N-(2-Hydroxyphenyl)-1-[3-(2-oxo-2,3-dihydro-1H- benzimidazol-1-yl)propyl]piperidine-4-Carboxamide (D2AAK4), a Multi-Target Ligand of Aminergic GPCRs, as a Potential Antipsychotic

por Kaczor, Agnieszka A., Targowska-Duda, Katarzyna M., Silva, Andrea G., Kondej, Magda, Biała, Grażyna, Castro, Marián
Publicado 2020

New Nitrogen Compounds Coupled to Phenolic Units with Antioxidant and Antifungal Activities: Synthesis and Structure–Activity Relationship

por Bettencourt, Ana, Castro, Marián, Silva, João, Fernandes, Francisco, Coutinho, Olga, Sousa, M. João, Proença, M. Fernanda, Areias, Filipe
Publicado 2018

Design and Synthesis of Arylpiperazine Serotonergic/Dopaminergic Ligands with Neuroprotective Properties

por Mastromarino, Margherita, Niso, Mauro, Abate, Carmen, Proschak, Ewgenij, Dubiel, Mariam, Stark, Holger, Castro, Marián, Lacivita, Enza, Leopoldo, Marcello
Publicado 2022

Synthesis, Structural and Thermal Studies of 3-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-5-ethoxy-1H-indole (D2AAK1_3) as Dopamine D(2) Receptor Ligand

por Kondej, Magda, Bartyzel, Agata, Pitucha, Monika, Wróbel, Tomasz M., Silva, Andrea G., Matosiuk, Dariusz, Castro, Marián, Kaczor, Agnieszka A.
Publicado 2018

Organ-Chips Enhance the Maturation of Human iPSC-Derived Dopamine Neurons

por Otero, Maria G., Bell, Shaughn, Laperle, Alexander H., Lawless, George, Myers, Zachary, Castro, Marian A., Villalba, Jaquelyn M., Svendsen, Clive N.
Publicado 2023

Allosteric modulation of dopamine D(2L) receptor in complex with G(i1) and G(i2) proteins: the effect of subtle structural and stereochemical ligand modifications

por Żuk, Justyna, Bartuzi, Damian, Silva, Andrea G., Pitucha, Monika, Koszła, Oliwia, Wróbel, Tomasz M., Matosiuk, Dariusz, Castro, Marián, Kaczor, Agnieszka A.
Publicado 2022

The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of h...

por Atanes, Patricio, Lacivita, Enza, Rodríguez, Javier, Brea, José, Burgueño, Javier, Vela, José Miguel, Cadavid, María Isabel, Loza, María Isabel, Leopoldo, Marcello, Castro, Marián
Publicado 2013

Distinct phosphorylation sites on the ghrelin receptor, GHSR1a, establish a code that determines the functions of ß-arrestins

por Bouzo-Lorenzo, Monica, Santo-Zas, Icía, Lodeiro, Maria, Nogueiras, Rubén, Casanueva, Felipe F., Castro, Marian, Pazos, Yolanda, Tobin, Andrew B, Butcher, Adrian J., Camiña, Jesús P.
Publicado 2016

Development and Characterization of Novel Selective, Non-Basic Dopamine D(2) Receptor Antagonists for the Treatment of Schizophrenia

por Stępnicki, Piotr, Wośko, Sylwia, Bartyzel, Agata, Zięba, Agata, Bartuzi, Damian, Szałaj, Klaudia, Wróbel, Tomasz M., Fornal, Emilia, Carlsson, Jens, Kędzierska, Ewa, Poleszak, Ewa, Castro, Marián, Kaczor, Agnieszka A.
Publicado 2023

A subchronic history of binge-drinking elicits mild, age- and sex-selective, affective, and cognitive anomalies in C57BL/6J mice

por Jimenez Chavez, C. Leonardo, Van Doren, Eliyana, Scheldrup, Gavin, Rivera, Emely, Torres-Gonzalez, Jose, Herbert, Jessica N., Denning, Christopher J. E., Khorsandi, Sarah, Garcia, Andrew, Castro, Marian, Szumlinski, Karen K.
Publicado 2023

Novel multi-target ligands of dopamine and serotonin receptors for the treatment of schizophrenia based on indazole and piperazine scaffolds–synthesis, biological activity, and str...

por Stępnicki, Piotr, Wronikowska-Denysiuk, Olga, Zięba, Agata, Targowska-Duda, Katarzyna M., Bartyzel, Agata, Wróbel, Martyna Z., Wróbel, Tomasz M., Szałaj, Klaudia, Chodkowski, Andrzej, Mirecka, Karolina, Budzyńska, Barbara, Fornal, Emilia, Turło, Jadwiga, Castro, Marián, Kaczor, Agnieszka A.
Publicado 2023

Development of Fluorescent Probes that Target Serotonin 5-HT(2B) Receptors

por Azuaje, Jhonny, López, Paula, Iglesias, Alba, de la Fuente, Rocío A., Pérez-Rubio, José M., García, Diego, Stępniewski, Tomasz Maciej, García-Mera, Xerardo, Brea, José M., Selent, Jana, Pérez, Dolores, Castro, Marián, Loza, María I., Sotelo, Eddy
Publicado 2017