo, Alberto, Unzueta, Ugutz, Serna, Naroa, Sánchez-García, Laura, Quer, Miquel, Villaverde, Antonio, Vázquez, Esther, León, Xavier, Alba-Castellón, Lorena, Mangues, Ramon
Publicado 2022

A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model

por Rioja-Blanco, Elisa, Gallardo, Alberto, Arroyo-Solera, Irene, Álamo, Patricia, Casanova, Isolda, Unzueta, Ugutz, Serna, Naroa, Sánchez-García, Laura, Quer, Miquel, Villaverde, Antonio, Vázquez, Esther, León, Xavier, Alba-Castellón, Lorena, Mangues, Ramon
Publicado 2022

Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4(+) head and neck squamous cell carcinoma tumors

por Rioja-Blanco, Elisa, Arroyo-Solera, Irene, Álamo, Patricia, Casanova, Isolda, Gallardo, Alberto, Unzueta, Ugutz, Serna, Naroa, Sánchez-García, Laura, Quer, Miquel, Villaverde, Antonio, Vázquez, Esther, Mangues, Ramon, Alba-Castellón, Lorena, León, Xavier
Publicado 2022

Novel Endometrial Cancer Models Using Sensitive Metastasis Tracing for CXCR4-Targeted Therapy in Advanced Disease

por Medina-Gutiérrez, Esperanza, Céspedes, María Virtudes, Gallardo, Alberto, Rioja-Blanco, Elisa, Pavón, Miquel Àngel, Asensio-Puig, Laura, Farré, Lourdes, Alba-Castellón, Lorena, Unzueta, Ugutz, Villaverde, Antonio, Vázquez, Esther, Casanova, Isolda, Mangues, Ramon
Publicado 2022