The assessment of the potential hepatotoxicity of new drugs by in vitro metabolomics

por Quintás, Guillermo, Castell, José V., Moreno-Torres, Marta
Publicado 2023

The Potential Role of Metabolomics in Drug-Induced Liver Injury (DILI) Assessment

por Moreno-Torres, Marta, Quintás, Guillermo, Castell, José V.
Publicado 2022

A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury

por García- Cañaveras, Juan Carlos, Castell, José V., Donato, M. Teresa, Lahoz, Agustín
Publicado 2016

Modeling a Novel Variant of Glycogenosis IXa Using a Clonal Inducible Reprogramming System to Generate “Diseased” Hepatocytes for Accurate Diagnosis

por Garcia-Llorens, Guillem, Lopez-Navarro, Sergi, Jaijo, Teresa, Castell, Jose V., Bort, Roque
Publicado 2022

Direct conversion of human fibroblast to hepatocytes using a single inducible polycistronic vector

por Ballester, Maria, Bolonio, Miguel, Santamaria, Ramon, Castell, José V., Ribes-Koninckx, Carmen, Bort, Roque
Publicado 2019

A robust reprogramming strategy for generating hepatocyte-like cells usable in pharmaco-toxicological studies

por Garcia-Llorens, Guillem, Martínez-Sena, Teresa, Pareja, Eugenia, Tolosa, Laia, Castell, José V., Bort, Roque
Publicado 2023

Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved

por Martínez-Sena, Teresa, Moro, Erika, Moreno-Torres, Marta, Quintás, Guillermo, Hengstler, Jan, Castell, José V.
Publicado 2023

Metabolomic analysis to discriminate drug-induced liver injury (DILI) phenotypes

por Quintás, Guillermo, Martínez-Sena, Teresa, Conde, Isabel, Pareja Ibars, Eugenia, Kleinjans, Jos, Castell, José V.
Publicado 2021

Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury

por Tolosa, Laia, Jiménez, Nuria, Pérez, Gabriela, Castell, José V., Gómez-Lechón, M. José, Donato, M. Teresa
Publicado 2017

Quantitative Prediction of Steatosis in Patients with Non-Alcoholic Fatty Liver by Means of Hepatic MicroRNAs Present in Serum and Correlating with Hepatic Fat

por Quintás, Guillermo, Caiment, Florian, Rienda, Iván, Pérez-Rojas, Judith, Pareja, Eugenia, Castell, José V., Jover, Ramiro
Publicado 2022

Silencing of hepatic fate-conversion factors induce tumorigenesis in reprogrammed hepatic progenitor-like cells

por Serrano, Felipe, García-Bravo, Maria, Blazquez, Marina, Torres, Josema, Castell, Jose V., Segovia, Jose C., Bort, Roque
Publicado 2016

Monitoring of system conditioning after blank injections in untargeted UPLC-MS metabolomic analysis

por Martínez-Sena, Teresa, Luongo, Giovanna, Sanjuan-Herráez, Daniel, Castell, José V., Vento, Máximo, Quintás, Guillermo, Kuligowski, Julia
Publicado 2019

A Physiology-Based Model of Human Bile Acid Metabolism for Predicting Bile Acid Tissue Levels After Drug Administration in Healthy Subjects and BRIC Type 2 Patients

por Baier, Vanessa, Cordes, Henrik, Thiel, Christoph, Castell, José V., Neumann, Ulf P., Blank, Lars M., Kuepfer, Lars
Publicado 2019

New microRNA Biomarkers for Drug-Induced Steatosis and Their Potential to Predict the Contribution of Drugs to Non-alcoholic Fatty Liver Disease

por López-Riera, Mireia, Conde, Isabel, Tolosa, Laia, Zaragoza, Ángela, Castell, José V., Gómez-Lechón, María J., Jover, Ramiro
Publicado 2017

Derivation of healthy hepatocyte-like cells from a female patient with ornithine transcarbamylase deficiency through X-inactivation selection

por Santamaria, Ramon, Ballester, Maria, Garcia-Llorens, Guillem, Martinez, Francisco, Blazquez, Marina, Ribes-Koninckx, Carmen, Castell, Jose V., Wuestefeld, Torsten, Bort, Roque
Publicado 2022

Non-invasive prediction of NAFLD severity: a comprehensive, independent validation of previously postulated serum microRNA biomarkers

por López-Riera, Mireia, Conde, Isabel, Quintas, Guillermo, Pedrola, Laia, Zaragoza, Ángela, Perez-Rojas, Judith, Salcedo, Mario, Benlloch, Salvador, Castell, José V., Jover, Ramiro
Publicado 2018

Comparing Targeted vs. Untargeted MS(2) Data-Dependent Acquisition for Peak Annotation in LC–MS Metabolomics

por Ten-Doménech, Isabel, Martínez-Sena, Teresa, Moreno-Torres, Marta, Sanjuan-Herráez, Juan Daniel, Castell, José V., Parra-Llorca, Anna, Vento, Máximo, Quintás, Guillermo, Kuligowski, Julia
Publicado 2020

Gut Microbiota and Plasma Bile Acids Associated with Non-Alcoholic Fatty Liver Disease Resolution in Bariatric Surgery Patients

por Pérez-Rubio, Álvaro, Soluyanova, Polina, Moro, Erika, Quintás, Guillermo, Rienda, Iván, Periañez, María Dolores, Painel, Andrés, Vizuete, José, Pérez-Rojas, Judith, Castell, José V., Trullenque-Juan, Ramón, Pareja, Eugenia, Jover, Ramiro
Publicado 2023

The in vitro assessment of the toxicity of volatile, oxidisable, redox-cycling compounds: phenols as an example

por Tolosa, Laia, Martínez-Sena, Teresa, Schimming, Johannes P., Moro, Erika, Escher, Sylvia E., ter Braak, Bas, van der Water, Bob, Miranda, M. A., van Vugt-Lussenburg, Barbara M. A., Castell, José V.
Publicado 2021

Comparing in vitro human liver models to in vivo human liver using RNA-Seq

por Gupta, Rajinder, Schrooders, Yannick, Hauser, Duncan, van Herwijnen, Marcel, Albrecht, Wiebke, ter Braak, Bas, Brecklinghaus, Tim, Castell, Jose V., Elenschneider, Leroy, Escher, Sylvia, Guye, Patrick, Hengstler, Jan G., Ghallab, Ahmed, Hansen, Tanja, Leist, Marcel, Maclennan, Richard, Moritz, Wolfgang, Tolosa, Laia, Tricot, Tine, Verfaillie, Catherine, Walker, Paul, van de Water, Bob, Kleinjans, Jos, Caiment, Florian
Publicado 2020