Pancreatic Islet Transcriptional Enhancers and Diabetes

por Cebola, Inês
Publicado 2019

Epigenetics of Hepatic Insulin Resistance

por Maude, Hannah, Sanchez-Cabanillas, Claudia, Cebola, Inês
Publicado 2021

Epigenetics override pro-inflammatory PTGS transcriptomic signature towards selective hyperactivation of PGE(2) in colorectal cancer

por Cebola, Inês, Custodio, Joaquin, Muñoz, Mar, Díez-Villanueva, Anna, Paré, Laia, Prieto, Patricia, Aussó, Susanna, Coll-Mulet, Llorenç, Boscá, Lisardo, Moreno, Victor, Peinado, Miguel A.
Publicado 2015

MiR-184 expression is regulated by AMPK in pancreatic islets

por Martinez-Sanchez, Aida, Nguyen-Tu, Marie-Sophie, Cebola, Ines, Yavari, Arash, Marchetti, Piero, Piemonti, Lorenzo, de Koning, Eelco, Shapiro, A. M. James, Johnson, Paul, Sakamoto, Kei, Smith, David M., Leclerc, Isabelle, Ashrafian, Houman, Ferrer, Jorge, Rutter, Guy A.
Publicado 2018

Dysregulated RNA polyadenylation contributes to metabolic impairment in non-alcoholic fatty liver disease

por Jobbins, Andrew M, Haberman, Nejc, Artigas, Natalia, Amourda, Christopher, Paterson, Helen A B, Yu, Sijia, Blackford, Samuel J I, Montoya, Alex, Dore, Marian, Wang, Yi-Fang, Sardini, Alessandro, Cebola, Inês, Zuber, Johannes, Rashid, Sheikh Tamir, Lenhard, Boris, Vernia, Santiago
Publicado 2022

Regulatory de novo mutations underlying intellectual disability

por De Vas, Matias G, Boulet, Fanny, Joshi, Shweta S, Garstang, Myles G, Khan, Tahir N, Atla, Goutham, Parry, David, Moore, David, Cebola, Inês, Zhang, Shuchen, Cui, Wei, Lampe, Anne K, Lam, Wayne W, Ferrer, Jorge, Pradeepa, Madapura M, Atanur, Santosh S
Publicado 2023

SOX17 enhancer variants disrupt transcription factor binding and enhancer inactivity drives pulmonary hypertension

por Walters, Rachel, Vasilaki, Eleni, Aman, Jurjan, Chen, Chien-Nien, Wu, Yukyee, Liang, Olin D, Ashek, Ali, Dubois, Olivier, Zhao, Lin, Sabrin, Farah, Cebola, Inês, Ferrer, Jorge, Morrell, Nicholas W, Klinger, James R, Wilkins, Martin R, Zhao, Lan, Rhodes, Christopher J
Publicado 2023

Dax1 modulates ERα-dependent hypothalamic estrogen sensing in female mice

por Ramos-Pittol, Jose M., Fernandes-Freitas, Isabel, Milona, Alexandra, Manchishi, Stephen M., Rainbow, Kara, Lam, Brian Y. H., Tadross, John A., Beucher, Anthony, Colledge, William H., Cebola, Inês, Murphy, Kevin G., Miguel-Aliaga, Irene, Yeo, Giles S. H., Dhillo, Waljit S., Owen, Bryn M.
Publicado 2023

Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion

por Hu, Ming, Cebola, Inês, Carrat, Gaelle, Jiang, Shuying, Nawaz, Sameena, Khamis, Amna, Canouil, Mickaël, Froguel, Philippe, Schulte, Anke, Solimena, Michele, Ibberson, Mark, Marchetti, Piero, Cardenas-Diaz, Fabian L., Gadue, Paul J., Hastoy, Benoit, Alemeida-Souza, Leonardo, McMahon, Harvey, Rutter, Guy A.
Publicado 2021

Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion

por Hu, Ming, Cebola, Inês, Carrat, Gaelle, Jiang, Shuying, Nawaz, Sameena, Khamis, Amna, Canouil, Mickaël, Froguel, Philippe, Schulte, Anke, Solimena, Michele, Ibberson, Mark, Marchetti, Piero, Cardenas-Diaz, Fabian L., Gadue, Paul J., Hastoy, Benoit, Almeida-Souza, Leonardo, McMahon, Harvey, Rutter, Guy A.
Publicado 2021

Rare variant association analysis in 51,256 type 2 diabetes cases and 370,487 controls informs the spectrum of pathogenicity of monogenic diabetes genes

por Schroeder, Philip, Mandla, Ravi, Huerta-Chagoya, Alicia, Alkanak, Ahmed, Nagy, Dorka, Szczerbinski, Lukasz, Madsen, Jesper G.S., Cole, Joanne B., Porneala, Bianca, Westerman, Kenneth, Li, Josephine H., Pollin, Toni I., Florez, Jose C., Gloyn, Anna L., Cebola, Inês, Manning, Alisa, Leong, Aaron, Udler, Miriam, Mercader, Josep M.
Publicado 2023

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors

por Cebola, Inês, Rodríguez-Seguí, Santiago A., Cho, Candy H.-H., Bessa, José, Rovira, Meritxell, Luengo, Mario, Chhatriwala, Mariya, Berry, Andrew, Ponsa-Cobas, Joan, Maestro, Miguel Angel, Jennings, Rachel E., Pasquali, Lorenzo, Morán, Ignasi, Castro, Natalia, Hanley, Neil A., Gomez-Skarmeta, Jose Luis, Vallier, Ludovic, Ferrer, Jorge
Publicado 2015

Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis

por Weedon, Michael N., Cebola, Ines, Patch, Ann-Marie, Flanagan, Sarah E., De Franco, Elisa, Caswell, Richard, Rodríguez-Seguí, Santiago A., Shaw-Smith, Charles, Cho, Candy H-H., Allen, Hana Lango, Houghton, Jayne AL., Roth, Christian L., Chen, Rongrong, Hussain, Khalid, Marsh, Phil, Vallier, Ludovic, Murray, Anna, Ellard, Sian, Ferrer, Jorge, Hattersley, Andrew T.
Publicado 2013

GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements

por Dixon, Peter H., Levine, Adam P., Cebola, Inês, Chan, Melanie M. Y., Amin, Aliya S., Aich, Anshul, Mozere, Monika, Maude, Hannah, Mitchell, Alice L., Zhang, Jun, Chambers, Jenny, Syngelaki, Argyro, Donnelly, Jennifer, Cooley, Sharon, Geary, Michael, Nicolaides, Kypros, Thorsell, Malin, Hague, William M., Estiu, Maria Cecilia, Marschall, Hanns-Ulrich, Gale, Daniel P., Williamson, Catherine
Publicado 2022

Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice

por Paterson, Helen A. B., Yu, Sijia, Artigas, Natalia, Prado, Miguel A., Haberman, Nejc, Wang, Yi-Fang, Jobbins, Andrew M., Pahita, Elena, Mokochinski, Joao, Hall, Zoe, Guerin, Maryse, Paulo, Joao A., Ng, Soon Seng, Villarroya, Francesc, Rashid, Sheikh Tamir, Le Goff, Wilfried, Lenhard, Boris, Cebola, Inês, Finley, Daniel, Gygi, Steven P., Sibley, Christopher R., Vernia, Santiago
Publicado 2022

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk–associated variants

por Pasquali, Lorenzo, Gaulton, Kyle J., Rodríguez-Seguí, Santiago A., Mularoni, Loris, Miguel-Escalada, Irene, Akerman, İldem, Tena, Juan J., Morán, Ignasi, Gómez-Marín, Carlos, van de Bunt, Martijn, Ponsa-Cobas, Joan, Castro, Natalia, Nammo, Takao, Cebola, Inês, García-Hurtado, Javier, Maestro, Miguel Angel, Pattou, François, Piemonti, Lorenzo, Berney, Thierry, Gloyn, Anna L., Ravassard, Philippe, Skarmeta, José Luis Gómez, Müller, Ferenc, McCarthy, Mark I., Ferrer, Jorge
Publicado 2014

Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes

por McAllan, Liam, Baranasic, Damir, Villicaña, Sergio, Brown, Scarlett, Zhang, Weihua, Lehne, Benjamin, Adamo, Marco, Jenkinson, Andrew, Elkalaawy, Mohamed, Mohammadi, Borzoueh, Hashemi, Majid, Fernandes, Nadia, Lambie, Nathalie, Williams, Richard, Christiansen, Colette, Yang, Youwen, Zudina, Liudmila, Lagou, Vasiliki, Tan, Sili, Castillo-Fernandez, Juan, King, James W. D., Soong, Richie, Elliott, Paul, Scott, James, Prokopenko, Inga, Cebola, Inês, Loh, Marie, Lenhard, Boris, Batterham, Rachel L., Bell, Jordana T., Chambers, John C., Kooner, Jaspal S., Scott, William R.
Publicado 2023

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis

por Rhodes, Christopher J, Batai, Ken, Bleda, Marta, Haimel, Matthias, Southgate, Laura, Germain, Marine, Pauciulo, Michael W, Hadinnapola, Charaka, Aman, Jurjan, Girerd, Barbara, Arora, Amit, Knight, Jo, Hanscombe, Ken B, Karnes, Jason H, Kaakinen, Marika, Gall, Henning, Ulrich, Anna, Harbaum, Lars, Cebola, Inês, Ferrer, Jorge, Lutz, Katie, Swietlik, Emilia M, Ahmad, Ferhaan, Amouyel, Philippe, Archer, Stephen L, Argula, Rahul, Austin, Eric D, Badesch, David, Bakshi, Sahil, Barnett, Christopher, Benza, Raymond, Bhatt, Nitin, Bogaard, Harm J, Burger, Charles D, Chakinala, Murali, Church, Colin, Coghlan, John G, Condliffe, Robin, Corris, Paul A, Danesino, Cesare, Debette, Stéphanie, Elliott, C Gregory, Elwing, Jean, Eyries, Melanie, Fortin, Terry, Franke, Andre, Frantz, Robert P, Frost, Adaani, Garcia, Joe G N, Ghio, Stefano, Ghofrani, Hossein-Ardeschir, Gibbs, J Simon R, Harley, John, He, Hua, Hill, Nicholas S, Hirsch, Russel, Houweling, Arjan C, Howard, Luke S, Ivy, Dunbar, Kiely, David G, Klinger, James, Kovacs, Gabor, Lahm, Tim, Laudes, Matthias, Machado, Rajiv D, MacKenzie Ross, Robert V, Marsolo, Keith, Martin, Lisa J, Moledina, Shahin, Montani, David, Nathan, Steven D, Newnham, Michael, Olschewski, Andrea, Olschewski, Horst, Oudiz, Ronald J, Ouwehand, Willem H, Peacock, Andrew J, Pepke-Zaba, Joanna, Rehman, Zia, Robbins, Ivan, Roden, Dan M, Rosenzweig, Erika B, Saydain, Ghulam, Scelsi, Laura, Schilz, Robert, Seeger, Werner, Shaffer, Christian M, Simms, Robert W, Simon, Marc, Sitbon, Olivier, Suntharalingam, Jay, Tang, Haiyang, Tchourbanov, Alexander Y, Thenappan, Thenappan, Torres, Fernando, Toshner, Mark R, Treacy, Carmen M, Vonk Noordegraaf, Anton, Waisfisz, Quinten, Walsworth, Anna K, Walter, Robert E, Wharton, John, White, R James, Wilt, Jeffrey, Wort, Stephen J, Yung, Delphine, Lawrie, Allan, Humbert, Marc, Soubrier, Florent, Trégouët, David-Alexandre, Prokopenko, Inga, Kittles, Richard, Gräf, Stefan, Nichols, William C, Trembath, Richard C, Desai, Ankit A, Morrell, Nicholas W, Wilkins, Martin R
Publicado 2019