Modulation of sirtuins during monolayer chondrocyte culture influences cartilage regeneration upon transfer to a 3D culture environment

por Heywood, Hannah K., Thorpe, Stephen D., Jeropoulos, Renos M., Caton, Paul W., Lee, David A.
Publicado 2022

Monomeric eNAMPT in the development of experimental diabetes in mice: a potential target for type 2 diabetes treatment

por Kieswich, Julius, Sayers, Sophie R., Silvestre, Marta F., Harwood, Steven M., Yaqoob, Muhammad M., Caton, Paul W.
Publicado 2016

A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain

por Kieswich, Julius E., Chen, Jianmin, Alliouachene, Samira, Caton, Paul W., McCafferty, Kieran, Thiemermann, Christoph, Yaqoob, Muhammad M.
Publicado 2018

Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators

por Tang, Siyuan, Garzon Sanz, Miguel, Smith, Oliver, Krämer, Andreas, Egbase, Daniel, Caton, Paul W., Knapp, Stefan, Butterworth, Sam
Publicado 2023

Carnosine scavenging of glucolipotoxic free radicals enhances insulin secretion and glucose uptake

por Cripps, Michael J., Hanna, Katie, Lavilla, Charlie, Sayers, Sophie R., Caton, Paul W., Sims, Craig, De Girolamo, Luigi, Sale, Craig, Turner, Mark D.
Publicado 2017

Sensory nerves mediate spontaneous behaviors in addition to inflammation in a murine model of psoriasis

por Kodji, Xenia, Arkless, Kate L., Kee, Zizheng, Cleary, Simon J., Aubdool, Aisah A., Evans, Elizabeth, Caton, Paul, Pitchford, Simon C., Brain, Susan D.
Publicado 2019

Psoriatic skin inflammation induces a pre-diabetic phenotype via the endocrine actions of skin secretome

por Evans, Elizabeth A., Sayers, Sophie R., Kodji, Xenia, Xia, Yue, Shaikh, Mahum, Rizvi, Alizah, Frame, James, Brain, Susan D., Philpott, Michael P., Hannen, Rosalind F., Caton, Paul W.
Publicado 2020

Glucolipotoxicity initiates pancreatic β-cell death through TNFR5/CD40-mediated STAT1 and NF-κB activation

por Bagnati, Marta, Ogunkolade, Babatunji W, Marshall, Catriona, Tucci, Carmen, Hanna, Katie, Jones, Tania A, Bugliani, Marco, Nedjai, Belinda, Caton, Paul W, Kieswich, Julius, Yaqoob, Muhammed M, Ball, Graham R, Marchetti, Piero, Hitman, Graham A, Turner, Mark D
Publicado 2016

Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes

por Sayers, Sophie R., Beavil, Rebecca L., Fine, Nicholas H. F., Huang, Guo C., Choudhary, Pratik, Pacholarz, Kamila J., Barran, Perdita E., Butterworth, Sam, Mills, Charlotte E., Cruickshank, J. Kennedy, Silvestre, Marta P., Poppitt, Sally D., McGill, Anne-Thea, Lavery, Gareth G., Hodson, David J., Caton, Paul W.
Publicado 2019