The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity

por Xu, Catherine K., Castellana-Cruz, Marta, Chen, Serene W., Du, Zhen, Meisl, Georg, Levin, Aviad, Mannini, Benedetta, Itzhaki, Laura S., Knowles, Tuomas P. J., Dobson, Christopher M., Cremades, Nunilo, Kumita, Janet R.
Publicado 2022

Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores

por Sandler, Sarah E., Horne, Robert I., Rocchetti, Sara, Novak, Robert, Hsu, Nai-Shu, Castellana Cruz, Marta, Faidon Brotzakis, Z., Gregory, Rebecca C., Chia, Sean, Bernardes, Gonçalo J. L., Keyser, Ulrich F., Vendruscolo, Michele
Publicado 2023

N-Terminal Acetylation of α-Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates

por Bell, Rosie, Thrush, Rebecca J., Castellana-Cruz, Marta, Oeller, Marc, Staats, Roxine, Nene, Aishwarya, Flagmeier, Patrick, Xu, Catherine K., Satapathy, Sandeep, Galvagnion, Celine, Wilson, Mark R., Dobson, Christopher M., Kumita, Janet R., Vendruscolo, Michele
Publicado 2022

The binding of the small heat-shock protein αB-crystallin to fibrils of α-synuclein is driven by entropic forces

por Scheidt, Tom, Carozza, Jacqueline A., Kolbe, Carl C., Aprile, Francesco A., Tkachenko, Olga, Bellaiche, Mathias M. J., Meisl, Georg, Peter, Quentin A. E., Herling, Therese W., Ness, Samuel, Castellana-Cruz, Marta, Benesch, Justin L. P., Vendruscolo, Michele, Dobson, Christopher M., Arosio, Paolo, Knowles, Tuomas P. J.
Publicado 2021