Biophysical and Pharmacological Characterization of Nav1.9 Voltage Dependent Sodium Channels Stably Expressed in HEK-293 Cells

por Lin, Zhixin, Santos, Sonia, Padilla, Karen, Printzenhoff, David, Castle, Neil A.
Publicado 2016

K(Ca)3.1 Channel-Blockade Attenuates Airway Pathophysiology in a Sheep Model of Chronic Asthma

por Van Der Velden, Joanne, Sum, Grace, Barker, Donna, Koumoundouros, Emmanuel, Barcham, Garry, Wulff, Heike, Castle, Neil, Bradding, Peter, Snibson, Kenneth
Publicado 2013

GI‐530159, a novel, selective, mechanosensitive two‐pore‐domain potassium (K(2P)) channel opener, reduces rat dorsal root ganglion neuron excitability

por Loucif, Alexandre J C, Saintot, Pierre‐Philippe, Liu, Jia, Antonio, Brett M, Zellmer, Shannon G, Yoger, Katrina, Veale, Emma L, Wilbrey, Anna, Omoto, Kiyoyuki, Cao, Lishuang, Gutteridge, Alex, Castle, Neil A, Stevens, Edward B, Mathie, Alistair
Publicado 2017

Small-molecule eRF3a degraders rescue CFTR nonsense mutations by promoting premature termination codon readthrough

por Lee, Rhianna E., Lewis, Catherine A., He, Lihua, Bulik-Sullivan, Emily C., Gallant, Samuel C., Mascenik, Teresa M., Dang, Hong, Cholon, Deborah M., Gentzsch, Martina, Morton, Lisa C., Minges, John T., Theile, Jonathan W., Castle, Neil A., Knowles, Michael R., Kimple, Adam J., Randell, Scott H.
Publicado 2022

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

por Alexandrou, Aristos J., Brown, Adam R., Chapman, Mark L., Estacion, Mark, Turner, Jamie, Mis, Malgorzata A., Wilbrey, Anna, Payne, Elizabeth C., Gutteridge, Alex, Cox, Peter J., Doyle, Rachel, Printzenhoff, David, Lin, Zhixin, Marron, Brian E., West, Christopher, Swain, Nigel A., Storer, R. Ian, Stupple, Paul A., Castle, Neil A., Hounshell, James A., Rivara, Mirko, Randall, Andrew, Dib-Hajj, Sulayman D., Krafte, Douglas, Waxman, Stephen G., Patel, Manoj K., Butt, Richard P., Stevens, Edward B.
Publicado 2016