Farnesol inhibits translation to limit growth and filamentation in C. albicans and S. cerevisiae

por Egbe, Nkechi E., Dornelles, Tawni O., Paget, Caroline M., Castelli, Lydia M., Ashe, Mark P.
Publicado 2017

Mechanisms of repeat-associated non-AUG translation in neurological microsatellite expansion disorders

por Castelli, Lydia M., Huang, Wan-Ping, Lin, Ya-Hui, Chang, Kung-Yao, Hautbergue, Guillaume M.
Publicado 2021

RNA Helicases in Microsatellite Repeat Expansion Disorders and Neurodegeneration

por Castelli, Lydia M., Benson, Bridget C., Huang, Wan-Ping, Lin, Ya-Hui, Hautbergue, Guillaume M.
Publicado 2022

Stress-dependent relocalization of translationally primed mRNPs to cytoplasmic granules that are kinetically and spatially distinct from P-bodies

por Hoyle, Nathaniel P., Castelli, Lydia M., Campbell, Susan G., Holmes, Leah E.A., Ashe, Mark P.
Publicado 2007

Overlapping regions of Caf20 mediate its interactions with the mRNA-5′cap-binding protein eIF4E and with ribosomes

por Nwokoye, Ebelechukwu C., AlNaseem, Eiman, Crawford, Robert A., Castelli, Lydia M., Jennings, Martin D., Kershaw, Christopher J., Pavitt, Graham D.
Publicado 2021

Granules Harboring Translationally Active mRNAs Provide a Platform for P-Body Formation following Stress

por Lui, Jennifer, Castelli, Lydia M., Pizzinga, Mariavittoria, Simpson, Clare E., Hoyle, Nathaniel P., Bailey, Kathryn L., Campbell, Susan G., Ashe, Mark P.
Publicado 2014

Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features

por Shaw, Matthew P., Higginbottom, Adrian, McGown, Alexander, Castelli, Lydia M., James, Evlyn, Hautbergue, Guillaume M., Shaw, Pamela J., Ramesh, Tennore M.
Publicado 2018

Puf3p induces translational repression of genes linked to oxidative stress

por Rowe, William, Kershaw, Christopher J., Castelli, Lydia M., Costello, Joseph L., Ashe, Mark P., Grant, Christopher M., Sims, Paul F. G., Pavitt, Graham D., Hubbard, Simon J.
Publicado 2014

Translation factor and RNA binding protein mRNA interactomes support broader RNA regulons for posttranscriptional control

por Kershaw, Christopher J., Nelson, Michael G., Castelli, Lydia M., Jennings, Martin D., Lui, Jennifer, Talavera, David, Grant, Chris M., Pavitt, Graham D., Hubbard, Simon J., Ashe, Mark P.
Publicado 2023

The Yeast La Related Protein Slf1p Is a Key Activator of Translation during the Oxidative Stress Response

por Kershaw, Christopher J., Costello, Joseph L., Castelli, Lydia M., Talavera, David, Rowe, William, Sims, Paul F. G., Ashe, Mark P., Hubbard, Simon J., Pavitt, Graham D., Grant, Chris M.
Publicado 2015

Integrated multi-omics analyses reveal the pleiotropic nature of the control of gene expression by Puf3p

por Kershaw, Christopher J., Costello, Joseph L., Talavera, David, Rowe, William, Castelli, Lydia M., Sims, Paul F. G., Grant, Christopher M., Ashe, Mark P., Hubbard, Simon J., Pavitt, Graham D.
Publicado 2015

Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses

por Costello, Joseph L., Kershaw, Christopher J., Castelli, Lydia M., Talavera, David, Rowe, William, Sims, Paul F. G., Ashe, Mark P., Grant, Christopher M., Hubbard, Simon J., Pavitt, Graham D.
Publicado 2017

Archetypal transcriptional blocks underpin yeast gene regulation in response to changes in growth conditions

por Talavera, David, Kershaw, Christopher J., Costello, Joseph L., Castelli, Lydia M., Rowe, William, Sims, Paul F. G., Ashe, Mark P., Grant, Chris M., Pavitt, Graham D., Hubbard, Simon J.
Publicado 2018

Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS

por Varcianna, André, Myszczynska, Monika A., Castelli, Lydia M., O'Neill, Brendan, Kim, Yeseul, Talbot, Jordan, Nyberg, Sophie, Nyamali, Immanuelle, Heath, Paul R., Stopford, Matthew J., Hautbergue, Guillaume M., Ferraiuolo, Laura
Publicado 2019

Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins

por Cridge, Andrew G., Castelli, Lydia M., Smirnova, Julia B., Selley, Julian N., Rowe, William, Hubbard, Simon J., McCarthy, John E.G., Ashe, Mark P., Grant, Christopher M., Pavitt, Graham D.
Publicado 2010

Global mRNA selection mechanisms for translation initiation

por Costello, Joseph, Castelli, Lydia M, Rowe, William, Kershaw, Christopher J, Talavera, David, Mohammad-Qureshi, Sarah S, Sims, Paul F G, Grant, Christopher M, Pavitt, Graham D, Hubbard, Simon J, Ashe, Mark P
Publicado 2015

The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation

por Castelli, Lydia M., Talavera, David, Kershaw, Christopher J., Mohammad-Qureshi, Sarah S., Costello, Joseph L., Rowe, William, Sims, Paul F. G., Grant, Christopher M., Hubbard, Simon J., Ashe, Mark P., Pavitt, Graham D.
Publicado 2015

Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up-regul...

por Castelli, Lydia M., Lui, Jennifer, Campbell, Susan G., Rowe, William, Zeef, Leo A. H., Holmes, Leah E. A., Hoyle, Nathaniel P., Bone, Jonathon, Selley, Julian N., Sims, Paul F. G., Ashe, Mark P.
Publicado 2011

Proteomic and cellular localisation studies suggest non‐tight junction cytoplasmic and nuclear roles for occludin in astrocytes

por Morgan, Sarah V., Garwood, Claire J., Jennings, Luke, Simpson, Julie E., Castelli, Lydia M., Heath, Paul R., Mihaylov, Simeon R., Vaquéz‐Villaseñor, Irina, Minshull, Thomas C., Ince, Paul G., Dickman, Mark J., Hautbergue, Guillaume M., Wharton, Stephen B.
Publicado 2018

Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease

por Gatto, Noemi, Dos Santos Souza, Cleide, Shaw, Allan C., Bell, Simon M., Myszczynska, Monika A., Powers, Samantha, Meyer, Kathrin, Castelli, Lydia M., Karyka, Evangelia, Mortiboys, Heather, Azzouz, Mimoun, Hautbergue, Guillaume M., Márkus, Nóra M., Shaw, Pamela J., Ferraiuolo, Laura
Publicado 2020